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Articles, Neurobiology of Disease

Futsch/MAP1B mRNA Is a Translational Target of TDP-43 and Is Neuroprotective in a Drosophila Model of Amyotrophic Lateral Sclerosis

Alyssa N. Coyne, Bhavani Bagevalu Siddegowda, Patricia S. Estes, Jeffrey Johannesmeyer, Tina Kovalik, Scott G. Daniel, Antony Pearson, Robert Bowser and Daniela C. Zarnescu
Journal of Neuroscience 26 November 2014, 34 (48) 15962-15974; DOI: https://doi.org/10.1523/JNEUROSCI.2526-14.2014
Alyssa N. Coyne
1Departments of Molecular and Cellular Biology,
2Neuroscience, and
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Bhavani Bagevalu Siddegowda
1Departments of Molecular and Cellular Biology,
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Patricia S. Estes
1Departments of Molecular and Cellular Biology,
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Jeffrey Johannesmeyer
1Departments of Molecular and Cellular Biology,
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Tina Kovalik
4Divisions of Neurobiology and Neurology, Barrow Neurological Institute, Phoenix, Arizona 85013
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Scott G. Daniel
1Departments of Molecular and Cellular Biology,
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Antony Pearson
1Departments of Molecular and Cellular Biology,
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Robert Bowser
4Divisions of Neurobiology and Neurology, Barrow Neurological Institute, Phoenix, Arizona 85013
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Daniela C. Zarnescu
1Departments of Molecular and Cellular Biology,
2Neuroscience, and
3Neurology, University of Arizona, Tucson, Arizona 85721, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2526-14.2014
PubMed 
25429138
Published By 
Society for Neuroscience
History 
  • Received June 20, 2014
  • Revision received October 8, 2014
  • Accepted October 14, 2014
  • First published November 26, 2014.
  • Version of record published November 26, 2014.
Copyright & Usage 
Copyright © 2014 the authors 0270-6474/14/3415962-13$15.00/0

Author Information

  1. Alyssa N. Coyne1,2,
  2. Bhavani Bagevalu Siddegowda1,
  3. Patricia S. Estes1,
  4. Jeffrey Johannesmeyer1,
  5. Tina Kovalik4,
  6. Scott G. Daniel1,
  7. Antony Pearson1,
  8. Robert Bowser4, and
  9. Daniela C. Zarnescu1,2,3
  1. 1Departments of Molecular and Cellular Biology,
  2. 2Neuroscience, and
  3. 3Neurology, University of Arizona, Tucson, Arizona 85721, and
  4. 4Divisions of Neurobiology and Neurology, Barrow Neurological Institute, Phoenix, Arizona 85013
View Full Text

Author contributions

  1. Author contributions: A.N.C., B.B.S., P.S.E., R.B., and D.C.Z. designed research; A.N.C., B.B.S., P.S.E., J.J., T.K., and A.P. performed research; S.G.D. and A.P. contributed unpublished reagents/analytic tools; A.N.C., P.S.E., R.B., and D.C.Z. analyzed data; A.N.C., R.B., and D.C.Z. wrote the paper.

Disclosures

    • Received June 20, 2014.
    • Revision received October 8, 2014.
    • Accepted October 14, 2014.
  • This work was supported by NIH Grants NS078429 (D.C.Z.) and NS061867 (R.B.) and MDA Grant 255293 (D.C.Z.). Additional funds were provided by the Himelic Family Foundation, the Neuroscience Graduate Interdisciplinary Program at the University of Arizona (A.N.C.), and the Beckman Foundation (A.P.). The 22C10 monoclonal antibody was obtained from the Developmental Studies Hybridoma Bank, developed under the auspices of the NICHD and maintained by the Department of Biology, The University of Iowa (Iowa City, IA). We thank members of the Zarnescu laboratory and Ross Buchan for helpful suggestions on this manuscript.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr. Daniela C. Zarnescu at the above address. zarnescu{at}email.arizona.edu

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Nov 2014121752101
Dec 2014791145149
Total 20142008197250
Jan 20154487454
Feb 20151883530
Mar 20151004021
Apr 20151145329
May 2015852926
Jun 2015567036
Jul 2015553716
Aug 2015302617
Sep 2015485121
Oct 2015503726
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Dec 2015304144
Total 20151250535334
Jan 2016465228
Feb 2016305112
Mar 2016483641
Apr 2016324621
May 2016293825
Jun 2016213122
Jul 2016212912
Aug 2016362716
Sep 2016292213
Oct 2016202919
Nov 2016273419
Dec 2016142113
Total 2016353416241
Jan 2017136214
Feb 2017133118
Mar 2017115520
Apr 2017113725
May 201793426
Jun 2017133921
Jul 2017244318
Aug 201783431
Sep 2017121912
Oct 2017202529
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Dec 201728368
Total 2017184461238
Jan 2018204425
Feb 20189319
Mar 2018153713
Apr 201895012
May 2018107711
Jun 2018612411
Jul 2018178913
Aug 2018107012
Sep 201811587
Oct 201877513
Nov 201812888
Dec 2018115111
Total 2018137794145
Jan 201973710
Feb 201983911
Mar 201962810
Apr 2019201814
May 201915418
Jun 201914269
Jul 201942221
Aug 201922411
Sep 20197449
Oct 20191710518
Nov 201953430
Dec 20195328
Total 2019110450159
Jan 202083115
Feb 2020512813
Mar 2020420712
Apr 20201021425
May 20201112722
Jun 20206987
Jul 202048210
Aug 202078012
Sep 2020158416
Oct 202065818
Nov 202054712
Dec 202053012
Total 2020861186174
Jan 2021123814
Feb 202113124
Mar 202143311
Apr 20216378
May 2021104318
Jun 202153622
Jul 202174318
Aug 202144214
Sep 2021124617
Oct 2021152922
Nov 2021154128
Dec 20215235
Total 202196442201
Jan 202283117
Feb 202211427
Mar 2022134713
Apr 202274312
May 202241017
Total 20224317366
Total426746541808
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The Journal of Neuroscience: 34 (48)
Journal of Neuroscience
Vol. 34, Issue 48
26 Nov 2014
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Futsch/MAP1B mRNA Is a Translational Target of TDP-43 and Is Neuroprotective in a Drosophila Model of Amyotrophic Lateral Sclerosis
Alyssa N. Coyne, Bhavani Bagevalu Siddegowda, Patricia S. Estes, Jeffrey Johannesmeyer, Tina Kovalik, Scott G. Daniel, Antony Pearson, Robert Bowser, Daniela C. Zarnescu
Journal of Neuroscience 26 November 2014, 34 (48) 15962-15974; DOI: 10.1523/JNEUROSCI.2526-14.2014

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Futsch/MAP1B mRNA Is a Translational Target of TDP-43 and Is Neuroprotective in a Drosophila Model of Amyotrophic Lateral Sclerosis
Alyssa N. Coyne, Bhavani Bagevalu Siddegowda, Patricia S. Estes, Jeffrey Johannesmeyer, Tina Kovalik, Scott G. Daniel, Antony Pearson, Robert Bowser, Daniela C. Zarnescu
Journal of Neuroscience 26 November 2014, 34 (48) 15962-15974; DOI: 10.1523/JNEUROSCI.2526-14.2014
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Keywords

  • microtubule stability
  • neuromuscular junction
  • RNA metabolism

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