Cover legend: Composite image of immunofluorescence-labeled cultured neurons from lethargic (Ca_V β₄-null mutant) mice reconstituted with specific splice variants of the calcium channel β₄ subunit (shown on the background of a gene expression heat map). β_4b (blue) and β_4e (orange) both functionally interact with calcium channels in the membrane but possess strikingly different abilities to target into the nucleus and to regulate expression of neuronal genes including that of Ca_V2.1, the primary channel partner of b₄ subunits in cerebellar synapses. For more information, see the article by Etemad et al. (pages 1446–1461).