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Articles, Systems/Circuits

Correlations in V1 Are Reduced by Stimulation Outside the Receptive Field

Adam C. Snyder, Michael J. Morais, Adam Kohn and Matthew A. Smith
Journal of Neuroscience 20 August 2014, 34 (34) 11222-11227; DOI: https://doi.org/10.1523/JNEUROSCI.0762-14.2014
Adam C. Snyder
1Department of Ophthalmology,
2Center for the Neural Basis of Cognition, and
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Michael J. Morais
1Department of Ophthalmology,
3Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, and
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Adam Kohn
4Dominick Purpura Department of Neuroscience and
5Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, New York, New York 10461
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Matthew A. Smith
1Department of Ophthalmology,
2Center for the Neural Basis of Cognition, and
3Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, and
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Abstract

The trial-to-trial response variability of nearby cortical neurons is correlated. These correlations may strongly influence population coding performance. Numerous studies have shown that correlations can be dynamically modified by attention, adaptation, learning, and potent stimulus drive. However, the mechanisms that influence correlation strength remain poorly understood. Here we test whether correlations are influenced by presenting stimuli outside the classical receptive field (RF) of visual neurons, where they recruit a normalization signal termed surround suppression. We recorded simultaneously the activity of dozens of cells using microelectrode arrays implanted in the superficial layers of V1 in anesthetized, paralyzed macaque monkeys. We presented annular stimuli that encircled—but did not impinge upon—the RFs of the recorded cells. We found that these “extra-classical” stimuli reduced correlations in the absence of stimulation of the RF, closely resembling the decorrelating effects of stimulating the RFs directly. Our results suggest that normalization signals may be an important mechanism for modulating correlations.

  • electrophysiology
  • extra-classical receptive field
  • population coding
  • spike count correlation
  • surround suppression
  • V1
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The Journal of Neuroscience: 34 (34)
Journal of Neuroscience
Vol. 34, Issue 34
20 Aug 2014
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Correlations in V1 Are Reduced by Stimulation Outside the Receptive Field
Adam C. Snyder, Michael J. Morais, Adam Kohn, Matthew A. Smith
Journal of Neuroscience 20 August 2014, 34 (34) 11222-11227; DOI: 10.1523/JNEUROSCI.0762-14.2014

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Correlations in V1 Are Reduced by Stimulation Outside the Receptive Field
Adam C. Snyder, Michael J. Morais, Adam Kohn, Matthew A. Smith
Journal of Neuroscience 20 August 2014, 34 (34) 11222-11227; DOI: 10.1523/JNEUROSCI.0762-14.2014
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Keywords

  • electrophysiology
  • extra-classical receptive field
  • population coding
  • spike count correlation
  • surround suppression
  • V1

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