Article Information
- Received April 11, 2014
- Revision received October 9, 2014
- Accepted October 23, 2014
- First published December 3, 2014.
- Version of record published December 3, 2014.
Author Information
- Wanpeng Cui1,
- Hiroaki Mizukami2,
- Michiko Yanagisawa1,
- Tomomi Aida1,
- Masatoshi Nomura3,
- Yoshikazu Isomura4,
- Ryoichi Takayanagi3,
- Keiya Ozawa2,
- Kohichi Tanaka1,5,6, and
- Hidenori Aizawa1
- 1Laboratory of Molecular Neuroscience, Medical Research Institute and
- 6Center for Brain Integration Research, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510 Japan,
- 2Division of Genetic Therapeutics, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, 329-0498 Japan,
- 3Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan,
- 4Tamagawa University Brain Science Institute, 6-1-1 Tamagawa Gakuen, Machida, Tokyo, 194-8610 Japan, and
- 5Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Sanbancho Building 5, Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan
Author contributions
Author contributions: K.T. and H.A. designed research; W.C., H.M., M.Y., T.A., and H.A. performed research; M.N., Y.I., R.T., and K.O. contributed unpublished reagents/analytic tools; W.C. and H.A. analyzed data; K.T. and H.A. wrote the paper.
Disclosures
- Received April 11, 2014.
- Revision received October 9, 2014.
- Accepted October 23, 2014.
This work was supported by the Mitsui Life Social Welfare Foundation, the Takeda Science Foundation, the Naito Foundation, the Uehara Memorial Foundation, the Suzuken Memorial Foundation, the KANAE foundation for the promotion of medical sciences, the Inamori Foundation, and the Brain Science Foundation; by a Grant-in-Aid for Young Scientists (B) (KAKENHI24700350), a Grant-in-Aid for Scientific Research on Innovative Areas (KAKENHI26112010), and a Grant-in-Aid for Scientific Research (C) (KAKENHI26430008) from the Ministry of Education, Culture, Sports, Science and Technology to H.A.; and by the Core Research for Evolutional Science and Technology of Japan Science and Technology Agency to K.T. A portion of this study is the result of “Understanding of molecular and environmental bases for brain health” performed under the Strategic Research Program for Brain Sciences by Ministry of Education, Culture, Sports, Science and Technology. We thank Masahiko Watanabe for the anti-GLT-1 and anti-GLAST antibodies; Jinghui Dong and Douglas A. Coulter for pZac-Gfa104-EGFP plasmid DNA; Hitoshi Okamoto for discussion; and Harumi Ishikubo and Masako Hidaka for technical support.
The authors declare no competing financial interests.
- Correspondence should be addressed to either Dr. Hidenori Aizawa or Dr. Kohichi Tanaka, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510 Japan, haizawa.aud{at}mri.tmd.ac.jp or tanaka.aud{at}mri.tmd.ac.jp