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Articles, Neurobiology of Disease

Ubiquitin-Activating Enzyme Activity Contributes to Differential Accumulation of Mutant Huntingtin in Brain and Peripheral Tissues

Brandy E. Wade, Chuan-En Wang, Sen Yan, Kavita Bhat, Brenda Huang, Shihua Li and Xiao-Jiang Li
Journal of Neuroscience 18 June 2014, 34 (25) 8411-8422; https://doi.org/10.1523/JNEUROSCI.0775-14.2014
Brandy E. Wade
1Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, and
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Chuan-En Wang
1Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, and
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Sen Yan
1Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, and
2State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Chaoyang District, Beijing 100101, People's Republic of China
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Kavita Bhat
1Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, and
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Brenda Huang
1Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, and
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Shihua Li
1Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, and
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Xiao-Jiang Li
1Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, and
2State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Chaoyang District, Beijing 100101, People's Republic of China
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The Journal of Neuroscience: 34 (25)
Journal of Neuroscience
Vol. 34, Issue 25
18 Jun 2014
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Ubiquitin-Activating Enzyme Activity Contributes to Differential Accumulation of Mutant Huntingtin in Brain and Peripheral Tissues
Brandy E. Wade, Chuan-En Wang, Sen Yan, Kavita Bhat, Brenda Huang, Shihua Li, Xiao-Jiang Li
Journal of Neuroscience 18 June 2014, 34 (25) 8411-8422; DOI: 10.1523/JNEUROSCI.0775-14.2014

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Ubiquitin-Activating Enzyme Activity Contributes to Differential Accumulation of Mutant Huntingtin in Brain and Peripheral Tissues
Brandy E. Wade, Chuan-En Wang, Sen Yan, Kavita Bhat, Brenda Huang, Shihua Li, Xiao-Jiang Li
Journal of Neuroscience 18 June 2014, 34 (25) 8411-8422; DOI: 10.1523/JNEUROSCI.0775-14.2014
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Keywords

  • misfolding
  • neurodegneration
  • ubiquitin

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