Article Figures & Data
Figures
- Figure 1.
Running promoted OD plasticity in adult mouse V1. a–f, Optically recorded activity maps of the contralateral (contra) and ipsilateral (ipsi) eye in binocular V1 in mice raised in SCs with (c–f) or without (a, b) a RW, before (a, c, e) and after 7 d of MD (b, d, f). Maps in a–d are from acutely imaged mice. Maps in e and f are from a chronically imaged animal. Grayscale-coded response magnitude maps (numbers correspond to quantified V1 activation), two-dimensional OD maps, and the histogram of OD scores, including the average ODI, are illustrated. a, c, e, Without MD, activity patches evoked by stimulation of the contralateral eye were darker than those of the ipsilateral eye, the average ODI was positive, and warm colors prevailed in the OD maps, indicating contralateral dominance. b, d, f, While 7 d of MD did not induce OD plasticity in mice without a RW (b), it induced a strong OD shift toward the open eye in age-matched adult RW mice (d, f): after MD, the contralateral and ipsilateral eye activated V1 with nearly equal strength, colder colors appeared in the OD map, and the histogram of OD scores shifted to the left (blue arrows). Scale bar, 1 mm.
- Figure 2.
Quantification of V1 activation with and without a RW. a, c, Optically imaged ODIs of control animals and after MD in no-RW mice (gray), RW mice (blue), and 7 d RW mice (light blue). Symbols represent ODI values of individuals. Means are marked by horizontal lines. b, d, V1 activation elicited by stimulation of the contralateral (C) or ipsilateral (I) eye in control animals and after MD (black filled circle indicates MD eye). *p < 0.05, **p < 0.01, and ***p < 0.001.
- Figure 3.
Running had no effect on the optomotor reflex and its enhancement after MD. Visual acuity of the optomotor reflex plotted against days after MD. ***p < 0.001.
