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Articles, Neurobiology of Disease

Alpha-Band Hypersynchronization in Progressive Mild Cognitive Impairment: A Magnetoencephalography Study

María Eugenía López, Ricardo Bruña, Sara Aurtenetxe, José Ángel Pineda-Pardo, Alberto Marcos, Juan Arrazola, Ana Isabel Reinoso, Pedro Montejo, Ricardo Bajo and Fernando Maestú
Journal of Neuroscience 29 October 2014, 34 (44) 14551-14559; https://doi.org/10.1523/JNEUROSCI.0964-14.2014
María Eugenía López
1Laboratories of Cognitive and Computational Neuroscience (Complutense University of Madrid–Universidad Politécnica of Madrid) and
2Department of Basic Psychology II, Complutense University of Madrid (UCM), 28040 Madrid, Spain,
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Ricardo Bruña
1Laboratories of Cognitive and Computational Neuroscience (Complutense University of Madrid–Universidad Politécnica of Madrid) and
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Sara Aurtenetxe
1Laboratories of Cognitive and Computational Neuroscience (Complutense University of Madrid–Universidad Politécnica of Madrid) and
2Department of Basic Psychology II, Complutense University of Madrid (UCM), 28040 Madrid, Spain,
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José Ángel Pineda-Pardo
1Laboratories of Cognitive and Computational Neuroscience (Complutense University of Madrid–Universidad Politécnica of Madrid) and
3Laboratory of Neuroimaging (Universidad Politécnica de Madrid) (National Pedagogic University), Centre for Biomedical Technology (CTB), 28223 Madrid, Spain,
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Alberto Marcos
4Departments of Neurology and
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Juan Arrazola
5Radiology, San Carlos University Hospital, 28040 Madrid, Spain,
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Ana Isabel Reinoso
6Centre for Prevention of Cognitive Impairment, Madrid Health, 28006, Madrid, Spain, and
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Pedro Montejo
6Centre for Prevention of Cognitive Impairment, Madrid Health, 28006, Madrid, Spain, and
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Ricardo Bajo
1Laboratories of Cognitive and Computational Neuroscience (Complutense University of Madrid–Universidad Politécnica of Madrid) and
7Department of Mathematics, International University of La Rioja (UNIR), 26006 Logroño, Spain
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Fernando Maestú
1Laboratories of Cognitive and Computational Neuroscience (Complutense University of Madrid–Universidad Politécnica of Madrid) and
2Department of Basic Psychology II, Complutense University of Madrid (UCM), 28040 Madrid, Spain,
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Abstract

People with mild cognitive impairment (MCI) show a high risk to develop Alzheimer's disease (AD; Petersen et al., 2001). Nonetheless, there is a lack of studies about how functional connectivity patterns may distinguish between progressive (pMCI) and stable (sMCI) MCI patients. To examine whether there were differences in functional connectivity between groups, MEG eyes-closed recordings from 30 sMCI and 19 pMCI subjects were compared. The average conversion time of pMCI was 1 year, so they were considered as fast converters. To this end, functional connectivity in different frequency bands was assessed with phase locking value in source space. Then the significant differences between both groups were correlated with neuropsychological scores and entorhinal, parahippocampal, and hippocampal volumes. Both groups did not differ in age, gender, or educational level. pMCI patients obtained lower scores in episodic and semantic memory and also in executive functioning. At the structural level, there were no differences in hippocampal volume, although some were found in left entorhinal volume between both groups. Additionally, pMCI patients exhibit a higher synchronization in the alpha band between the right anterior cingulate and temporo-occipital regions than sMCI subjects. This hypersynchronization was inversely correlated with cognitive performance, both hippocampal volumes, and left entorhinal volume. The increase in phase synchronization between the right anterior cingulate and temporo-occipital areas may be predictive of conversion from MCI to AD.

  • alpha band
  • anterior cingulate
  • functional connectivity
  • MEG
  • mild cognitive impairment
  • phase locking value
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The Journal of Neuroscience: 34 (44)
Journal of Neuroscience
Vol. 34, Issue 44
29 Oct 2014
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Alpha-Band Hypersynchronization in Progressive Mild Cognitive Impairment: A Magnetoencephalography Study
María Eugenía López, Ricardo Bruña, Sara Aurtenetxe, José Ángel Pineda-Pardo, Alberto Marcos, Juan Arrazola, Ana Isabel Reinoso, Pedro Montejo, Ricardo Bajo, Fernando Maestú
Journal of Neuroscience 29 October 2014, 34 (44) 14551-14559; DOI: 10.1523/JNEUROSCI.0964-14.2014

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Alpha-Band Hypersynchronization in Progressive Mild Cognitive Impairment: A Magnetoencephalography Study
María Eugenía López, Ricardo Bruña, Sara Aurtenetxe, José Ángel Pineda-Pardo, Alberto Marcos, Juan Arrazola, Ana Isabel Reinoso, Pedro Montejo, Ricardo Bajo, Fernando Maestú
Journal of Neuroscience 29 October 2014, 34 (44) 14551-14559; DOI: 10.1523/JNEUROSCI.0964-14.2014
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Keywords

  • alpha band
  • anterior cingulate
  • functional connectivity
  • MEG
  • mild cognitive impairment
  • phase locking value

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