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PreviousNext
Featured ArticleArticles, Neurobiology of Disease

1α,25-Dihydroxyvitamin D3 Reduces Cerebral Amyloid-β Accumulation and Improves Cognition in Mouse Models of Alzheimer's Disease

Matthew R. Durk, Kyung Han, Edwin C. Y. Chow, Rosemary Ahrens, Jeffrey T. Henderson, Paul E. Fraser and K. Sandy Pang
Journal of Neuroscience 21 May 2014, 34 (21) 7091-7101; https://doi.org/10.1523/JNEUROSCI.2711-13.2014
Matthew R. Durk
1Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, Toronto, Ontario, Canada, M5S 3M2,
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Kyung Han
3Tanz Centre for Research in Neurodegenerative Diseases, Krembil Discovery Tower, Toronto, Ontario, Canada, M5T 2S8
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Edwin C. Y. Chow
1Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, Toronto, Ontario, Canada, M5S 3M2,
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Rosemary Ahrens
3Tanz Centre for Research in Neurodegenerative Diseases, Krembil Discovery Tower, Toronto, Ontario, Canada, M5T 2S8
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Jeffrey T. Henderson
1Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, Toronto, Ontario, Canada, M5S 3M2,
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Paul E. Fraser
2Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada, M5S 3H2, and
3Tanz Centre for Research in Neurodegenerative Diseases, Krembil Discovery Tower, Toronto, Ontario, Canada, M5T 2S8
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K. Sandy Pang
1Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, Toronto, Ontario, Canada, M5S 3M2,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2711-13.2014
PubMed 
24849345
Published By 
Society for Neuroscience
History 
  • Received June 26, 2013
  • Revision received April 2, 2014
  • Accepted April 10, 2014
  • First published May 21, 2014.
  • Version of record published May 21, 2014.
Copyright & Usage 
Copyright © 2014 the authors 0270-6474/14/347091-11$15.00/0

Author Information

  1. Matthew R. Durk1,
  2. Kyung Han3,
  3. Edwin C. Y. Chow1,
  4. Rosemary Ahrens3,
  5. Jeffrey T. Henderson1,
  6. Paul E. Fraser2,3, and
  7. K. Sandy Pang1
  1. 1Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, Toronto, Ontario, Canada, M5S 3M2,
  2. 2Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada, M5S 3H2, and
  3. 3Tanz Centre for Research in Neurodegenerative Diseases, Krembil Discovery Tower, Toronto, Ontario, Canada, M5T 2S8
View Full Text

Author contributions

  1. Author contributions: M.R.D., R.A., J.T.H., P.E.F., and K.S.P. designed research; M.R.D., K.H., R.A., and J.T.H. performed research; E.C.Y.C., R.A., J.T.H., P.E.F., and K.S.P. contributed unpublished reagents/analytic tools; M.R.D., K.H., R.A., and J.T.H. analyzed data; M.R.D., K.H., and K.S.P. wrote the paper.

Disclosures

    • Received June 26, 2013.
    • Revision received April 2, 2014.
    • Accepted April 10, 2014.
  • This work was supported by the Canadian Institutes of Health Research (CIHR) and the Alzheimer Society of Ontario. M.R.D. was supported by a CIHR Strategic Training Grant in Biological Therapeutics and Pfizer Canada Graduate Scholarship in Science and Technology. E.C.Y.C. was supported by the Natural Sciences and Engineering Research Council of Canada Alexander Graham Bell Fellowship. We thank Dr. Bingning Dong (Baylor College of Medicine, Texas Medical Center, Houston, TX) for discussion on immunostaining.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr. K. S. Pang, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario, Canada, M5S 3M2. ks.pang{at}utoronto.ca

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Jan 2018506127
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Apr 20213459
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Mar 202518519
Apr 2025116317
May 20256235
Total 20257423784
Total103551021324
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The Journal of Neuroscience: 34 (21)
Journal of Neuroscience
Vol. 34, Issue 21
21 May 2014
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1α,25-Dihydroxyvitamin D3 Reduces Cerebral Amyloid-β Accumulation and Improves Cognition in Mouse Models of Alzheimer's Disease
Matthew R. Durk, Kyung Han, Edwin C. Y. Chow, Rosemary Ahrens, Jeffrey T. Henderson, Paul E. Fraser, K. Sandy Pang
Journal of Neuroscience 21 May 2014, 34 (21) 7091-7101; DOI: 10.1523/JNEUROSCI.2711-13.2014

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1α,25-Dihydroxyvitamin D3 Reduces Cerebral Amyloid-β Accumulation and Improves Cognition in Mouse Models of Alzheimer's Disease
Matthew R. Durk, Kyung Han, Edwin C. Y. Chow, Rosemary Ahrens, Jeffrey T. Henderson, Paul E. Fraser, K. Sandy Pang
Journal of Neuroscience 21 May 2014, 34 (21) 7091-7101; DOI: 10.1523/JNEUROSCI.2711-13.2014
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Keywords

  • Alzheimer's
  • amyloid beta
  • blood-brain barrier
  • P-glycoprotein
  • vitamin D receptor

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