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Featured ArticleArticles, Behavioral/Cognitive

Epigenetic Modification of the Glucocorticoid Receptor Gene Is Linked to Traumatic Memory and Post-Traumatic Stress Disorder Risk in Genocide Survivors

Vanja Vukojevic, Iris-T. Kolassa, Matthias Fastenrath, Leo Gschwind, Klara Spalek, Annette Milnik, Angela Heck, Christian Vogler, Sarah Wilker, Philippe Demougin, Fabian Peter, Erika Atucha, Attila Stetak, Benno Roozendaal, Thomas Elbert, Andreas Papassotiropoulos and Dominique J.-F. de Quervain
Journal of Neuroscience 30 July 2014, 34 (31) 10274-10284; https://doi.org/10.1523/JNEUROSCI.1526-14.2014
Vanja Vukojevic
1Department of Psychology, Division of Molecular Neuroscience, University of Basel, CH-4055 Basel, Switzerland,
2Department Biozentrum, Life Sciences Training Facility, University of Basel, CH-4056 Basel, Switzerland,
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Iris-T. Kolassa
3Clinical & Biological Psychology, Institute of Psychology and Education, University of Ulm, D-89069 Ulm, Germany,
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Matthias Fastenrath
1Department of Psychology, Division of Molecular Neuroscience, University of Basel, CH-4055 Basel, Switzerland,
4Department of Psychology, Division of Cognitive Neuroscience, University of Basel, CH-4055 Basel, Switzerland,
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Leo Gschwind
1Department of Psychology, Division of Molecular Neuroscience, University of Basel, CH-4055 Basel, Switzerland,
4Department of Psychology, Division of Cognitive Neuroscience, University of Basel, CH-4055 Basel, Switzerland,
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Klara Spalek
1Department of Psychology, Division of Molecular Neuroscience, University of Basel, CH-4055 Basel, Switzerland,
4Department of Psychology, Division of Cognitive Neuroscience, University of Basel, CH-4055 Basel, Switzerland,
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Annette Milnik
1Department of Psychology, Division of Molecular Neuroscience, University of Basel, CH-4055 Basel, Switzerland,
5Psychiatric University Clinics, University of Basel, CH-4012 Basel, Switzerland,
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Angela Heck
1Department of Psychology, Division of Molecular Neuroscience, University of Basel, CH-4055 Basel, Switzerland,
5Psychiatric University Clinics, University of Basel, CH-4012 Basel, Switzerland,
6Transfacultary Research Platform, University of Basel, CH-4055 Basel, Switzerland,
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Christian Vogler
1Department of Psychology, Division of Molecular Neuroscience, University of Basel, CH-4055 Basel, Switzerland,
5Psychiatric University Clinics, University of Basel, CH-4012 Basel, Switzerland,
6Transfacultary Research Platform, University of Basel, CH-4055 Basel, Switzerland,
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Sarah Wilker
3Clinical & Biological Psychology, Institute of Psychology and Education, University of Ulm, D-89069 Ulm, Germany,
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  • ORCID record for Sarah Wilker
Philippe Demougin
1Department of Psychology, Division of Molecular Neuroscience, University of Basel, CH-4055 Basel, Switzerland,
2Department Biozentrum, Life Sciences Training Facility, University of Basel, CH-4056 Basel, Switzerland,
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Fabian Peter
1Department of Psychology, Division of Molecular Neuroscience, University of Basel, CH-4055 Basel, Switzerland,
2Department Biozentrum, Life Sciences Training Facility, University of Basel, CH-4056 Basel, Switzerland,
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Erika Atucha
7Department of Cognitive Neuroscience and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 EZ Nijmegen, Netherlands, and
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Attila Stetak
1Department of Psychology, Division of Molecular Neuroscience, University of Basel, CH-4055 Basel, Switzerland,
2Department Biozentrum, Life Sciences Training Facility, University of Basel, CH-4056 Basel, Switzerland,
5Psychiatric University Clinics, University of Basel, CH-4012 Basel, Switzerland,
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Benno Roozendaal
7Department of Cognitive Neuroscience and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 EZ Nijmegen, Netherlands, and
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Thomas Elbert
8Clinical Psychology and Neuropsychology, University of Konstanz, D-78464 Konstanz, Germany
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Andreas Papassotiropoulos
1Department of Psychology, Division of Molecular Neuroscience, University of Basel, CH-4055 Basel, Switzerland,
2Department Biozentrum, Life Sciences Training Facility, University of Basel, CH-4056 Basel, Switzerland,
5Psychiatric University Clinics, University of Basel, CH-4012 Basel, Switzerland,
6Transfacultary Research Platform, University of Basel, CH-4055 Basel, Switzerland,
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Dominique J.-F. de Quervain
4Department of Psychology, Division of Cognitive Neuroscience, University of Basel, CH-4055 Basel, Switzerland,
5Psychiatric University Clinics, University of Basel, CH-4012 Basel, Switzerland,
6Transfacultary Research Platform, University of Basel, CH-4055 Basel, Switzerland,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1526-14.2014
PubMed 
25080589
Published By 
Society for Neuroscience
History 
  • Received April 15, 2014
  • Revision received June 14, 2014
  • Accepted June 18, 2014
  • First published July 30, 2014.
  • Version of record published July 30, 2014.
Copyright & Usage 
Copyright © 2014 the authors 0270-6474/14/3310274-11$15.00/0

Author Information

  1. Vanja Vukojevic1,2,
  2. Iris-T. Kolassa3,
  3. Matthias Fastenrath1,4,
  4. Leo Gschwind1,4,
  5. Klara Spalek1,4,
  6. Annette Milnik1,5,
  7. Angela Heck1,5,6,
  8. Christian Vogler1,5,6,
  9. Sarah Wilker3,
  10. Philippe Demougin1,2,
  11. Fabian Peter1,2,
  12. Erika Atucha7,
  13. Attila Stetak1,2,5,
  14. Benno Roozendaal7,
  15. Thomas Elbert8,
  16. Andreas Papassotiropoulos1,2,5,6, and
  17. Dominique J.-F. de Quervain4,5,6
  1. 1Department of Psychology, Division of Molecular Neuroscience, University of Basel, CH-4055 Basel, Switzerland,
  2. 2Department Biozentrum, Life Sciences Training Facility, University of Basel, CH-4056 Basel, Switzerland,
  3. 3Clinical & Biological Psychology, Institute of Psychology and Education, University of Ulm, D-89069 Ulm, Germany,
  4. 4Department of Psychology, Division of Cognitive Neuroscience, University of Basel, CH-4055 Basel, Switzerland,
  5. 5Psychiatric University Clinics, University of Basel, CH-4012 Basel, Switzerland,
  6. 6Transfacultary Research Platform, University of Basel, CH-4055 Basel, Switzerland,
  7. 7Department of Cognitive Neuroscience and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 EZ Nijmegen, Netherlands, and
  8. 8Clinical Psychology and Neuropsychology, University of Konstanz, D-78464 Konstanz, Germany
View Full Text

Author contributions

  1. Author contributions: V.V., I.-T.K., B.R., T.E., A.P., and D.J.-F.D.Q. designed research; V.V., I.-T.K., M.F., A.M., K.S., P.D., and F.P. performed research; V.V., P.D., F.P., T.E., A.P., and D.J.-F.D.Q. contributed unpublished reagents/analytic tools; V.V., I.-T.K., M.F., L.G., A.M., K.S., A.H., C.V., S.W., P.D., E.A., A.S., B.R., T.E., A.P., and D.J.-F.D.Q. analyzed data; V.V., I.-T.K., M.F., A.M., K.S., A.H., C.V., S.W., P.D., E.A., A.S., B.R., T.E., A.P., and D.J.-F.D.Q. wrote the paper.

Disclosures

    • Received April 15, 2014.
    • Revision received June 14, 2014.
    • Accepted June 18, 2014.
  • This work was supported by the Swiss National Science Foundation (Sinergia Grants CRSIK0_122691, CRSI33_130080 to D.J.-F.D.Q. and A.P.) and by the German Research Foundation (grants to I.-T.K. and T.E.). V.V. was supported by a Werner Siemens Foundation (Zug, Switzerland) PhD grant and Opportunities for Excellence PhD Program of the Biozentrum.

  • The authors declare no competing financial interest.

  • Correspondence should be addressed to either of the following: Vanja Vukojevic at the above address, vanja.vukojevic{at}unibas.ch; or Dominique J.-F. de Quervain at the above address, dominique.dequervain{at}unibas.ch

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The Journal of Neuroscience: 34 (31)
Journal of Neuroscience
Vol. 34, Issue 31
30 Jul 2014
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Epigenetic Modification of the Glucocorticoid Receptor Gene Is Linked to Traumatic Memory and Post-Traumatic Stress Disorder Risk in Genocide Survivors
Vanja Vukojevic, Iris-T. Kolassa, Matthias Fastenrath, Leo Gschwind, Klara Spalek, Annette Milnik, Angela Heck, Christian Vogler, Sarah Wilker, Philippe Demougin, Fabian Peter, Erika Atucha, Attila Stetak, Benno Roozendaal, Thomas Elbert, Andreas Papassotiropoulos, Dominique J.-F. de Quervain
Journal of Neuroscience 30 July 2014, 34 (31) 10274-10284; DOI: 10.1523/JNEUROSCI.1526-14.2014

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Epigenetic Modification of the Glucocorticoid Receptor Gene Is Linked to Traumatic Memory and Post-Traumatic Stress Disorder Risk in Genocide Survivors
Vanja Vukojevic, Iris-T. Kolassa, Matthias Fastenrath, Leo Gschwind, Klara Spalek, Annette Milnik, Angela Heck, Christian Vogler, Sarah Wilker, Philippe Demougin, Fabian Peter, Erika Atucha, Attila Stetak, Benno Roozendaal, Thomas Elbert, Andreas Papassotiropoulos, Dominique J.-F. de Quervain
Journal of Neuroscience 30 July 2014, 34 (31) 10274-10284; DOI: 10.1523/JNEUROSCI.1526-14.2014
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