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Articles, Development/Plasticity/Repair

BDNF-Dependent Plasticity Induced by Peripheral Inflammation in the Primary Sensory and the Cingulate Cortex Triggers Cold Allodynia and Reveals a Major Role for Endogenous BDNF As a Tuner of the Affective Aspect of Pain

Karine Thibault, Wee Khang Lin, Armelle Rancillac, Marie Fan, Thibaut Snollaerts, Vallier Sordoillet, Michel Hamon, George M. Smith, Zsolt Lenkei and Sophie Pezet
Journal of Neuroscience 29 October 2014, 34 (44) 14739-14751; https://doi.org/10.1523/JNEUROSCI.0860-14.2014
Karine Thibault
1Brain Plasticity Unit, ESPCI-ParisTech, 75005 Paris, France,
2Centre National de la Recherche Scientifique, UMR 8249, 75794 Paris cedex 16, France,
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Wee Khang Lin
3Department of Pharmacology, University of Oxford, Oxford OX1 3QT, United Kingdom,
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Armelle Rancillac
1Brain Plasticity Unit, ESPCI-ParisTech, 75005 Paris, France,
2Centre National de la Recherche Scientifique, UMR 8249, 75794 Paris cedex 16, France,
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Marie Fan
1Brain Plasticity Unit, ESPCI-ParisTech, 75005 Paris, France,
2Centre National de la Recherche Scientifique, UMR 8249, 75794 Paris cedex 16, France,
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Thibaut Snollaerts
4Organisation Nucléaire et Oncogenèse, INSERM U993, Département de Biologie Cellulaire et Infection, Institut Pasteur, 75015 Paris, France,
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Vallier Sordoillet
1Brain Plasticity Unit, ESPCI-ParisTech, 75005 Paris, France,
2Centre National de la Recherche Scientifique, UMR 8249, 75794 Paris cedex 16, France,
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Michel Hamon
5UMR894 INSERM-CPN-UPMC, Faculté de Médecine Pierre et Marie Curie, Site Pitié-Salpêtrière, 75634 Paris cedex 13, France, and
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George M. Smith
6Shriners Hospitals Pediatric Research Center, Temple University, School of Medicine, Philadelphia, Pennsylvania 19140-5104
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Zsolt Lenkei
1Brain Plasticity Unit, ESPCI-ParisTech, 75005 Paris, France,
2Centre National de la Recherche Scientifique, UMR 8249, 75794 Paris cedex 16, France,
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Sophie Pezet
1Brain Plasticity Unit, ESPCI-ParisTech, 75005 Paris, France,
2Centre National de la Recherche Scientifique, UMR 8249, 75794 Paris cedex 16, France,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0860-14.2014
PubMed 
25355226
Published By 
Society for Neuroscience
History 
  • Received March 1, 2014
  • Revision received August 18, 2014
  • Accepted August 22, 2014
  • First published October 29, 2014.
  • Version of record published October 29, 2014.
Copyright & Usage 
Copyright © 2014 the authors 0270-6474/14/3414739-13$15.00/0

Author Information

  1. Karine Thibault1,2,
  2. Wee Khang Lin3,
  3. Armelle Rancillac1,2,
  4. Marie Fan1,2,
  5. Thibaut Snollaerts4,
  6. Vallier Sordoillet1,2,
  7. Michel Hamon5,
  8. George M. Smith6,
  9. Zsolt Lenkei1,2, and
  10. Sophie Pezet1,2
  1. 1Brain Plasticity Unit, ESPCI-ParisTech, 75005 Paris, France,
  2. 2Centre National de la Recherche Scientifique, UMR 8249, 75794 Paris cedex 16, France,
  3. 3Department of Pharmacology, University of Oxford, Oxford OX1 3QT, United Kingdom,
  4. 4Organisation Nucléaire et Oncogenèse, INSERM U993, Département de Biologie Cellulaire et Infection, Institut Pasteur, 75015 Paris, France,
  5. 5UMR894 INSERM-CPN-UPMC, Faculté de Médecine Pierre et Marie Curie, Site Pitié-Salpêtrière, 75634 Paris cedex 13, France, and
  6. 6Shriners Hospitals Pediatric Research Center, Temple University, School of Medicine, Philadelphia, Pennsylvania 19140-5104
  • K. Thibault's present address: Glia-Glia and Glia-Neuron Interactions in Neurophysiopathology Group, FR 3636, Paris Descartes University, 45 rue des Saints Pères 75006 Paris, France.

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Author contributions

  1. Author contributions: K.T., M.H., and S.P. designed research; K.T., W.K.L., A.R., M.F., T.S., V.S., and S.P. performed research; M.H. and G.M.S. contributed unpublished reagents/analytic tools; W.K.L., A.R., and S.P. analyzed data; K.T., Z.L., and S.P. wrote the paper.

  • K. Thibault's present address: Glia-Glia and Glia-Neuron Interactions in Neurophysiopathology Group, FR 3636, Paris Descartes University, 45 rue des Saints Pères 75006 Paris, France.

Disclosures

    • Received March 1, 2014.
    • Revision received August 18, 2014.
    • Accepted August 22, 2014.
  • This work was supported by the Centre National pour la Recherche Scientifique (CNRS), the Ecole Supérieure de Physique et Chimie Industrielles de la mairie de Paris, ParisTech, l'Institut UPSA de la Douleur (S.P.) and the Agence Nationale pour la Recherche (M.H.; ANR Contract “TrkBDNFarmod” 2012–2015). We thank Marcel Leopoldie for animal husbandry and Brandon Loveall of Improvence for English proofreading of the paper.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr Sophie Pezet, CNRS, ESPCI-ParisTech, 10 rue Vauquelin, 75005 Paris, France. sophie.pezet{at}espci.fr

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Jan 2018143618
Feb 2018144216
Mar 2018528527
Apr 2018206221
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Jun 2018156211
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Aug 2018273433
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Jan 201975710
Feb 201935712
Mar 2019183611
Apr 2019104913
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Mar 202072418
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Jun 202041111
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Aug 20205279
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Oct 20205156
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Total 2020105238116
Jan 2021111918
Feb 2021152017
Mar 202152613
Apr 202192112
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Jun 20218214
Jul 202172414
Aug 202162019
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Total 2022102233131
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Total 2024128268195
Jan 2025183613
Feb 2025303810
Mar 2025243413
Apr 2025161318
May 202522156
Jun 20255109
Total 202511514669
Total98125641192
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The Journal of Neuroscience: 34 (44)
Journal of Neuroscience
Vol. 34, Issue 44
29 Oct 2014
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BDNF-Dependent Plasticity Induced by Peripheral Inflammation in the Primary Sensory and the Cingulate Cortex Triggers Cold Allodynia and Reveals a Major Role for Endogenous BDNF As a Tuner of the Affective Aspect of Pain
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BDNF-Dependent Plasticity Induced by Peripheral Inflammation in the Primary Sensory and the Cingulate Cortex Triggers Cold Allodynia and Reveals a Major Role for Endogenous BDNF As a Tuner of the Affective Aspect of Pain
Karine Thibault, Wee Khang Lin, Armelle Rancillac, Marie Fan, Thibaut Snollaerts, Vallier Sordoillet, Michel Hamon, George M. Smith, Zsolt Lenkei, Sophie Pezet
Journal of Neuroscience 29 October 2014, 34 (44) 14739-14751; DOI: 10.1523/JNEUROSCI.0860-14.2014

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BDNF-Dependent Plasticity Induced by Peripheral Inflammation in the Primary Sensory and the Cingulate Cortex Triggers Cold Allodynia and Reveals a Major Role for Endogenous BDNF As a Tuner of the Affective Aspect of Pain
Karine Thibault, Wee Khang Lin, Armelle Rancillac, Marie Fan, Thibaut Snollaerts, Vallier Sordoillet, Michel Hamon, George M. Smith, Zsolt Lenkei, Sophie Pezet
Journal of Neuroscience 29 October 2014, 34 (44) 14739-14751; DOI: 10.1523/JNEUROSCI.0860-14.2014
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Keywords

  • hyperexcitability
  • neurotrophic factor
  • pain
  • viral vector

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