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Articles, Development/Plasticity/Repair

Conditional Deletion of α-CaMKII Impairs Integration of Adult-Generated Granule Cells into Dentate Gyrus Circuits and Hippocampus-Dependent Learning

Maithe Arruda-Carvalho, Leonardo Restivo, Axel Guskjolen, Jonathan R. Epp, Ype Elgersma, Sheena A. Josselyn and Paul W. Frankland
Journal of Neuroscience 3 September 2014, 34 (36) 11919-11928; https://doi.org/10.1523/JNEUROSCI.0652-14.2014
Maithe Arruda-Carvalho
1Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada,
2Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada,
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  • ORCID record for Maithe Arruda-Carvalho
Leonardo Restivo
1Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada,
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Axel Guskjolen
1Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada,
3Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada,
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Jonathan R. Epp
1Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada,
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Ype Elgersma
4Department of Neuroscience, Erasmus MC University Medical Center, Rotterdam, The Netherlands, and
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Sheena A. Josselyn
1Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada,
2Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada,
3Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada,
5Department of Psychology, University of Toronto, Toronto, Ontario M5S 3G3, Canada
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Paul W. Frankland
1Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada,
2Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada,
3Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada,
5Department of Psychology, University of Toronto, Toronto, Ontario M5S 3G3, Canada
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0652-14.2014
PubMed 
25186740
Published By 
Society for Neuroscience
History 
  • Received February 14, 2014
  • Revision received July 21, 2014
  • Accepted July 24, 2014
  • First published September 3, 2014.
  • Version of record published September 3, 2014.
Copyright & Usage 
Copyright © 2014 the authors 0270-6474/14/3411919-10$15.00/0

Author Information

  1. Maithe Arruda-Carvalho1,2,
  2. Leonardo Restivo1,
  3. Axel Guskjolen1,3,
  4. Jonathan R. Epp1,
  5. Ype Elgersma4,
  6. Sheena A. Josselyn1,2,3,5, and
  7. Paul W. Frankland1,2,3,5
  1. 1Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada,
  2. 2Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada,
  3. 3Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada,
  4. 4Department of Neuroscience, Erasmus MC University Medical Center, Rotterdam, The Netherlands, and
  5. 5Department of Psychology, University of Toronto, Toronto, Ontario M5S 3G3, Canada
View Full Text

Author contributions

  1. Author contributions: M.A.-C., L.R., and P.W.F. designed research; M.A.-C., L.R., A.G., and J.R.E. performed research; Y.E. contributed unpublished reagents/analytic tools; M.A.-C., L.R., and A.G. analyzed data; M.A.-C., S.A.J., and P.W.F. wrote the paper.

Disclosures

    • Received February 14, 2014.
    • Revision received July 21, 2014.
    • Accepted July 24, 2014.
  • This work was supported by Canadian Institutes of Health Research Grant MOP86762 to P.W.F. and Grant MOP74650 to S.A.J. and Brain Canada to P.W.F., M.A.-C. was supported by fellowships from the Ontario Graduate Scholarship program and The Hospital for Sick Children. We thank R. Kageyama and I. Imayoshi for the nestin-CreERT2 mice; and B. Richards, G. Vetere, A. de Cristofaro, R. Braybon, M. Yamamoto, and M. Sakaguchi for discussions and technical assistance.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr. Paul W. Frankland, Program in Neurosciences and Mental Health, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada. paul.frankland{at}sickkids.ca

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The Journal of Neuroscience: 34 (36)
Journal of Neuroscience
Vol. 34, Issue 36
3 Sep 2014
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Conditional Deletion of α-CaMKII Impairs Integration of Adult-Generated Granule Cells into Dentate Gyrus Circuits and Hippocampus-Dependent Learning
Maithe Arruda-Carvalho, Leonardo Restivo, Axel Guskjolen, Jonathan R. Epp, Ype Elgersma, Sheena A. Josselyn, Paul W. Frankland
Journal of Neuroscience 3 September 2014, 34 (36) 11919-11928; DOI: 10.1523/JNEUROSCI.0652-14.2014

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Conditional Deletion of α-CaMKII Impairs Integration of Adult-Generated Granule Cells into Dentate Gyrus Circuits and Hippocampus-Dependent Learning
Maithe Arruda-Carvalho, Leonardo Restivo, Axel Guskjolen, Jonathan R. Epp, Ype Elgersma, Sheena A. Josselyn, Paul W. Frankland
Journal of Neuroscience 3 September 2014, 34 (36) 11919-11928; DOI: 10.1523/JNEUROSCI.0652-14.2014
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Keywords

  • CaMKII
  • adult neurogenesis
  • hippocampus

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