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Featured ArticleArticles, Systems/Circuits

Serotonin Affects Movement Gain Control in the Spinal Cord

Kunlin Wei, Joshua I. Glaser, Linna Deng, Christopher K. Thompson, Ian H. Stevenson, Qining Wang, Thomas George Hornby, Charles J. Heckman and Konrad P. Kording
Journal of Neuroscience 17 September 2014, 34 (38) 12690-12700; DOI: https://doi.org/10.1523/JNEUROSCI.1855-14.2014
Kunlin Wei
1Department of Psychology, Peking University, Beijing, China 100871,
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Joshua I. Glaser
2Departments of Physical Medicine and Rehabilitation,
3Physiology, and
4Applied Mathematics, Northwestern University, Chicago, Illinois 60611,
5Rehabilitation Institute of Chicago, Chicago, Illinois 60611, and
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Linna Deng
1Department of Psychology, Peking University, Beijing, China 100871,
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Christopher K. Thompson
5Rehabilitation Institute of Chicago, Chicago, Illinois 60611, and
6Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois 60607
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Ian H. Stevenson
2Departments of Physical Medicine and Rehabilitation,
3Physiology, and
4Applied Mathematics, Northwestern University, Chicago, Illinois 60611,
5Rehabilitation Institute of Chicago, Chicago, Illinois 60611, and
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Qining Wang
1Department of Psychology, Peking University, Beijing, China 100871,
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Thomas George Hornby
2Departments of Physical Medicine and Rehabilitation,
3Physiology, and
4Applied Mathematics, Northwestern University, Chicago, Illinois 60611,
5Rehabilitation Institute of Chicago, Chicago, Illinois 60611, and
6Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois 60607
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Charles J. Heckman
2Departments of Physical Medicine and Rehabilitation,
3Physiology, and
4Applied Mathematics, Northwestern University, Chicago, Illinois 60611,
5Rehabilitation Institute of Chicago, Chicago, Illinois 60611, and
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Konrad P. Kording
2Departments of Physical Medicine and Rehabilitation,
3Physiology, and
4Applied Mathematics, Northwestern University, Chicago, Illinois 60611,
5Rehabilitation Institute of Chicago, Chicago, Illinois 60611, and
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Abstract

A fundamental challenge for the nervous system is to encode signals spanning many orders of magnitude with neurons of limited bandwidth. To meet this challenge, perceptual systems use gain control. However, whether the motor system uses an analogous mechanism is essentially unknown. Neuromodulators, such as serotonin, are prime candidates for gain control signals during force production. Serotonergic neurons project diffusely to motor pools, and, therefore, force production by one muscle should change the gain of others. Here we present behavioral and pharmaceutical evidence that serotonin modulates the input–output gain of motoneurons in humans. By selectively changing the efficacy of serotonin with drugs, we systematically modulated the amplitude of spinal reflexes. More importantly, force production in different limbs interacts systematically, as predicted by a spinal gain control mechanism. Psychophysics and pharmacology suggest that the motor system adopts gain control mechanisms, and serotonin is a primary driver for their implementation in force production.

  • efficient control
  • gain control
  • neuromodulation
  • pharmacology
  • serotonin
  • spinal cord
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The Journal of Neuroscience: 34 (38)
Journal of Neuroscience
Vol. 34, Issue 38
17 Sep 2014
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Serotonin Affects Movement Gain Control in the Spinal Cord
Kunlin Wei, Joshua I. Glaser, Linna Deng, Christopher K. Thompson, Ian H. Stevenson, Qining Wang, Thomas George Hornby, Charles J. Heckman, Konrad P. Kording
Journal of Neuroscience 17 September 2014, 34 (38) 12690-12700; DOI: 10.1523/JNEUROSCI.1855-14.2014

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Serotonin Affects Movement Gain Control in the Spinal Cord
Kunlin Wei, Joshua I. Glaser, Linna Deng, Christopher K. Thompson, Ian H. Stevenson, Qining Wang, Thomas George Hornby, Charles J. Heckman, Konrad P. Kording
Journal of Neuroscience 17 September 2014, 34 (38) 12690-12700; DOI: 10.1523/JNEUROSCI.1855-14.2014
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Keywords

  • efficient control
  • gain control
  • neuromodulation
  • pharmacology
  • serotonin
  • spinal cord

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