Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
    • Special Collections
  • EDITORIAL BOARD
    • Editorial Board
    • ECR Advisory Board
    • Journal Staff
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
    • Accessibility
  • SUBSCRIBE

User menu

  • Log out
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Neuroscience
  • Log out
  • Log in
  • My Cart
Journal of Neuroscience

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
    • Special Collections
  • EDITORIAL BOARD
    • Editorial Board
    • ECR Advisory Board
    • Journal Staff
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
    • Accessibility
  • SUBSCRIBE
PreviousNext
Brief Communications

Differential Effects of Presynaptic versus Postsynaptic Adenosine A2A Receptor Blockade on Δ9-Tetrahydrocannabinol (THC) Self-Administration in Squirrel Monkeys

Zuzana Justinová, Godfrey H. Redhi, Steven R. Goldberg and Sergi Ferré
Journal of Neuroscience 7 May 2014, 34 (19) 6480-6484; https://doi.org/10.1523/JNEUROSCI.5073-13.2014
Zuzana Justinová
1Preclinical Pharmacology Section of Behavioral Neuroscience Research Branch and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Godfrey H. Redhi
1Preclinical Pharmacology Section of Behavioral Neuroscience Research Branch and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Steven R. Goldberg
1Preclinical Pharmacology Section of Behavioral Neuroscience Research Branch and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sergi Ferré
2Integrative Neurobiology Section of Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Figures & Data

Figures

  • Figure 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 1.

    Effects of pretreatment with A2A receptor antagonists on responding maintained by food under an FR10 schedule in squirrel monkeys. A, B, Effects of pretreatment with SCH-442416 (0.3–3 mg/kg, i.m.), KW-6002 (0.1–1 mg/kg, i.m.), or vehicles on food-maintained responding are shown for the number of food pellets self-administered over a session (A) and overall rates of responding (B). Each bar represents the mean ± SEM from three monkeys over three sessions under each condition. *p < 0.05, **p < 0.01, post hoc comparisons versus vehicle pretreatment (0 mg/kg), Bonferroni's test.

  • Figure 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 2.

    Effects of A2A receptor antagonists on self-administration of a THC dose (4 μg/kg per injection) that maintains maximum rates of responding under an FR10 schedule in squirrel monkeys. A, B, SCH-442416 (0.03–1 mg/kg, i.m.) significantly decreased the number of THC injections self-administered during 1 h sessions (A) and decreased overall response rates (B) (n = 5). C, D, KW-6002 (0.3 and 1 mg/kg, i.m.) significantly decreased the number of THC injections self-administered during the sessions (C) and decreased overall response rates (D) (n = 4). The number of THC injections per session (A, C) and overall response rates in the presence of the green light signaling THC availability (B, D) are shown over consecutive sessions. Each data point represents the mean ± SEM. *p < 0.05, **p < 0.01, planned comparisons with Holm correction versus the mean of the three sessions with vehicle pretreatment (sessions 1–3).

  • Figure 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 3.

    Effects of A2A receptor antagonists on self-administration of different doses of THC under an FR10 schedule in squirrel monkeys. A, B, Dose–response curves for THC self-administration after intramuscular pretreatment with SCH-442416 (1 mg/kg) or vehicle. C, D, Dose–response curves for THC self-administration after intramuscular pretreatment with KW-6002 (0.3 mg/kg) or vehicle. The number of THC injections per session (A, C) and overall response rates in the presence of the green light signaling THC availability (B, D) are shown as a function of THC dose. Each data point represents the mean ± SEM of the last three sessions under each THC condition and under vehicle conditions (n = 4). *p < 0.05, **p < 0.01, post hoc comparisons of the effects of pretreatment with vehicle versus SCH-442416 or KW-6002 within each THC dose, Tukey's test. V, Vehicle.

Back to top

In this issue

The Journal of Neuroscience: 34 (19)
Journal of Neuroscience
Vol. 34, Issue 19
7 May 2014
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Advertising (PDF)
  • Ed Board (PDF)
Email

Thank you for sharing this Journal of Neuroscience article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Differential Effects of Presynaptic versus Postsynaptic Adenosine A2A Receptor Blockade on Δ9-Tetrahydrocannabinol (THC) Self-Administration in Squirrel Monkeys
(Your Name) has forwarded a page to you from Journal of Neuroscience
(Your Name) thought you would be interested in this article in Journal of Neuroscience.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Differential Effects of Presynaptic versus Postsynaptic Adenosine A2A Receptor Blockade on Δ9-Tetrahydrocannabinol (THC) Self-Administration in Squirrel Monkeys
Zuzana Justinová, Godfrey H. Redhi, Steven R. Goldberg, Sergi Ferré
Journal of Neuroscience 7 May 2014, 34 (19) 6480-6484; DOI: 10.1523/JNEUROSCI.5073-13.2014

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Request Permissions
Share
Differential Effects of Presynaptic versus Postsynaptic Adenosine A2A Receptor Blockade on Δ9-Tetrahydrocannabinol (THC) Self-Administration in Squirrel Monkeys
Zuzana Justinová, Godfrey H. Redhi, Steven R. Goldberg, Sergi Ferré
Journal of Neuroscience 7 May 2014, 34 (19) 6480-6484; DOI: 10.1523/JNEUROSCI.5073-13.2014
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • adenosine A2A receptor
  • cannabinoids
  • drug abuse
  • monkey
  • self-administration
  • THC

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

  • Heteromodal Cortical Areas Encode Sensory-Motor Features of Word Meaning
  • Pharmacologically Counteracting a Phenotypic Difference in Cerebellar GABAA Receptor Response to Alcohol Prevents Excessive Alcohol Consumption in a High Alcohol-Consuming Rodent Genotype
  • Neuromuscular NMDA Receptors Modulate Developmental Synapse Elimination
Show more Brief Communications
  • Home
  • Alerts
  • Follow SFN on BlueSky
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Issue Archive
  • Collections

Information

  • For Authors
  • For Advertisers
  • For the Media
  • For Subscribers

About

  • About the Journal
  • Editorial Board
  • Privacy Notice
  • Contact
  • Accessibility
(JNeurosci logo)
(SfN logo)

Copyright © 2025 by the Society for Neuroscience.
JNeurosci Online ISSN: 1529-2401

The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.