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Articles, Neurobiology of Disease

Deficient Import of Acetyl-CoA into the ER Lumen Causes Neurodegeneration and Propensity to Infections, Inflammation, and Cancer

Yajing Peng, Mi Li, Ben D. Clarkson, Mariana Pehar, Patrick J. Lao, Ansel T. Hillmer, Todd E. Barnhart, Bradley T. Christian, Heather A. Mitchell, Barbara B. Bendlin, Matyas Sandor and Luigi Puglielli
Journal of Neuroscience 14 May 2014, 34 (20) 6772-6789; DOI: https://doi.org/10.1523/JNEUROSCI.0077-14.2014
Yajing Peng
1Department of Medicine,
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Mi Li
1Department of Medicine,
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Ben D. Clarkson
2Department of Pathology,
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Mariana Pehar
1Department of Medicine,
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Patrick J. Lao
3Department of Medical Physics and Waisman Laboratory for Brain Imaging and Behavior, and
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Ansel T. Hillmer
3Department of Medical Physics and Waisman Laboratory for Brain Imaging and Behavior, and
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Todd E. Barnhart
3Department of Medical Physics and Waisman Laboratory for Brain Imaging and Behavior, and
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Bradley T. Christian
3Department of Medical Physics and Waisman Laboratory for Brain Imaging and Behavior, and
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Heather A. Mitchell
4Rodent Models Core, Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin 53705, and
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Barbara B. Bendlin
1Department of Medicine,
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Matyas Sandor
2Department of Pathology,
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Luigi Puglielli
1Department of Medicine,
5Geriatric Research Education Clinical Center, VA Medical Center, Madison, Wisconsin 53705
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0077-14.2014
PubMed 
24828632
Published By 
Society for Neuroscience
History 
  • Received January 8, 2014
  • Revision received March 11, 2014
  • Accepted April 8, 2014
  • First published May 14, 2014.
  • Version of record published May 14, 2014.
Copyright & Usage 
Copyright © 2014 the authors 0270-6474/14/346772-18$15.00/0

Author Information

  1. Yajing Peng1,
  2. Mi Li1,
  3. Ben D. Clarkson2,*,
  4. Mariana Pehar1,*,
  5. Patrick J. Lao3,
  6. Ansel T. Hillmer3,
  7. Todd E. Barnhart3,
  8. Bradley T. Christian3,
  9. Heather A. Mitchell4,
  10. Barbara B. Bendlin1,
  11. Matyas Sandor2, and
  12. Luigi Puglielli1,5
  1. 1Department of Medicine,
  2. 2Department of Pathology,
  3. 3Department of Medical Physics and Waisman Laboratory for Brain Imaging and Behavior, and
  4. 4Rodent Models Core, Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin 53705, and
  5. 5Geriatric Research Education Clinical Center, VA Medical Center, Madison, Wisconsin 53705
  • M. Pehar's present address: Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29425.

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Author contributions

  1. Author contributions: Y.P., M.L., B.D.C., M.P., P.J.L., B.T.C., M.S., and L.P. designed research; Y.P., M.L., B.D.C., M.P., P.J.L., A.T.H., T.E.B., and H.A.M. performed research; Y.P., M.L., B.D.C., M.P., P.J.L., A.T.H., T.E.B., B.T.C., H.A.M., B.B.B., M.S., and L.P. analyzed data; B.D.C., P.J.L., B.B.B., M.S., and L.P. wrote the paper.

  2. ↵*B.D.C. and M.P. contributed equally to this work.

  • M. Pehar's present address: Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29425.

Disclosures

    • Received January 8, 2014.
    • Revision received March 11, 2014.
    • Accepted April 8, 2014.
  • This work was supported by the National Institutes of Health (L.P. and M.S.), the Department of Veterans Affairs (L.P.), and the Wisconsin Alzheimer's Disease Research Center (B.T.C.). We thank Carlos Hirschberg and Nansi Jo Colley for critical reading of an early version of this manuscript; Patricia Powers and the UW-Madison Transgenic Animal Facility for the generation of AT-1S113R/+ mice; Ruth Sullivan and Shahriar Salamat for help with the pathology; Joan M. Sempf and the VAH-EM Facility for morphology; Beth Meyerand, Beth Rauch, and Guan Koay for help with MRI; and Mohammed Farhoud and Sofie Biosciences for use of PET scanner.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Luigi Puglielli, Department of Medicine, University of Wisconsin-Madison, VAH-GRECC, 2500 Overlook Terrace, Madison, WI 53705. lp1{at}medicine.wisc.edu

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Article usage: May 2014 to July 2022

AbstractFullPdf
May 2014190674138
Jun 20142553938
Jul 20141833122
Aug 2014561616
Sep 2014812622
Oct 2014753323
Nov 2014471817
Dec 2014331718
Total 20142636254294
Jan 2015563723
Feb 2015343012
Mar 2015412414
Apr 201534219
May 2015344613
Jun 2015284813
Jul 2015372415
Aug 2015382015
Sep 2015312817
Oct 2015392513
Nov 2015392012
Dec 201525257
Total 2015436348163
Jan 2016341915
Feb 201637139
Mar 2016372123
Apr 2016211817
May 2016231819
Jun 2016262316
Jul 2016301712
Aug 2016363210
Sep 2016391715
Oct 2016172116
Nov 2016155326
Dec 20167299
Total 2016322281187
Jan 201744230
Feb 201733115
Mar 2017125913
Apr 201720208
May 201714299
Jun 201704613
Jul 2017111738
Aug 201722713
Sep 201763225
Oct 201713710
Nov 2017143513
Dec 20170226
Total 201787397193
Jan 201862812
Feb 201862422
Mar 201853214
Apr 201824115
May 201834111
Jun 201813212
Jul 20184279
Aug 20185315
Sep 20186266
Oct 20185274
Nov 20183339
Dec 20183224
Total 201849364123
Jan 20194409
Feb 201910256
Mar 201963010
Apr 201932713
May 201923712
Jun 20198315
Jul 201964614
Aug 20198595
Sep 201933011
Oct 20198308
Nov 201973914
Dec 20198164
Total 201973410111
Jan 202048312
Feb 20200518
Mar 202062910
Apr 202094426
May 202044920
Jun 202013010
Jul 20205249
Aug 202042515
Sep 2020113010
Oct 202044718
Nov 2020113312
Dec 2020103812
Total 202069483162
Jan 2021104017
Feb 202184114
Mar 2021115223
Apr 20214389
May 2021102613
Jun 202134113
Jul 202133010
Aug 202162514
Sep 2021133216
Oct 202134524
Nov 202132425
Dec 20212224
Total 202176416182
Jan 20224215
Feb 202252710
Mar 202222312
Apr 202213411
May 202224421
Jun 202222913
Jul 2022010
Total 20221617972
Total376431321487
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The Journal of Neuroscience: 34 (20)
Journal of Neuroscience
Vol. 34, Issue 20
14 May 2014
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Deficient Import of Acetyl-CoA into the ER Lumen Causes Neurodegeneration and Propensity to Infections, Inflammation, and Cancer
Yajing Peng, Mi Li, Ben D. Clarkson, Mariana Pehar, Patrick J. Lao, Ansel T. Hillmer, Todd E. Barnhart, Bradley T. Christian, Heather A. Mitchell, Barbara B. Bendlin, Matyas Sandor, Luigi Puglielli
Journal of Neuroscience 14 May 2014, 34 (20) 6772-6789; DOI: 10.1523/JNEUROSCI.0077-14.2014

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Deficient Import of Acetyl-CoA into the ER Lumen Causes Neurodegeneration and Propensity to Infections, Inflammation, and Cancer
Yajing Peng, Mi Li, Ben D. Clarkson, Mariana Pehar, Patrick J. Lao, Ansel T. Hillmer, Todd E. Barnhart, Bradley T. Christian, Heather A. Mitchell, Barbara B. Bendlin, Matyas Sandor, Luigi Puglielli
Journal of Neuroscience 14 May 2014, 34 (20) 6772-6789; DOI: 10.1523/JNEUROSCI.0077-14.2014
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