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Featured ArticleArticles, Neurobiology of Disease

Obesity Elicits Interleukin 1-Mediated Deficits in Hippocampal Synaptic Plasticity

Joanna R. Erion, Marlena Wosiski-Kuhn, Aditi Dey, Shuai Hao, Catherine L. Davis, Norman K. Pollock and Alexis M. Stranahan
Journal of Neuroscience 12 February 2014, 34 (7) 2618-2631; DOI: https://doi.org/10.1523/JNEUROSCI.4200-13.2014
Joanna R. Erion
1Department of Physiology and
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Marlena Wosiski-Kuhn
1Department of Physiology and
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Aditi Dey
1Department of Physiology and
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Shuai Hao
1Department of Physiology and
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Catherine L. Davis
1Department of Physiology and
2Georgia Prevention Institute, Medical College of Georgia, Georgia Regents University, Augusta, Georgia 30912
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Norman K. Pollock
2Georgia Prevention Institute, Medical College of Georgia, Georgia Regents University, Augusta, Georgia 30912
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Alexis M. Stranahan
1Department of Physiology and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4200-13.2014
PubMed 
24523551
Published By 
Society for Neuroscience
History 
  • Received October 1, 2013
  • Revision received January 2, 2014
  • Accepted January 8, 2014
  • First published February 12, 2014.
  • Version of record published February 12, 2014.
Copyright & Usage 
Copyright © 2014 the authors 0270-6474/14/342618-14$15.00/0

Author Information

  1. Joanna R. Erion1,*,
  2. Marlena Wosiski-Kuhn1,*,
  3. Aditi Dey1,
  4. Shuai Hao1,
  5. Catherine L. Davis1,2,
  6. Norman K. Pollock2, and
  7. Alexis M. Stranahan1
  1. 1Department of Physiology and
  2. 2Georgia Prevention Institute, Medical College of Georgia, Georgia Regents University, Augusta, Georgia 30912
View Full Text

Author contributions

  1. Author contributions: J.R.E., M.W.-K., C.L.D., N.K.P., and A.M.S. designed research; J.R.E., M.W.-K., A.D., S.H., C.L.D., N.K.P., and A.M.S. performed research; J.R.E., M.W.-K., A.D., S.H., C.L.D., N.K.P., and A.M.S. analyzed data; J.R.E., M.W.-K., A.D., S.H., C.L.D., N.K.P., and A.M.S. wrote the paper.

  2. ↵*J.R.E. and M.W.-K. contributed equally to this work.

Disclosures

    • Received October 1, 2013.
    • Revision received January 2, 2014.
    • Accepted January 8, 2014.
  • This project was supported by an intramural grant from the Medical College of Georgia (C.L.D., N.K.P.) and Grant 1K01DK100616-01 from the National Institute of Diabetes, Digestive, and Kidney Diseases of the NIH (A.M.S.). We are grateful to Dr. Matthew Frank and Dr. Steven Maier for initial training and valuable advice on the microglia isolation protocol, Dr. Ruth Harris for advice on lipectomy and fat transplantation, and Dr. Lynnette McCluskey for critical reading of this manuscript.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Alexis M. Stranahan, Medical College of Georgia, Georgia Regents University, Physiology Department, 1120 15th Street, Room CA3145, Augusta, GA 30912. astranahan{at}gru.edu

Online Impact

 

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Jan 2018157322
Feb 2018105518
Mar 2018147043
Apr 201876316
May 201887830
Jun 201875915
Jul 201884913
Aug 201863413
Sep 201874415
Oct 2018105932
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Total 2018109667239
Jan 20193529530
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Mar 2019244730
Apr 2019328625
May 2019444424
Jun 2019133919
Jul 2019193414
Aug 2019153017
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Mar 2020106922
May 2020324438
Jun 2020102921
Jul 2020142215
Aug 202082619
Sep 202011208
Oct 2020113812
Nov 2020164831
Dec 2020184726
Total 2020164422240
Jan 2021123221
Feb 202193720
Mar 2021283836
Apr 2021163919
May 2021264320
Jun 2021223322
Jul 2021264042
Aug 202113512712
Sep 2021123825
Oct 2021124636
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Dec 2021184523
Total 2021320549305
Jan 2022193019
Feb 202293513
Mar 2022125735
Apr 202253519
May 202272924
Jun 202283723
Jul 2022134019
Aug 2022243826
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Oct 2022175430
Nov 20222910
Dec 202233015
Total 2022152433256
Jan 2023127218
Feb 2023114021
Mar 2023174722
Apr 2023134010
May 202373623
Jun 202372411
Jul 2023132920
Aug 2023152513
Sep 202347135
Oct 2023130
Total 2023100387173
Total110133271439
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The Journal of Neuroscience: 34 (7)
Journal of Neuroscience
Vol. 34, Issue 7
12 Feb 2014
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Obesity Elicits Interleukin 1-Mediated Deficits in Hippocampal Synaptic Plasticity
Joanna R. Erion, Marlena Wosiski-Kuhn, Aditi Dey, Shuai Hao, Catherine L. Davis, Norman K. Pollock, Alexis M. Stranahan
Journal of Neuroscience 12 February 2014, 34 (7) 2618-2631; DOI: 10.1523/JNEUROSCI.4200-13.2014

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Obesity Elicits Interleukin 1-Mediated Deficits in Hippocampal Synaptic Plasticity
Joanna R. Erion, Marlena Wosiski-Kuhn, Aditi Dey, Shuai Hao, Catherine L. Davis, Norman K. Pollock, Alexis M. Stranahan
Journal of Neuroscience 12 February 2014, 34 (7) 2618-2631; DOI: 10.1523/JNEUROSCI.4200-13.2014
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Keywords

  • diabetes
  • hippocampus
  • inflammation
  • microglia
  • obesity
  • synapse

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