Article Information
- Received January 8, 2014
- Revision received March 11, 2014
- Accepted April 8, 2014
- First published May 14, 2014.
- Version of record published May 14, 2014.
Author Information
- Yajing Peng1,
- Mi Li1,
- Ben D. Clarkson2,*,
- Mariana Pehar1,*,
- Patrick J. Lao3,
- Ansel T. Hillmer3,
- Todd E. Barnhart3,
- Bradley T. Christian3,
- Heather A. Mitchell4,
- Barbara B. Bendlin1,
- Matyas Sandor2, and
- Luigi Puglielli1,5
- 1Department of Medicine,
- 2Department of Pathology,
- 3Department of Medical Physics and Waisman Laboratory for Brain Imaging and Behavior, and
- 4Rodent Models Core, Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin 53705, and
- 5Geriatric Research Education Clinical Center, VA Medical Center, Madison, Wisconsin 53705
Author contributions
Author contributions: Y.P., M.L., B.D.C., M.P., P.J.L., B.T.C., M.S., and L.P. designed research; Y.P., M.L., B.D.C., M.P., P.J.L., A.T.H., T.E.B., and H.A.M. performed research; Y.P., M.L., B.D.C., M.P., P.J.L., A.T.H., T.E.B., B.T.C., H.A.M., B.B.B., M.S., and L.P. analyzed data; B.D.C., P.J.L., B.B.B., M.S., and L.P. wrote the paper.
↵*B.D.C. and M.P. contributed equally to this work.
Disclosures
- Received January 8, 2014.
- Revision received March 11, 2014.
- Accepted April 8, 2014.
This work was supported by the National Institutes of Health (L.P. and M.S.), the Department of Veterans Affairs (L.P.), and the Wisconsin Alzheimer's Disease Research Center (B.T.C.). We thank Carlos Hirschberg and Nansi Jo Colley for critical reading of an early version of this manuscript; Patricia Powers and the UW-Madison Transgenic Animal Facility for the generation of AT-1S113R/+ mice; Ruth Sullivan and Shahriar Salamat for help with the pathology; Joan M. Sempf and the VAH-EM Facility for morphology; Beth Meyerand, Beth Rauch, and Guan Koay for help with MRI; and Mohammed Farhoud and Sofie Biosciences for use of PET scanner.
The authors declare no competing financial interests.
- Correspondence should be addressed to Luigi Puglielli, Department of Medicine, University of Wisconsin-Madison, VAH-GRECC, 2500 Overlook Terrace, Madison, WI 53705. lp1{at}medicine.wisc.edu
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