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Articles, Systems/Circuits

Circuit Formation and Function in the Olfactory Bulb of Mice with Reduced Spontaneous Afferent Activity

Paolo Lorenzon, Nelly Redolfi, Michael J. Podolsky, Ilaria Zamparo, Sira Angela Franchi, Gianluca Pietra, Anna Boccaccio, Anna Menini, Venkatesh N. Murthy and Claudia Lodovichi
Journal of Neuroscience 7 January 2015, 35 (1) 146-160; DOI: https://doi.org/10.1523/JNEUROSCI.0613-14.2015
Paolo Lorenzon
1Venetian Institute of Molecular Medicine (VIMM), 35129 Padua, Italy,
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Nelly Redolfi
1Venetian Institute of Molecular Medicine (VIMM), 35129 Padua, Italy,
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Michael J. Podolsky
2Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114,
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Ilaria Zamparo
1Venetian Institute of Molecular Medicine (VIMM), 35129 Padua, Italy,
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Sira Angela Franchi
1Venetian Institute of Molecular Medicine (VIMM), 35129 Padua, Italy,
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Gianluca Pietra
3Neurobiology Group, SISSA, International School for Advanced Studies, 34136 Trieste, Italy,
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Anna Boccaccio
4Biophysics Institute, CNR, 16149 Genova, Italy,
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Anna Menini
3Neurobiology Group, SISSA, International School for Advanced Studies, 34136 Trieste, Italy,
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Venkatesh N. Murthy
5Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, and
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Claudia Lodovichi
1Venetian Institute of Molecular Medicine (VIMM), 35129 Padua, Italy,
6Neuroscience Institute, CNR, 35129 Padua, Italy
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Abstract

The type of neuronal activity required for circuit development is a matter of significant debate. We addressed this issue by analyzing the topographic organization of the olfactory bulb in transgenic mice engineered to have very little afferent spontaneous activity due to the overexpression of the inwardly rectifying potassium channel Kir2.1 in the olfactory sensory neurons (Kir2.1 mice). In these conditions, the topography of the olfactory bulb was unrefined. Odor-evoked responses were readily recorded in glomeruli with reduced spontaneous afferent activity, although the functional maps were coarser than in controls and contributed to altered olfactory discrimination behavior. In addition, overexpression of Kir2.1 in adults induced a regression of the already refined connectivity to an immature (i.e., coarser) status. Our data suggest that spontaneous activity plays a critical role not only in the development but also in the maintenance of the topography of the olfactory bulb and in sensory information processing.

  • behavior
  • functional imaging
  • olfactory bulb
  • olfactory system
  • sensory map
  • topography
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The Journal of Neuroscience: 35 (1)
Journal of Neuroscience
Vol. 35, Issue 1
7 Jan 2015
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Circuit Formation and Function in the Olfactory Bulb of Mice with Reduced Spontaneous Afferent Activity
Paolo Lorenzon, Nelly Redolfi, Michael J. Podolsky, Ilaria Zamparo, Sira Angela Franchi, Gianluca Pietra, Anna Boccaccio, Anna Menini, Venkatesh N. Murthy, Claudia Lodovichi
Journal of Neuroscience 7 January 2015, 35 (1) 146-160; DOI: 10.1523/JNEUROSCI.0613-14.2015

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Circuit Formation and Function in the Olfactory Bulb of Mice with Reduced Spontaneous Afferent Activity
Paolo Lorenzon, Nelly Redolfi, Michael J. Podolsky, Ilaria Zamparo, Sira Angela Franchi, Gianluca Pietra, Anna Boccaccio, Anna Menini, Venkatesh N. Murthy, Claudia Lodovichi
Journal of Neuroscience 7 January 2015, 35 (1) 146-160; DOI: 10.1523/JNEUROSCI.0613-14.2015
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Keywords

  • behavior
  • functional imaging
  • olfactory bulb
  • olfactory system
  • sensory map
  • topography

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