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Articles, Systems/Circuits

Cortical and Thalamic Excitation Mediate the Multiphasic Responses of Striatal Cholinergic Interneurons to Motivationally Salient Stimuli

Natalie M. Doig, Peter J. Magill, Paul Apicella, J. Paul Bolam and Andrew Sharott
Journal of Neuroscience 19 February 2014, 34 (8) 3101-3117; https://doi.org/10.1523/JNEUROSCI.4627-13.2014
Natalie M. Doig
1Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Oxford OX1 3TH, United Kingdom; and
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Peter J. Magill
1Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Oxford OX1 3TH, United Kingdom; and
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Paul Apicella
2Institut de Neurosciences de la Timone, Centre National de la Recherche Scientifique-Aix-Marseille Université, 13005 Marseille, France
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J. Paul Bolam
1Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Oxford OX1 3TH, United Kingdom; and
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Andrew Sharott
1Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Oxford OX1 3TH, United Kingdom; and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4627-13.2014
PubMed 
24553950
Published By 
Society for Neuroscience
History 
  • Received October 28, 2013
  • Revision received January 17, 2014
  • Accepted January 23, 2014
  • First published February 19, 2014.
  • Version of record published February 19, 2014.
Copyright & Usage 
Copyright © 2014 the authors 0270-6474/14/343101-17$15.00/0

Author Information

  1. Natalie M. Doig1,
  2. Peter J. Magill1,
  3. Paul Apicella2,
  4. J. Paul Bolam1, and
  5. Andrew Sharott1
  1. 1Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Oxford OX1 3TH, United Kingdom; and
  2. 2Institut de Neurosciences de la Timone, Centre National de la Recherche Scientifique-Aix-Marseille Université, 13005 Marseille, France
View Full Text

Author contributions

  1. Author contributions: N.M.D., P.J.M., J.P.B., and A.S. designed research; N.M.D., P.A., and A.S. performed research; A.S. analyzed data; N.M.D. and A.S. wrote the paper.

Disclosures

    • Received October 28, 2013.
    • Revision received January 17, 2014.
    • Accepted January 23, 2014.
  • This work was supported by the Medical Research Council UK (Grants U138197109 and U138164490), Parkinson's UK (Grant G-0806), a Marie Curie European Re-integration Grant (SNAP-PD) awarded by the European Union, and an International Joint Project Grant (Grant JP090457) awarded by The Royal Society. N.M.D. was in receipt of a Medical Research Council studentship. We thank J. Morgan for the generous gift of antibodies against Cerebellin-1; G. Hazell, B. Micklem, L. Norman, K. Whitworth, and C. Johnson for technical support; I. Huerta-Ocampo and K. Nakamura for advice and assistance with immunohistochemistry; F. Vinciati for contributing to electrophysiological recordings; members of the Apicella laboratory for help with TAN data collection; and P. Henny for assistance with EM analysis and helpful comments on the manuscript.

  • Correspondence should be addressed to Andrew Sharott, MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, Mansfield Road, Oxford OX1 3TH, United Kingdom. andrew.sharott{at}pharm.ox.ac.uk

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The Journal of Neuroscience: 34 (8)
Journal of Neuroscience
Vol. 34, Issue 8
19 Feb 2014
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Cortical and Thalamic Excitation Mediate the Multiphasic Responses of Striatal Cholinergic Interneurons to Motivationally Salient Stimuli
Natalie M. Doig, Peter J. Magill, Paul Apicella, J. Paul Bolam, Andrew Sharott
Journal of Neuroscience 19 February 2014, 34 (8) 3101-3117; DOI: 10.1523/JNEUROSCI.4627-13.2014

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Cortical and Thalamic Excitation Mediate the Multiphasic Responses of Striatal Cholinergic Interneurons to Motivationally Salient Stimuli
Natalie M. Doig, Peter J. Magill, Paul Apicella, J. Paul Bolam, Andrew Sharott
Journal of Neuroscience 19 February 2014, 34 (8) 3101-3117; DOI: 10.1523/JNEUROSCI.4627-13.2014
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Keywords

  • basal ganglia
  • corticostriatal
  • parafascicular nucleus
  • thalamostriatal
  • tonically active neuron

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