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Articles, Neurobiology of Disease

Impaired Contextual Modulation of Memories in PTSD: An fMRI and Psychophysiological Study of Extinction Retention and Fear Renewal

Sarah N. Garfinkel, James L. Abelson, Anthony P. King, Rebecca K. Sripada, Xin Wang, Laura M. Gaines and Israel Liberzon
Journal of Neuroscience 1 October 2014, 34 (40) 13435-13443; https://doi.org/10.1523/JNEUROSCI.4287-13.2014
Sarah N. Garfinkel
1University of Michigan, Department of Psychiatry, Ann Arbor, Michigan 48109-2701,
2Brighton and Sussex Medical School, Department of Psychiatry, Falmer BN1 9RR, United Kingdom, and
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James L. Abelson
1University of Michigan, Department of Psychiatry, Ann Arbor, Michigan 48109-2701,
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Anthony P. King
1University of Michigan, Department of Psychiatry, Ann Arbor, Michigan 48109-2701,
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Rebecca K. Sripada
1University of Michigan, Department of Psychiatry, Ann Arbor, Michigan 48109-2701,
3Ann Arbor Veterans Affairs, Michigan 48105
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Xin Wang
1University of Michigan, Department of Psychiatry, Ann Arbor, Michigan 48109-2701,
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Laura M. Gaines
1University of Michigan, Department of Psychiatry, Ann Arbor, Michigan 48109-2701,
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Israel Liberzon
1University of Michigan, Department of Psychiatry, Ann Arbor, Michigan 48109-2701,
3Ann Arbor Veterans Affairs, Michigan 48105
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4287-13.2014
PubMed 
25274821
Published By 
Society for Neuroscience
History 
  • Received October 1, 2013
  • Revision received July 16, 2014
  • Accepted August 11, 2014
  • First published October 1, 2014.
  • Version of record published October 1, 2014.
Copyright & Usage 
Copyright © 2014 the authors 0270-6474/14/3413435-09$15.00/0

Author Information

  1. Sarah N. Garfinkel1,2,
  2. James L. Abelson1,
  3. Anthony P. King1,
  4. Rebecca K. Sripada1,3,
  5. Xin Wang1,
  6. Laura M. Gaines1, and
  7. Israel Liberzon1,3
  1. 1University of Michigan, Department of Psychiatry, Ann Arbor, Michigan 48109-2701,
  2. 2Brighton and Sussex Medical School, Department of Psychiatry, Falmer BN1 9RR, United Kingdom, and
  3. 3Ann Arbor Veterans Affairs, Michigan 48105
View Full Text

Author contributions

  1. Author contributions: S.N.G. and I.L. designed research; S.N.G., A.P.K., R.K.S., and X.W. performed research; S.N.G., A.P.K., R.K.S., X.W., L.M.G., and I.L. analyzed data; S.N.G., J.L.A., and I.L. wrote the paper.

Disclosures

    • Received October 1, 2013.
    • Revision received July 16, 2014.
    • Accepted August 11, 2014.
  • The research reported in this article was supported by grants from the Michigan Institute for Clinical and Health Research (U028028) to S.N.G., the National Institute of Mental Health (R24 MH075999) to I.L., from the Telemedicine and Advanced Technology Research Center (W81XWH-08-2-0208) to I.L. and A.P.K., from the University of Michigan Center for Computational Medicine and Bioinformatics Pilot Grant Program to A.P.K. We thank Nicholas Giardino who provided assistance with psychophysiological data acquisition and Mike Angstadt who provided expert assistance with fMRI data analyses.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr Sarah N. Garfinkel, Clinical Science Imaging Centre, Brighton and Sussex Medical School, University of Sussex, Falmer, BN1 9RR, UK. s.garfinkel{at}bsms.ac.uk

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Total 2025203668312
Total291462013821
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The Journal of Neuroscience: 34 (40)
Journal of Neuroscience
Vol. 34, Issue 40
1 Oct 2014
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Impaired Contextual Modulation of Memories in PTSD: An fMRI and Psychophysiological Study of Extinction Retention and Fear Renewal
Sarah N. Garfinkel, James L. Abelson, Anthony P. King, Rebecca K. Sripada, Xin Wang, Laura M. Gaines, Israel Liberzon
Journal of Neuroscience 1 October 2014, 34 (40) 13435-13443; DOI: 10.1523/JNEUROSCI.4287-13.2014

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Impaired Contextual Modulation of Memories in PTSD: An fMRI and Psychophysiological Study of Extinction Retention and Fear Renewal
Sarah N. Garfinkel, James L. Abelson, Anthony P. King, Rebecca K. Sripada, Xin Wang, Laura M. Gaines, Israel Liberzon
Journal of Neuroscience 1 October 2014, 34 (40) 13435-13443; DOI: 10.1523/JNEUROSCI.4287-13.2014
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Keywords

  • amygdala
  • context
  • fear conditioning
  • hippocampus
  • imaging
  • memory

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