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Articles, Cellular/Molecular

Global Ca2+ Signaling Drives Ribbon-Independent Synaptic Transmission at Rod Bipolar Cell Synapses

Bhupesh Mehta, Jiang-Bin Ke, Lei Zhang, Alexander D. Baden, Alexander L. Markowitz, Subhashree Nayak, Kevin L. Briggman, David Zenisek and Joshua H. Singer
Journal of Neuroscience 30 April 2014, 34 (18) 6233-6244; https://doi.org/10.1523/JNEUROSCI.5324-13.2014
Bhupesh Mehta
1Departments of Cellular and Molecular Physiology and Ophthalmology and Visual Science, Yale University, New Haven, Connecticut 06520,
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Jiang-Bin Ke
2Department of Biology, University of Maryland, College Park, Maryland 20742, and
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Lei Zhang
2Department of Biology, University of Maryland, College Park, Maryland 20742, and
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Alexander D. Baden
2Department of Biology, University of Maryland, College Park, Maryland 20742, and
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Alexander L. Markowitz
2Department of Biology, University of Maryland, College Park, Maryland 20742, and
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Subhashree Nayak
2Department of Biology, University of Maryland, College Park, Maryland 20742, and
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Kevin L. Briggman
3Circuit Dynamics and Connectivity Unit, National Institutes of Health (NIH)/National Institute of Neurological Disorders and Stroke (NINDS), Bethesda, Maryland 20892
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David Zenisek
1Departments of Cellular and Molecular Physiology and Ophthalmology and Visual Science, Yale University, New Haven, Connecticut 06520,
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Joshua H. Singer
2Department of Biology, University of Maryland, College Park, Maryland 20742, and
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Abstract

Ribbon-type presynaptic active zones are a hallmark of excitatory retinal synapses, and the ribbon organelle is thought to serve as the organizing point of the presynaptic active zone. Imaging of exocytosis from isolated retinal neurons, however, has revealed ectopic release (i.e., release away from ribbons) in significant quantities. Here, we demonstrate in an in vitro mouse retinal slice preparation that ribbon-independent release from rod bipolar cells activates postsynaptic AMPARs on AII amacrine cells. This form of release appears to draw on a unique, ribbon-independent, vesicle pool. Experimental, anatomical, and computational analyses indicate that it is elicited by a significant, global elevation of intraterminal [Ca2+] arising following local buffer saturation. Our observations support the conclusion that ribbon-independent release provides a read-out of the average behavior of all of the active zones in a rod bipolar cell's terminal.

  • exocytosis
  • retina
  • ribbon
  • vesicle
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The Journal of Neuroscience: 34 (18)
Journal of Neuroscience
Vol. 34, Issue 18
30 Apr 2014
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Global Ca2+ Signaling Drives Ribbon-Independent Synaptic Transmission at Rod Bipolar Cell Synapses
Bhupesh Mehta, Jiang-Bin Ke, Lei Zhang, Alexander D. Baden, Alexander L. Markowitz, Subhashree Nayak, Kevin L. Briggman, David Zenisek, Joshua H. Singer
Journal of Neuroscience 30 April 2014, 34 (18) 6233-6244; DOI: 10.1523/JNEUROSCI.5324-13.2014

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Global Ca2+ Signaling Drives Ribbon-Independent Synaptic Transmission at Rod Bipolar Cell Synapses
Bhupesh Mehta, Jiang-Bin Ke, Lei Zhang, Alexander D. Baden, Alexander L. Markowitz, Subhashree Nayak, Kevin L. Briggman, David Zenisek, Joshua H. Singer
Journal of Neuroscience 30 April 2014, 34 (18) 6233-6244; DOI: 10.1523/JNEUROSCI.5324-13.2014
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Keywords

  • exocytosis
  • retina
  • ribbon
  • vesicle

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