Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
  • EDITORIAL BOARD
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
  • SUBSCRIBE

User menu

  • Log in
  • My Cart

Search

  • Advanced search
Journal of Neuroscience
  • Log in
  • My Cart
Journal of Neuroscience

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
  • EDITORIAL BOARD
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
  • SUBSCRIBE
PreviousNext
Articles, Behavioral/Cognitive

A Designated Odor–Language Integration System in the Human Brain

Jonas K. Olofsson, Robert S. Hurley, Nicholas E. Bowman, Xiaojun Bao, M.-Marsel Mesulam and Jay A. Gottfried
Journal of Neuroscience 5 November 2014, 34 (45) 14864-14873; DOI: https://doi.org/10.1523/JNEUROSCI.2247-14.2014
Jonas K. Olofsson
1Department of Neurology and
3Psychology Department, Stockholm University, SE-10691 Stockholm, Sweden, and
4Swedish Collegium for Advanced Study, SE-75238 Uppsala, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robert S. Hurley
1Department of Neurology and
2Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Robert S. Hurley
Nicholas E. Bowman
1Department of Neurology and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xiaojun Bao
1Department of Neurology and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Xiaojun Bao
M.-Marsel Mesulam
1Department of Neurology and
2Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jay A. Gottfried
1Department of Neurology and
2Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Figures & Data

Figures

  • Figure 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 1.

    Stimuli and trial timings. A, Object cues used in the ERP experiment and their target words on nonmatching trials. On matching trials, targets were the names of each object. B, Trial timing in the ERP experiment. Olfactory or visual object cues were followed by written word targets, each with a duration of 1 s with a variable interstimulus interval. C, Object cues used in the fMRI experiment. On matching trials, the object was paired with its name, and on nonmatching trials, the object was paired (one time each) with the names of the other seven objects. D, Trial timing in the fMRI experiment. Olfactory or visual object cues were followed by auditory word targets, each with an approximate duration of 1 s and a fixed 4 s interstimulus interval.

  • Figure 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 2.

    Behavioral results in ERP and fMRI experiments. Cue modality (olfactory, visual) is labeled below each set of bars, and cue–target congruency is indicated by color. Significant comparisons (p < 0.05) are indicated by an asterisk. A, Accuracy (mean ±SE) during the ERP experiment. Lower accuracy on matching and related odor trials, compared with other trial types, showed that participants were more likely to incorrectly reject the odors' names, and to falsely accept the names of other odors from the same semantic category, compared with picture trials. B, Response times (mean ± SE) in the ERP experiment were slower on odor trials than on picture trials and on nonmatching (related and unrelated) versus matching trials. C, In the fMRI experiment, accuracy was also lower on odor-cued compared with picture-cued trials. D, RTs in the fMRI experiment were slower on odor than picture trials and on nonmatching versus matching trials.

  • Figure 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 3.

    Results from the ERP experiment. A, Grand-averaged ERP waveforms for the experimental conditions, from midline electrodes in anterior, central, and posterior regions of the scalp. The N400 was of significantly higher amplitude to nonmatching versus matching targets in all regions, except in anterior electrodes on olfactory-cued trials (top left). B, Electrode clusters used to examine significance in each scalp region. C, Scalp topography of the N400 effect (nonmatch minus match amplitude) for odor-cued trials (left), picture-cued trials (middle), and the difference between the two (right). N400 effects were relatively larger in posterior locations on odor-cued trials and relatively larger in anterior locations on picture-cued trials.

  • Figure 4.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 4.

    Anatomical mask of the dorsomedial ATL, corresponding to the area receiving direct projections from primary olfactory cortex. Left, boundaries of the ATL mask are shown superimposed on a single coronal T1-weighted section of the normalized, single-participant canonical MRI scan from SPM5 [y = 20 in MNI (Montreal Neurological Institute) coordinate space]. Right, The dashed yellow rectangle corresponds to the area of ATL displayed in serial coronal sections of the mask, spanning its full extent from y = 28 (anterior) to y = 10 (posterior). See Materials and Methods for more details.

  • Figure 5.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 5.

    Results from the fMRI experiment. A, Right OFC activation for nonmatching > matching odor-cued trials. B, Right OFC interaction effect of cue modality* target word congruency (mean ± SE; condition-specific error bars adjusted for between-participants differences), indicating that cross-adaptation for matching trials was present in odor-cued but not in picture-cued conditions. C, Left ATL activation for nonmatching > matching odor-cued conditions. D, Left ATL interaction effect of cue modality by target word congruency, indicating that cross-adaptation for matching trials was present in odor-cued but not in picture-cued trials.

  • Figure 6.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 6.

    Time-series profiles of fMRI signal change, aligned to trial onset and normalized across conditions at time 0. A, Time-course peaks in right OFC show little difference between match and nonmatch trials in response to the odor cue itself (∼5 s) but diverge in response to subsequent presentation of the target word (arrow, ∼7.5 s). Minimal reactivity is seen in association with the picture-cued trials. *p < 0.05, one-tailed, significant interaction between modality and congruency. B, In left ATL, odor cue-evoked fMRI response peaks (∼5 s) give way to cross-adapting profiles for matching versus nonmatching conditions (*; ∼7.5 s), whereas fMRI response profiles for picture-cued conditions remain relatively unreactive.

Back to top

In this issue

The Journal of Neuroscience: 34 (45)
Journal of Neuroscience
Vol. 34, Issue 45
5 Nov 2014
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Advertising (PDF)
  • Ed Board (PDF)
Email

Thank you for sharing this Journal of Neuroscience article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
A Designated Odor–Language Integration System in the Human Brain
(Your Name) has forwarded a page to you from Journal of Neuroscience
(Your Name) thought you would be interested in this article in Journal of Neuroscience.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
A Designated Odor–Language Integration System in the Human Brain
Jonas K. Olofsson, Robert S. Hurley, Nicholas E. Bowman, Xiaojun Bao, M.-Marsel Mesulam, Jay A. Gottfried
Journal of Neuroscience 5 November 2014, 34 (45) 14864-14873; DOI: 10.1523/JNEUROSCI.2247-14.2014

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Request Permissions
Share
A Designated Odor–Language Integration System in the Human Brain
Jonas K. Olofsson, Robert S. Hurley, Nicholas E. Bowman, Xiaojun Bao, M.-Marsel Mesulam, Jay A. Gottfried
Journal of Neuroscience 5 November 2014, 34 (45) 14864-14873; DOI: 10.1523/JNEUROSCI.2247-14.2014
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • evoked potentials
  • functional MRI
  • human olfactory system
  • language
  • lexical–semantic system
  • orbitofrontal cortex

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

Articles

  • Choice Behavior Guided by Learned, But Not Innate, Taste Aversion Recruits the Orbitofrontal Cortex
  • Maturation of Spontaneous Firing Properties after Hearing Onset in Rat Auditory Nerve Fibers: Spontaneous Rates, Refractoriness, and Interfiber Correlations
  • Insulin Treatment Prevents Neuroinflammation and Neuronal Injury with Restored Neurobehavioral Function in Models of HIV/AIDS Neurodegeneration
Show more Articles

Behavioral/Cognitive

  • Signatures of Electrical Stimulation Driven Network Interactions in the Human Limbic System
  • Dissociable Neural Mechanisms Underlie the Effects of Attention on Visual Appearance and Response Bias
  • Rhythmic Entrainment Echoes in Auditory Perception
Show more Behavioral/Cognitive
  • Home
  • Alerts
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Issue Archive
  • Collections

Information

  • For Authors
  • For Advertisers
  • For the Media
  • For Subscribers

About

  • About the Journal
  • Editorial Board
  • Privacy Policy
  • Contact
(JNeurosci logo)
(SfN logo)

Copyright © 2023 by the Society for Neuroscience.
JNeurosci Online ISSN: 1529-2401

The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.