Article Information
- Received July 22, 2014
- Revision received October 10, 2014
- Accepted October 16, 2014
- First published December 3, 2014.
- Version of record published December 3, 2014.
Author Information
- Jeffrey J. Iliff1,2,3,
- Michael J. Chen1,
- Benjamin A. Plog1,
- Douglas M. Zeppenfeld2,3,
- Melissa Soltero2,
- Lijun Yang1,
- Itender Singh1,
- Rashid Deane1, and
- Maiken Nedergaard1
- 1Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642 and
- 2Department of Anesthesiology and Peri-Operative Medicine, and
- 3Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon 97239
Author contributions
Author contributions: J.J.I., L.Y., I.S., and R.D. designed research; J.J.I., M.J.C., B.A.P., D.M.Z., M.S., and M.N. performed research; J.J.I., M.J.C., B.A.P., D.M.Z., M.S., L.Y., I.S., R.D., and M.N. analyzed data; J.J.I. wrote the paper.
Disclosures
- Received July 22, 2014.
- Revision received October 10, 2014.
- Accepted October 16, 2014.
This study was supported by National Institutes of Health–National Institute of Neurological Disorders and Stroke (NS078167 and NS078304 to M.N. and NS073373 to J.J.I.) and the American Heart Association (12SDG11820014 to J.J.I.). We thank Dr. Marjorie Grafe, Xiao Jing Nie, and Dr. Lijunan Liu of the Oregon Health & Science University Department of Anesthesiology and Peri-Operative Medicine Histology Core for expert technical assistance performing histological studies.
The authors declare no competing financial interests.
- Correspondence should be addressed to Jeffrey J. Iliff, PhD, Department of Anesthesiology and Peri-Operative Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Mail Code HRC5N, Portland, OR 97239. iliffj{at}ohsu.edu