Cover legend: Confocal image of a hippocampal neuron grown on a glial cell microisland. The neuron was labeled with anti-MAP2 antibody (red). Blue staining (DAPI) identifies cell nuclei. Autaptic cultures of single hippocampal neurons were used to investigate the effects of intracellular accumulation of amyloid-β protein on glutamatergic synaptic transmission. For more details, see the article by Ripoli et al. (12893–12903).