Cover legend: Artistic rendition of αβγ-synuclein knockout synapses, showing a deficit in cholera toxin-HRP positive vesicles (black vesicles). This experiment in synuclein-null neurons supports a physiological role for α-synuclein in synaptic vesicle endocytosis. For more information, see the article by Vargas et al. (pages 9364–9376).