Article Figures & Data
Figures
- Figure 1.
Effects of pretreatment with A2A receptor antagonists on responding maintained by food under an FR10 schedule in squirrel monkeys. A, B, Effects of pretreatment with SCH-442416 (0.3–3 mg/kg, i.m.), KW-6002 (0.1–1 mg/kg, i.m.), or vehicles on food-maintained responding are shown for the number of food pellets self-administered over a session (A) and overall rates of responding (B). Each bar represents the mean ± SEM from three monkeys over three sessions under each condition. *p < 0.05, **p < 0.01, post hoc comparisons versus vehicle pretreatment (0 mg/kg), Bonferroni's test.
- Figure 2.
Effects of A2A receptor antagonists on self-administration of a THC dose (4 μg/kg per injection) that maintains maximum rates of responding under an FR10 schedule in squirrel monkeys. A, B, SCH-442416 (0.03–1 mg/kg, i.m.) significantly decreased the number of THC injections self-administered during 1 h sessions (A) and decreased overall response rates (B) (n = 5). C, D, KW-6002 (0.3 and 1 mg/kg, i.m.) significantly decreased the number of THC injections self-administered during the sessions (C) and decreased overall response rates (D) (n = 4). The number of THC injections per session (A, C) and overall response rates in the presence of the green light signaling THC availability (B, D) are shown over consecutive sessions. Each data point represents the mean ± SEM. *p < 0.05, **p < 0.01, planned comparisons with Holm correction versus the mean of the three sessions with vehicle pretreatment (sessions 1–3).
- Figure 3.
Effects of A2A receptor antagonists on self-administration of different doses of THC under an FR10 schedule in squirrel monkeys. A, B, Dose–response curves for THC self-administration after intramuscular pretreatment with SCH-442416 (1 mg/kg) or vehicle. C, D, Dose–response curves for THC self-administration after intramuscular pretreatment with KW-6002 (0.3 mg/kg) or vehicle. The number of THC injections per session (A, C) and overall response rates in the presence of the green light signaling THC availability (B, D) are shown as a function of THC dose. Each data point represents the mean ± SEM of the last three sessions under each THC condition and under vehicle conditions (n = 4). *p < 0.05, **p < 0.01, post hoc comparisons of the effects of pretreatment with vehicle versus SCH-442416 or KW-6002 within each THC dose, Tukey's test. V, Vehicle.
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