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Articles, Neurobiology of Disease

Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson's Disease-Like Models

Dora Games, Elvira Valera, Brian Spencer, Edward Rockenstein, Michael Mante, Anthony Adame, Christina Patrick, Kiren Ubhi, Silke Nuber, Patricia Sacayon, Wagner Zago, Peter Seubert, Robin Barbour, Dale Schenk and Eliezer Masliah
Journal of Neuroscience 9 July 2014, 34 (28) 9441-9454; https://doi.org/10.1523/JNEUROSCI.5314-13.2014
Dora Games
1Prothena Biosciences, South San Francisco, California 94080, and
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Elvira Valera
2Department of Neurosciences and
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Brian Spencer
2Department of Neurosciences and
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Edward Rockenstein
2Department of Neurosciences and
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Michael Mante
2Department of Neurosciences and
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Anthony Adame
2Department of Neurosciences and
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Christina Patrick
2Department of Neurosciences and
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Kiren Ubhi
2Department of Neurosciences and
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Silke Nuber
2Department of Neurosciences and
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Patricia Sacayon
1Prothena Biosciences, South San Francisco, California 94080, and
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Wagner Zago
1Prothena Biosciences, South San Francisco, California 94080, and
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Peter Seubert
1Prothena Biosciences, South San Francisco, California 94080, and
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Robin Barbour
1Prothena Biosciences, South San Francisco, California 94080, and
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Dale Schenk
1Prothena Biosciences, South San Francisco, California 94080, and
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Eliezer Masliah
2Department of Neurosciences and
3Department of Pathology, University of California, San Diego, La Jolla, California 92093
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The Journal of Neuroscience: 34 (28)
Journal of Neuroscience
Vol. 34, Issue 28
9 Jul 2014
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Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson's Disease-Like Models
Dora Games, Elvira Valera, Brian Spencer, Edward Rockenstein, Michael Mante, Anthony Adame, Christina Patrick, Kiren Ubhi, Silke Nuber, Patricia Sacayon, Wagner Zago, Peter Seubert, Robin Barbour, Dale Schenk, Eliezer Masliah
Journal of Neuroscience 9 July 2014, 34 (28) 9441-9454; DOI: 10.1523/JNEUROSCI.5314-13.2014

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Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson's Disease-Like Models
Dora Games, Elvira Valera, Brian Spencer, Edward Rockenstein, Michael Mante, Anthony Adame, Christina Patrick, Kiren Ubhi, Silke Nuber, Patricia Sacayon, Wagner Zago, Peter Seubert, Robin Barbour, Dale Schenk, Eliezer Masliah
Journal of Neuroscience 9 July 2014, 34 (28) 9441-9454; DOI: 10.1523/JNEUROSCI.5314-13.2014
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Keywords

  • α-synuclein
  • α-synuclein propagation
  • α-synuclein truncation
  • calpain
  • immunotherapy
  • Parkinson's disease

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