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Articles, Neurobiology of Disease

Conditional Ablation of Orexin/Hypocretin Neurons: A New Mouse Model for the Study of Narcolepsy and Orexin System Function

Sawako Tabuchi, Tomomi Tsunematsu, Sarah W. Black, Makoto Tominaga, Megumi Maruyama, Kazuyo Takagi, Yasuhiko Minokoshi, Takeshi Sakurai, Thomas S. Kilduff and Akihiro Yamanaka
Journal of Neuroscience 7 May 2014, 34 (19) 6495-6509; DOI: https://doi.org/10.1523/JNEUROSCI.0073-14.2014
Sawako Tabuchi
1Research Institute of Environmental Medicine, Nagoya University, Nagoya, 464-8601, Japan,
2Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki 444-8585, Japan,
3Japan Society for the Promotion of Science, Tokyo 102-8472, Japan,
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Tomomi Tsunematsu
1Research Institute of Environmental Medicine, Nagoya University, Nagoya, 464-8601, Japan,
3Japan Society for the Promotion of Science, Tokyo 102-8472, Japan,
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Sarah W. Black
4Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California 94025,
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Makoto Tominaga
2Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki 444-8585, Japan,
5Division of Cell Signaling, National Institute for Physiological Sciences, National Institute of Natural Sciences, Okazaki 444-8787, Japan,
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Megumi Maruyama
1Research Institute of Environmental Medicine, Nagoya University, Nagoya, 464-8601, Japan,
6Center for Multidisciplinary Brain Research, National Institute for Physiological Sciences, National Institute of Natural Sciences, Okazaki 444-8585, Japan,
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Kazuyo Takagi
2Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki 444-8585, Japan,
7Division of Endocrinology and Metabolism, National Institute for Physiological Sciences, National Institute of Natural Sciences, Okazaki 444-8585, Japan, and
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Yasuhiko Minokoshi
2Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki 444-8585, Japan,
7Division of Endocrinology and Metabolism, National Institute for Physiological Sciences, National Institute of Natural Sciences, Okazaki 444-8585, Japan, and
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Takeshi Sakurai
8Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan
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Thomas S. Kilduff
4Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California 94025,
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Akihiro Yamanaka
1Research Institute of Environmental Medicine, Nagoya University, Nagoya, 464-8601, Japan,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0073-14.2014
PubMed 
24806676
Published By 
Society for Neuroscience
History 
  • Received January 7, 2014
  • Revision received March 25, 2014
  • Accepted March 28, 2014
  • First published May 7, 2014.
  • Version of record published May 7, 2014.
Copyright & Usage 
Copyright © 2014 the authors 0270-6474/14/346495-15$15.00/0 This article is freely available online through the J Neurosci Author Open Choice option.

Author Information

  1. Sawako Tabuchi1,2,3,
  2. Tomomi Tsunematsu1,3,
  3. Sarah W. Black4,
  4. Makoto Tominaga2,5,
  5. Megumi Maruyama1,6,
  6. Kazuyo Takagi2,7,
  7. Yasuhiko Minokoshi2,7,
  8. Takeshi Sakurai8,
  9. Thomas S. Kilduff4, and
  10. Akihiro Yamanaka1
  1. 1Research Institute of Environmental Medicine, Nagoya University, Nagoya, 464-8601, Japan,
  2. 2Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki 444-8585, Japan,
  3. 3Japan Society for the Promotion of Science, Tokyo 102-8472, Japan,
  4. 4Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California 94025,
  5. 5Division of Cell Signaling, National Institute for Physiological Sciences, National Institute of Natural Sciences, Okazaki 444-8787, Japan,
  6. 6Center for Multidisciplinary Brain Research, National Institute for Physiological Sciences, National Institute of Natural Sciences, Okazaki 444-8585, Japan,
  7. 7Division of Endocrinology and Metabolism, National Institute for Physiological Sciences, National Institute of Natural Sciences, Okazaki 444-8585, Japan, and
  8. 8Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan
View Full Text

Author contributions

  1. Author contributions: A.Y. designed research; S.T., T.T., M.M., and K.T. performed research; Y.M. and T.S. contributed unpublished reagents/analytic tools; S.T., T.T., S.W.B., and M.T. analyzed data; S.T., T.S.K., and A.Y. wrote the paper.

Disclosures

    • Received January 7, 2014.
    • Revision received March 25, 2014.
    • Accepted March 28, 2014.
  • This work was supported by Grant-in-Aid for Scientific Research on Innovative Areas “Mesoscopic Neurocircuitry” (23115103), Grant-in-Aid for Scientific Research (B) (23300142) to A.Y., the JST PRESTO program, Japan Society for Promotion of Science research fellowship for young researcher to S.T. and postdoctoral fellowship to T.T., and National Institutes of Health Grants R01 NS057464 and NS077408 to T.S.K. We thank Claire Saito and Keiko Nishimura for technical assistance.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to either of the following: Dr. Akihiro Yamanaka, Research Institute of Environmental Medicine, Nagoya University, Nagoya, 464-8601, Japan, yamank{at}riem.nagoya-u.ac.jp; or Thomas S. Kilduff, Center for Neuroscience, Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, thomas.kilduff{at}sri.com

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AbstractFullPdf
May 20142462312442
Jun 2014302113128
Jul 201424314455
Aug 20141112737
Sep 20141497575
Oct 20141375669
Nov 20141536458
Dec 2014725371
Total 20143629844935
Jan 2015916661
Feb 2015858062
Mar 20151057642
Apr 2015625837
May 2015655734
Jun 2015324522
Jul 2015554835
Aug 2015533431
Sep 2015644229
Oct 2015654438
Nov 2015583127
Dec 2015503926
Total 2015785620444
Jan 2016492715
Feb 2016484328
Mar 2016865255
Apr 2016521846
May 2016532930
Jun 2016483924
Jul 2016493713
Aug 2016452617
Sep 2016492330
Oct 2016354334
Nov 2016295147
Dec 2016283627
Total 2016571424366
Jan 2017315228
Feb 2017314719
Mar 2017425812
Apr 2017205425
May 2017195320
Jun 2017196325
Jul 2017134119
Aug 201715266
Sep 2017334521
Oct 2017237428
Nov 2017266723
Dec 2017245215
Total 2017296632241
Jan 2018314830
Feb 2018186220
Mar 2018498418
Apr 2018295927
May 20182015430
Jun 20181310128
Jul 2018115212
Aug 2018105830
Sep 2018124814
Oct 2018225537
Nov 2018193817
Dec 2018184025
Total 2018252799288
Jan 2019103214
Feb 2019184823
Mar 2019134826
Apr 2019126634
May 20191321129
Jun 2019122016
Jul 201963624
Aug 201954223
Sep 20191733622
Oct 2019437634
Nov 2019275837
Dec 2019163910
Total 2019348712292
Jan 2020205317
Feb 2020243016
Mar 2020134722
Apr 2020165630
May 2020196232
Jun 202024621
Jul 2020103518
Aug 2020113518
Sep 2020156943
Oct 2020135017
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Dec 2020168222
Total 2020172618270
Jan 202195127
Feb 2021277134
Mar 2021226540
Apr 2021195126
May 2021106037
Jun 2021114914
Jul 2021223731
Aug 2021194024
Sep 2021237839
Oct 2021197150
Nov 2021238255
Dec 2021194528
Total 2021223700405
Jan 202295310
Feb 2022184826
Mar 2022185429
Apr 2022234220
May 2022106333
Jun 202255322
Total 202283313140
Total635956623381
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The Journal of Neuroscience: 34 (19)
Journal of Neuroscience
Vol. 34, Issue 19
7 May 2014
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Conditional Ablation of Orexin/Hypocretin Neurons: A New Mouse Model for the Study of Narcolepsy and Orexin System Function
Sawako Tabuchi, Tomomi Tsunematsu, Sarah W. Black, Makoto Tominaga, Megumi Maruyama, Kazuyo Takagi, Yasuhiko Minokoshi, Takeshi Sakurai, Thomas S. Kilduff, Akihiro Yamanaka
Journal of Neuroscience 7 May 2014, 34 (19) 6495-6509; DOI: 10.1523/JNEUROSCI.0073-14.2014

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Conditional Ablation of Orexin/Hypocretin Neurons: A New Mouse Model for the Study of Narcolepsy and Orexin System Function
Sawako Tabuchi, Tomomi Tsunematsu, Sarah W. Black, Makoto Tominaga, Megumi Maruyama, Kazuyo Takagi, Yasuhiko Minokoshi, Takeshi Sakurai, Thomas S. Kilduff, Akihiro Yamanaka
Journal of Neuroscience 7 May 2014, 34 (19) 6495-6509; DOI: 10.1523/JNEUROSCI.0073-14.2014
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Keywords

  • diphtheria toxin A fragment
  • hypocretin
  • model mice
  • narcolepsy
  • orexin
  • transgenic

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