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PreviousNext
Cover ArticleArticles, Cellular/Molecular

Synaptic Strength Is Bidirectionally Controlled by Opposing Activity-Dependent Regulation of Nedd4-1 and USP8

Samantha L. Scudder, Marisa S. Goo, Anna E. Cartier, Alice Molteni, Lindsay A. Schwarz, Rebecca Wright and Gentry N. Patrick
Journal of Neuroscience 10 December 2014, 34 (50) 16637-16649; DOI: https://doi.org/10.1523/JNEUROSCI.2452-14.2014
Samantha L. Scudder
1University of California San Diego, Section of Neurobiology, Division of Biological Sciences, La Jolla, California 92093,
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Marisa S. Goo
1University of California San Diego, Section of Neurobiology, Division of Biological Sciences, La Jolla, California 92093,
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  • ORCID record for Marisa S. Goo
Anna E. Cartier
2ICB International, La Jolla, California 92037,
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Alice Molteni
1University of California San Diego, Section of Neurobiology, Division of Biological Sciences, La Jolla, California 92093,
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Lindsay A. Schwarz
3Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, and
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Rebecca Wright
4The Salk Institute for Biological Studies, La Jolla, California 92037
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Gentry N. Patrick
1University of California San Diego, Section of Neurobiology, Division of Biological Sciences, La Jolla, California 92093,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2452-14.2014
PubMed 
25505317
Published By 
Society for Neuroscience
History 
  • Received June 15, 2014
  • Revision received October 3, 2014
  • Accepted October 27, 2014
  • First published December 10, 2014.
  • Version of record published December 10, 2014.
Copyright & Usage 
Copyright © 2014 the authors 0270-6474/14/3416637-13$15.00/0

Author Information

  1. Samantha L. Scudder1,
  2. Marisa S. Goo1,
  3. Anna E. Cartier2,
  4. Alice Molteni1,
  5. Lindsay A. Schwarz3,
  6. Rebecca Wright4, and
  7. Gentry N. Patrick1
  1. 1University of California San Diego, Section of Neurobiology, Division of Biological Sciences, La Jolla, California 92093,
  2. 2ICB International, La Jolla, California 92037,
  3. 3Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, and
  4. 4The Salk Institute for Biological Studies, La Jolla, California 92037
View Full Text

Author contributions

  1. Author contributions: S.L.S., M.S.G., A.E.C., A.M., L.A.S., and G.N.P. designed research; S.L.S., M.S.G., A.E.C., A.M., R.W., and G.N.P. performed research; S.L.S., M.S.G., A.M., and G.N.P. analyzed data; S.L.S., M.S.G., and G.N.P. wrote the paper.

Disclosures

    • Received June 15, 2014.
    • Revision received October 3, 2014.
    • Accepted October 27, 2014.
  • This work was supported by the National Science Foundation (Graduate Research Fellowships to S.L.S. and M.S.G.), the National Institutes of Health (Grant NS060847 to G.N.P., Training Grant T32 AG00216 to S.L.S.), and the Center for Systems Biology (Grant P50-GMO85764). We thank R. Malinow, B. Bloodgood, and members of the Patrick laboratory for helpful discussion and Lara Dozier for technical assistance.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Gentry N. Patrick, Section of Neurobiology, Division of Biological Sciences, 9500 Gilman Drive, La Jolla, CA 92093-0347. gpatrick{at}ucsd.edu

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Jan 20189184
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The Journal of Neuroscience: 34 (50)
Journal of Neuroscience
Vol. 34, Issue 50
10 Dec 2014
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Synaptic Strength Is Bidirectionally Controlled by Opposing Activity-Dependent Regulation of Nedd4-1 and USP8
Samantha L. Scudder, Marisa S. Goo, Anna E. Cartier, Alice Molteni, Lindsay A. Schwarz, Rebecca Wright, Gentry N. Patrick
Journal of Neuroscience 10 December 2014, 34 (50) 16637-16649; DOI: 10.1523/JNEUROSCI.2452-14.2014

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Synaptic Strength Is Bidirectionally Controlled by Opposing Activity-Dependent Regulation of Nedd4-1 and USP8
Samantha L. Scudder, Marisa S. Goo, Anna E. Cartier, Alice Molteni, Lindsay A. Schwarz, Rebecca Wright, Gentry N. Patrick
Journal of Neuroscience 10 December 2014, 34 (50) 16637-16649; DOI: 10.1523/JNEUROSCI.2452-14.2014
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Keywords

  • AMPA receptors
  • deubiquitination
  • E3 ubiquitin ligase
  • endocytosis
  • lysosome
  • ubiquitin

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