Article Information
- Received May 7, 2014
- Revision received July 11, 2014
- Accepted July 22, 2014
- First published September 3, 2014.
- Version of record published September 3, 2014.
Author Information
- Ye Zhang1,*,
- Kenian Chen2,3,*,
- Steven A. Sloan1,*,
- Mariko L. Bennett1,
- Anja R. Scholze1,
- Sean O'Keeffe4,
- Hemali P. Phatnani4,
- Paolo Guarnieri7,9,
- Christine Caneda1,
- Nadine Ruderisch5,
- Shuyun Deng2,3,
- Shane A. Liddelow1,6,
- Chaolin Zhang4,7,8,
- Richard Daneman5,
- Tom Maniatis4,
- Ben A. Barres1,†, and
- Jia Qian Wu2,3,†
- 1Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305-5125,
- 2The Vivian L. Smith Department of Neurosurgery, University of Texas Medical School at Houston, Houston, Texas 77057,
- 3Center for Stem Cell and Regenerative Medicine, University of Texas Brown Institute of Molecular Medicine, Houston, Texas 77057,
- 4Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032,
- 5Department of Anatomy, University of California, San Francisco, San Francisco, California 94143-0452,
- 6Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria, Australia 3010, and
- 7Department of Systems Biology,
- 8Center for Motor Neuron Biology and Disease, and
- 9Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032
Author contributions
Author contributions: Y.Z., S.A.S., M.L.B., R.D., T.M., B.A.B., and J.Q.W. designed research; Y.Z., S.A.S., M.L.B., A.R.S., C.C., N.R., and S.D. performed research; S.A.L. and C.Z. contributed unpublished reagents/analytic tools; Y.Z., K.C., S.A.S., M.L.B., S.O., H.P.P., and P.G. analyzed data; Y.Z., S.A.S., and B.A.B. wrote the paper.
↵*Y.Z., K.C., and S.A.S. contributed equally to this work.
↵†B.A.B. and J.Q.W. contributed equally to this work.
Disclosures
- Received May 7, 2014.
- Revision received July 11, 2014.
- Accepted July 22, 2014.
This work is supported by National Institutes of Health Grants R01 MH09955501 and R01 NS08170301 (B.A.B.), T32GM007365 with additional support from Stanford School of Medicine and its Medical Scientist Training Program (S.S.), and R00 GM95713 (C.Z.), a Berry Postdoctoral Fellowship (Y.Z.), and a National Health and Medical Research Council of Australia C. J. Martin Fellowship (S.L.). J.Q.W., K.C., and S.D. are supported by National Institutes of Health and the Staman Ogilvie Fund–Memorial Hermann Foundation. We thank Dr. Dritan Agalliu for Cldn5 expression plasmid and Vincent and Stella Coates for their generous support.
The authors declare no competing financial interests.
- Correspondence should be addressed to either of the following: Ye Zhang, Stanford University School of Medicine, Department of Neurobiology, 299 Campus Drive, Fairchild Building, Stanford, California 94305-5125, zhangye{at}stanford.edu; or Jia Qian Wu, University of Texas Medical School, 1825 Pressler Street, SRB-630.01, Houston, TX 77030. jiaqian.wu{at}uth.tmc.edu
