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Articles, Neurobiology of Disease

Alpha-Band Hypersynchronization in Progressive Mild Cognitive Impairment: A Magnetoencephalography Study

María Eugenía López, Ricardo Bruña, Sara Aurtenetxe, José Ángel Pineda-Pardo, Alberto Marcos, Juan Arrazola, Ana Isabel Reinoso, Pedro Montejo, Ricardo Bajo and Fernando Maestú
Journal of Neuroscience 29 October 2014, 34 (44) 14551-14559; https://doi.org/10.1523/JNEUROSCI.0964-14.2014
María Eugenía López
1Laboratories of Cognitive and Computational Neuroscience (Complutense University of Madrid–Universidad Politécnica of Madrid) and
2Department of Basic Psychology II, Complutense University of Madrid (UCM), 28040 Madrid, Spain,
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Ricardo Bruña
1Laboratories of Cognitive and Computational Neuroscience (Complutense University of Madrid–Universidad Politécnica of Madrid) and
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Sara Aurtenetxe
1Laboratories of Cognitive and Computational Neuroscience (Complutense University of Madrid–Universidad Politécnica of Madrid) and
2Department of Basic Psychology II, Complutense University of Madrid (UCM), 28040 Madrid, Spain,
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José Ángel Pineda-Pardo
1Laboratories of Cognitive and Computational Neuroscience (Complutense University of Madrid–Universidad Politécnica of Madrid) and
3Laboratory of Neuroimaging (Universidad Politécnica de Madrid) (National Pedagogic University), Centre for Biomedical Technology (CTB), 28223 Madrid, Spain,
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Alberto Marcos
4Departments of Neurology and
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Juan Arrazola
5Radiology, San Carlos University Hospital, 28040 Madrid, Spain,
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Ana Isabel Reinoso
6Centre for Prevention of Cognitive Impairment, Madrid Health, 28006, Madrid, Spain, and
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Pedro Montejo
6Centre for Prevention of Cognitive Impairment, Madrid Health, 28006, Madrid, Spain, and
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Ricardo Bajo
1Laboratories of Cognitive and Computational Neuroscience (Complutense University of Madrid–Universidad Politécnica of Madrid) and
7Department of Mathematics, International University of La Rioja (UNIR), 26006 Logroño, Spain
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Fernando Maestú
1Laboratories of Cognitive and Computational Neuroscience (Complutense University of Madrid–Universidad Politécnica of Madrid) and
2Department of Basic Psychology II, Complutense University of Madrid (UCM), 28040 Madrid, Spain,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0964-14.2014
PubMed 
25355209
Published By 
Society for Neuroscience
History 
  • Received March 11, 2014
  • Revision received July 30, 2014
  • Accepted August 2, 2014
  • First published October 29, 2014.
  • Version of record published October 29, 2014.
Copyright & Usage 
Copyright © 2014 the authors 0270-6474/14/3414551-09$15.00/0

Author Information

  1. María Eugenía López1,2,*,
  2. Ricardo Bruña1,*,
  3. Sara Aurtenetxe1,2,
  4. José Ángel Pineda-Pardo1,3,
  5. Alberto Marcos4,
  6. Juan Arrazola5,
  7. Ana Isabel Reinoso6,
  8. Pedro Montejo6,
  9. Ricardo Bajo1,7, and
  10. Fernando Maestú1,2
  1. 1Laboratories of Cognitive and Computational Neuroscience (Complutense University of Madrid–Universidad Politécnica of Madrid) and
  2. 2Department of Basic Psychology II, Complutense University of Madrid (UCM), 28040 Madrid, Spain,
  3. 3Laboratory of Neuroimaging (Universidad Politécnica de Madrid) (National Pedagogic University), Centre for Biomedical Technology (CTB), 28223 Madrid, Spain,
  4. 4Departments of Neurology and
  5. 5Radiology, San Carlos University Hospital, 28040 Madrid, Spain,
  6. 6Centre for Prevention of Cognitive Impairment, Madrid Health, 28006, Madrid, Spain, and
  7. 7Department of Mathematics, International University of La Rioja (UNIR), 26006 Logroño, Spain
View Full Text

Author contributions

  1. Author contributions: M.E.L., R.Br., S.A., A.M., and F.M. performed research; M.E.L., R.Br., and R.Ba. analyzed data; M.E.L., R.Br., and F.M. wrote the paper; M.E.L., S.A., A.M., J.A., A.I.R., P.M., and F.M. designed research; J.Á.P.-P. contributed unpublished reagents/analytic tools.

  2. ↵*M.E.L. and R.Br. contributed equally to this work.

Disclosures

    • Received March 11, 2014.
    • Revision received July 30, 2014.
    • Accepted August 2, 2014.
  • This study was partially supported by Spanish Ministry of Science and Economy Grants PSI2009-14415-C03-01 and PSI2012-38375-C03-01, Ministry of Education Predoctoral Fellowships FPU AP-2008-00175 (M.E.L.) and AP2010-1317 (J.A.P.-P.), and a predoctoral fellowship from the Basque Government (S.A.). We thank Pablo Cuesta and Pilar Garcés for their help concerning the methods used in this work.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to María Eugenia López, Laboratory of Cognitive and Computational Neuroscience (Complutense University of Madrid–Universidad Politécnica of Madrid), Centre for Biomedical Technology, Campus de Montegancedo s/n, 28223 Pozuelo de Alarcón, Madrid, Spain. meugenia.lopez{at}ctb.upm.es

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Total 20254820494
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The Journal of Neuroscience: 34 (44)
Journal of Neuroscience
Vol. 34, Issue 44
29 Oct 2014
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Alpha-Band Hypersynchronization in Progressive Mild Cognitive Impairment: A Magnetoencephalography Study
María Eugenía López, Ricardo Bruña, Sara Aurtenetxe, José Ángel Pineda-Pardo, Alberto Marcos, Juan Arrazola, Ana Isabel Reinoso, Pedro Montejo, Ricardo Bajo, Fernando Maestú
Journal of Neuroscience 29 October 2014, 34 (44) 14551-14559; DOI: 10.1523/JNEUROSCI.0964-14.2014

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Alpha-Band Hypersynchronization in Progressive Mild Cognitive Impairment: A Magnetoencephalography Study
María Eugenía López, Ricardo Bruña, Sara Aurtenetxe, José Ángel Pineda-Pardo, Alberto Marcos, Juan Arrazola, Ana Isabel Reinoso, Pedro Montejo, Ricardo Bajo, Fernando Maestú
Journal of Neuroscience 29 October 2014, 34 (44) 14551-14559; DOI: 10.1523/JNEUROSCI.0964-14.2014
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Keywords

  • alpha band
  • anterior cingulate
  • functional connectivity
  • MEG
  • mild cognitive impairment
  • phase locking value

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