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Articles, Neurobiology of Disease

Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson's Disease-Like Models

Dora Games, Elvira Valera, Brian Spencer, Edward Rockenstein, Michael Mante, Anthony Adame, Christina Patrick, Kiren Ubhi, Silke Nuber, Patricia Sacayon, Wagner Zago, Peter Seubert, Robin Barbour, Dale Schenk and Eliezer Masliah
Journal of Neuroscience 9 July 2014, 34 (28) 9441-9454; https://doi.org/10.1523/JNEUROSCI.5314-13.2014
Dora Games
1Prothena Biosciences, South San Francisco, California 94080, and
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Elvira Valera
2Department of Neurosciences and
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Brian Spencer
2Department of Neurosciences and
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Edward Rockenstein
2Department of Neurosciences and
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Michael Mante
2Department of Neurosciences and
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Anthony Adame
2Department of Neurosciences and
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Christina Patrick
2Department of Neurosciences and
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Kiren Ubhi
2Department of Neurosciences and
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Silke Nuber
2Department of Neurosciences and
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Patricia Sacayon
1Prothena Biosciences, South San Francisco, California 94080, and
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Wagner Zago
1Prothena Biosciences, South San Francisco, California 94080, and
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Peter Seubert
1Prothena Biosciences, South San Francisco, California 94080, and
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Robin Barbour
1Prothena Biosciences, South San Francisco, California 94080, and
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Dale Schenk
1Prothena Biosciences, South San Francisco, California 94080, and
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Eliezer Masliah
2Department of Neurosciences and
3Department of Pathology, University of California, San Diego, La Jolla, California 92093
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.5314-13.2014
PubMed 
25009275
Published By 
Society for Neuroscience
History 
  • Received December 19, 2013
  • Revision received June 7, 2014
  • Accepted June 10, 2014
  • First published July 9, 2014.
  • Version of record published July 9, 2014.
Copyright & Usage 
Copyright © 2014 the authors 0270-6474/14/349441-14$15.00/0

Author Information

  1. Dora Games1,
  2. Elvira Valera2,
  3. Brian Spencer2,
  4. Edward Rockenstein2,
  5. Michael Mante2,
  6. Anthony Adame2,
  7. Christina Patrick2,
  8. Kiren Ubhi2,
  9. Silke Nuber2,
  10. Patricia Sacayon1,
  11. Wagner Zago1,
  12. Peter Seubert1,
  13. Robin Barbour1,
  14. Dale Schenk1, and
  15. Eliezer Masliah2,3
  1. 1Prothena Biosciences, South San Francisco, California 94080, and
  2. 2Department of Neurosciences and
  3. 3Department of Pathology, University of California, San Diego, La Jolla, California 92093
View Full Text

Author contributions

  1. Author contributions: D.G., E.V., B.S., E.R., K.U., S.N., P. Seubert, R.B., D.S., and E.M. designed research; E.V., B.S., E.R., M.M., A.A., C.P., P. Sacayon, R.B., and E.M. performed research; E.M. contributed unpublished reagents/analytic tools; D.G., E.V., B.S., E.R., K.U., S.N., P. Sacayon, W.Z., P. Seubert, R.B., and E.M. analyzed data; D.G., E.V., S.N., W.Z., P. Seubert, D.S., and E.M. wrote the paper.

Disclosures

    • Received December 19, 2013.
    • Revision received June 7, 2014.
    • Accepted June 10, 2014.
  • This work was supported by the National Institutes of Health (Grants AG11385, AG18840, AG022074, and NS044233) and Prothena Biosciences.

  • D.G., P.S., W.Z., P.S., R.B., and D.S. are employees of Prothena, the company that develops the antibodies described in the manuscript. The remaining authors declare no competing financial interests.

  • Correspondence should be addressed to Eliezer Masliah, M.D. University of California–San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0624. emasliah{at}ucsd.edu

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Total 202567544232
Total151481602892
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The Journal of Neuroscience: 34 (28)
Journal of Neuroscience
Vol. 34, Issue 28
9 Jul 2014
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Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson's Disease-Like Models
Dora Games, Elvira Valera, Brian Spencer, Edward Rockenstein, Michael Mante, Anthony Adame, Christina Patrick, Kiren Ubhi, Silke Nuber, Patricia Sacayon, Wagner Zago, Peter Seubert, Robin Barbour, Dale Schenk, Eliezer Masliah
Journal of Neuroscience 9 July 2014, 34 (28) 9441-9454; DOI: 10.1523/JNEUROSCI.5314-13.2014

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Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson's Disease-Like Models
Dora Games, Elvira Valera, Brian Spencer, Edward Rockenstein, Michael Mante, Anthony Adame, Christina Patrick, Kiren Ubhi, Silke Nuber, Patricia Sacayon, Wagner Zago, Peter Seubert, Robin Barbour, Dale Schenk, Eliezer Masliah
Journal of Neuroscience 9 July 2014, 34 (28) 9441-9454; DOI: 10.1523/JNEUROSCI.5314-13.2014
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Keywords

  • α-synuclein
  • α-synuclein propagation
  • α-synuclein truncation
  • calpain
  • immunotherapy
  • Parkinson's disease

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