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Articles, Neurobiology of Disease

Ear2 Deletion Causes Early Memory and Learning Deficits in APP/PS1 Mice

Markus P. Kummer, Thea Hammerschmidt, Ana Martinez, Dick Terwel, Gregor Eichele, Anika Witten, Stefanie Figura, Monika Stoll, Stephanie Schwartz, Hans-Christian Pape, Joachim L. Schultze, David Weinshenker and Michael T. Heneka
Journal of Neuroscience 25 June 2014, 34 (26) 8845-8854; DOI: https://doi.org/10.1523/JNEUROSCI.4027-13.2014
Markus P. Kummer
1Department of Neurology, Clinical Neurosciences Unit, University of Bonn, 53127 Bonn, Germany,
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Thea Hammerschmidt
1Department of Neurology, Clinical Neurosciences Unit, University of Bonn, 53127 Bonn, Germany,
2Institute of Physiology I, Westfälische Wilhelms-University Münster, 48149 Münster, Germany,
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Ana Martinez
3Genes and Behavior Department, Max Planck Institute of Biophysical Chemistry, 37077 Göttingen, Germany,
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Dick Terwel
1Department of Neurology, Clinical Neurosciences Unit, University of Bonn, 53127 Bonn, Germany,
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Gregor Eichele
3Genes and Behavior Department, Max Planck Institute of Biophysical Chemistry, 37077 Göttingen, Germany,
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Anika Witten
5Leibniz-Institut für Arterioskleroseforschung, Genetische Epidemiologie vaskulärer Erkrankungen, 48149 Münster, Germany,
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Stefanie Figura
5Leibniz-Institut für Arterioskleroseforschung, Genetische Epidemiologie vaskulärer Erkrankungen, 48149 Münster, Germany,
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Monika Stoll
5Leibniz-Institut für Arterioskleroseforschung, Genetische Epidemiologie vaskulärer Erkrankungen, 48149 Münster, Germany,
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Stephanie Schwartz
1Department of Neurology, Clinical Neurosciences Unit, University of Bonn, 53127 Bonn, Germany,
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Hans-Christian Pape
2Institute of Physiology I, Westfälische Wilhelms-University Münster, 48149 Münster, Germany,
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Joachim L. Schultze
4LIMES Institute, Genomics and Immunoregulation, University of Bonn, 53115 Bonn, Germany,
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David Weinshenker
6Department of Human Genetics, Emory University, Atlanta, Georgia 30322, and
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Michael T. Heneka
1Department of Neurology, Clinical Neurosciences Unit, University of Bonn, 53127 Bonn, Germany,
7German Center for Neurodegenerative Diseases, 53127 Bonn, Germany
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4027-13.2014
PubMed 
24966384
Published By 
Society for Neuroscience
History 
  • Received September 16, 2013
  • Revision received April 3, 2014
  • Accepted April 21, 2014
  • First published June 25, 2014.
  • Version of record published June 25, 2014.
Copyright & Usage 
Copyright © 2014 the authors 0270-6474/14/348845-10$15.00/0

Author Information

  1. Markus P. Kummer1,*,
  2. Thea Hammerschmidt1,2,*,
  3. Ana Martinez3,
  4. Dick Terwel1,
  5. Gregor Eichele3,
  6. Anika Witten5,
  7. Stefanie Figura5,
  8. Monika Stoll5,
  9. Stephanie Schwartz1,
  10. Hans-Christian Pape2,
  11. Joachim L. Schultze4,
  12. David Weinshenker6, and
  13. Michael T. Heneka1,7
  1. 1Department of Neurology, Clinical Neurosciences Unit, University of Bonn, 53127 Bonn, Germany,
  2. 2Institute of Physiology I, Westfälische Wilhelms-University Münster, 48149 Münster, Germany,
  3. 3Genes and Behavior Department, Max Planck Institute of Biophysical Chemistry, 37077 Göttingen, Germany,
  4. 4LIMES Institute, Genomics and Immunoregulation, University of Bonn, 53115 Bonn, Germany,
  5. 5Leibniz-Institut für Arterioskleroseforschung, Genetische Epidemiologie vaskulärer Erkrankungen, 48149 Münster, Germany,
  6. 6Department of Human Genetics, Emory University, Atlanta, Georgia 30322, and
  7. 7German Center for Neurodegenerative Diseases, 53127 Bonn, Germany
View Full Text

Author contributions

  1. Author contributions: M.P.K., T.H., D.T., G.E., H.-C.P., J.L.S., D.W., and M.T.H. designed research; M.P.K., T.H., A.M., A.W., S.F., and S.S. performed research; M.P.K., T.H., A.M., D.T., A.W., S.F., and M.S. analyzed data; M.P.K., T.H., D.W., and M.T.H. wrote the paper.

  2. ↵*M.P.K. and T.H. contributed equally to this work.

Disclosures

    • Received September 16, 2013.
    • Revision received April 3, 2014.
    • Accepted April 21, 2014.
  • This work was supported by grants from the INMiND project and the Cluster of Excellence “ImmunoSensation” to M.T.H., the Interdisciplinary Center of Clinical Research (IZKF; HEN3/003/06) to M.T.H. and H.-C.P., the Institute for the Study of Aging to D.W., and a pilot grant from the Emory University Alzheimer's Disease Research Center (PHS AG025688) to D.W., M.T.H. is a member of the DFG Cluster of Excellence “ImmunoSensation.” We thank the Dainippon Sumitomo Pharmaceutical Company for the generous gift of l-threo DOPS. We also thank C. Jerome and C. Hülsmann for excellent technical assistance.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr. Michael T. Heneka, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany. michael.heneka{at}ukb.uni-bonn.de

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Article usage: June 2014 to May 2022

AbstractFullPdf
Jun 201414425493
Jul 20148586666
Aug 20141373223
Sep 20141194326
Oct 2014881912
Nov 201498149
Dec 2014562816
Total 20142798256245
Jan 2015682829
Feb 2015652921
Mar 2015493619
Apr 2015413215
May 201526316
Jun 201532175
Jul 201530128
Aug 20151499
Sep 201528159
Oct 2015451613
Nov 2015301010
Dec 201516108
Total 2015444245152
Jan 201630179
Feb 201630149
Mar 2016331219
Apr 2016221614
May 201628149
Jun 201615147
Jul 2016191812
Aug 2016201316
Sep 201616159
Oct 201617167
Nov 2016203222
Dec 201651711
Total 2016255198144
Jan 20179329
Feb 201742110
Mar 201711917
Apr 201793192
May 201712012
Jun 20173317
Jul 20171308
Aug 20175169
Sep 201752214
Oct 201751910
Nov 201711258
Dec 20173174
Total 201757283200
Jan 20185179
Feb 2018113911
Mar 201872814
Apr 201811368
May 20184305
Jun 20188399
Jul 2018122410
Aug 20183175
Sep 20186183
Oct 201818224
Nov 201892010
Dec 20185204
Total 20189931092
Jan 20197179
Feb 201912127
Mar 201911165
Apr 2019141413
May 201913166
Jun 201914129
Jul 2019111720
Aug 20196168
Sep 201913159
Oct 20193158
Nov 20196199
Dec 2019122111
Total 2019122190114
Jan 20206206
Feb 20206125
Mar 20208218
Apr 202033712
May 20209136
Jun 2020376
Jul 2020386
Aug 2020484
Sep 20204163
Oct 202013427
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Dec 20205309
Total 202058227100
Jan 202171411
Feb 2021132120
Mar 202162616
Apr 202162316
May 202110228
Jun 20214189
Jul 202113223
Aug 2021102720
Sep 202183112
Oct 202172220
Nov 2021194032
Dec 202152718
Total 202196303205
Jan 20228179
Feb 20226198
Mar 202292212
Apr 20223196
May 202241418
Total 2022309153
Total395921031305
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The Journal of Neuroscience: 34 (26)
Journal of Neuroscience
Vol. 34, Issue 26
25 Jun 2014
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Ear2 Deletion Causes Early Memory and Learning Deficits in APP/PS1 Mice
Markus P. Kummer, Thea Hammerschmidt, Ana Martinez, Dick Terwel, Gregor Eichele, Anika Witten, Stefanie Figura, Monika Stoll, Stephanie Schwartz, Hans-Christian Pape, Joachim L. Schultze, David Weinshenker, Michael T. Heneka
Journal of Neuroscience 25 June 2014, 34 (26) 8845-8854; DOI: 10.1523/JNEUROSCI.4027-13.2014

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Ear2 Deletion Causes Early Memory and Learning Deficits in APP/PS1 Mice
Markus P. Kummer, Thea Hammerschmidt, Ana Martinez, Dick Terwel, Gregor Eichele, Anika Witten, Stefanie Figura, Monika Stoll, Stephanie Schwartz, Hans-Christian Pape, Joachim L. Schultze, David Weinshenker, Michael T. Heneka
Journal of Neuroscience 25 June 2014, 34 (26) 8845-8854; DOI: 10.1523/JNEUROSCI.4027-13.2014
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Keywords

  • Alzheimer
  • locus ceruleus
  • memory
  • neurodegeneration
  • noradrenaline

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