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Articles, Systems/Circuits

Sleep Restriction Impairs Blood–Brain Barrier Function

Junyun He, Hung Hsuchou, Yi He, Abba J. Kastin, Yuping Wang and Weihong Pan
Journal of Neuroscience 29 October 2014, 34 (44) 14697-14706; DOI: https://doi.org/10.1523/JNEUROSCI.2111-14.2014
Junyun He
Blood–Brain Barrier Group, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808
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Hung Hsuchou
Blood–Brain Barrier Group, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808
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Yi He
Blood–Brain Barrier Group, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808
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Abba J. Kastin
Blood–Brain Barrier Group, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808
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Yuping Wang
Blood–Brain Barrier Group, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808
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Weihong Pan
Blood–Brain Barrier Group, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808
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Abstract

The blood–brain barrier (BBB) is a large regulatory and exchange interface between the brain and peripheral circulation. We propose that changes of the BBB contribute to many pathophysiological processes in the brain of subjects with chronic sleep restriction (CSR). To achieve CSR that mimics a common pattern of human sleep loss, we quantified a new procedure of sleep disruption in mice by a week of consecutive sleep recording. We then tested the hypothesis that CSR compromises microvascular function. CSR not only diminished endothelial and inducible nitric oxide synthase, endothelin1, and glucose transporter expression in cerebral microvessels of the BBB, but it also decreased 2-deoxy-glucose uptake by the brain. The expression of several tight junction proteins also was decreased, whereas the level of cyclooxygenase-2 increased. This coincided with an increase of paracellular permeability of the BBB to the small tracers sodium fluorescein and biotin. CSR for 6 d was sufficient to impair BBB structure and function, although the increase of paracellular permeability returned to baseline after 24 h of recovery sleep. This merits attention not only in neuroscience research but also in public health policy and clinical practice.

  • BBB
  • glucose metabolism
  • sleep duration
  • sleep restriction
  • transport
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The Journal of Neuroscience: 34 (44)
Journal of Neuroscience
Vol. 34, Issue 44
29 Oct 2014
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Sleep Restriction Impairs Blood–Brain Barrier Function
Junyun He, Hung Hsuchou, Yi He, Abba J. Kastin, Yuping Wang, Weihong Pan
Journal of Neuroscience 29 October 2014, 34 (44) 14697-14706; DOI: 10.1523/JNEUROSCI.2111-14.2014

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Sleep Restriction Impairs Blood–Brain Barrier Function
Junyun He, Hung Hsuchou, Yi He, Abba J. Kastin, Yuping Wang, Weihong Pan
Journal of Neuroscience 29 October 2014, 34 (44) 14697-14706; DOI: 10.1523/JNEUROSCI.2111-14.2014
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Keywords

  • BBB
  • glucose metabolism
  • sleep duration
  • sleep restriction
  • transport

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