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Articles, Behavioral/Cognitive

Removal of Perineuronal Nets in the Medial Prefrontal Cortex Impairs the Acquisition and Reconsolidation of a Cocaine-Induced Conditioned Place Preference Memory

Megan Slaker, Lynn Churchill, Ryan P. Todd, Jordan M. Blacktop, Damian G. Zuloaga, Jacob Raber, Rebecca A. Darling, Travis E. Brown and Barbara A. Sorg
Journal of Neuroscience 11 March 2015, 35 (10) 4190-4202; DOI: https://doi.org/10.1523/JNEUROSCI.3592-14.2015
Megan Slaker
1Department of Integrative Physiology and Neuroscience, Washington State University, Vancouver, Washington 98686,
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Lynn Churchill
2Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington 99164,
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Ryan P. Todd
1Department of Integrative Physiology and Neuroscience, Washington State University, Vancouver, Washington 98686,
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Jordan M. Blacktop
1Department of Integrative Physiology and Neuroscience, Washington State University, Vancouver, Washington 98686,
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Damian G. Zuloaga
3Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239,
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Jacob Raber
3Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239,
4Departments of Neurology and Radiation Medicine, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon 97239, and
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Rebecca A. Darling
5School of Pharmacy and Department of Neuroscience, University of Wyoming, Laramie, Wyoming 82071
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Travis E. Brown
5School of Pharmacy and Department of Neuroscience, University of Wyoming, Laramie, Wyoming 82071
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Barbara A. Sorg
1Department of Integrative Physiology and Neuroscience, Washington State University, Vancouver, Washington 98686,
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This article has a correction. Please see:

  • Correction: Slaker et al., Removal of Perineuronal Nets in the Medial Prefrontal Cortex Impairs the Acquisition and Reconsolidation of a Cocaine-Induced Conditioned Place Preference Memory - May 27, 2015

Abstract

Pyramidal neurons in the medial prefrontal cortex (mPFC) critically contribute to cocaine-seeking behavior in humans and rodents. Activity of these neurons is significantly modulated by GABAergic, parvalbumin-containing, fast-spiking interneurons, the majority of which are enveloped by specialized structures of extracellular matrix called perineuronal nets (PNNs), which are integral to the maintenance of many types of plasticity. Using a conditioned place preference (CPP) procedure, we found that removal of PNNs primarily from the prelimbic region of the mPFC of adult, male, Sprague Dawley rats impaired the acquisition and reconsolidation of a cocaine-induced CPP memory. This impairment was accompanied by a decrease in the number of c-Fos-positive cells surrounded by PNNs. Following removal of PNNs, the frequency of inhibitory currents in mPFC pyramidal neurons was decreased; but following cocaine-induced CPP, both frequency and amplitude of inhibitory currents were decreased. Our findings suggest that cocaine-induced plasticity is impaired by removal of prelimbic mPFC PNNs and that PNNs may be a therapeutic target for disruption of cocaine CPP memories.

  • cocaine
  • conditioned place preference
  • memory
  • perineuronal net
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The Journal of Neuroscience: 35 (10)
Journal of Neuroscience
Vol. 35, Issue 10
11 Mar 2015
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Removal of Perineuronal Nets in the Medial Prefrontal Cortex Impairs the Acquisition and Reconsolidation of a Cocaine-Induced Conditioned Place Preference Memory
Megan Slaker, Lynn Churchill, Ryan P. Todd, Jordan M. Blacktop, Damian G. Zuloaga, Jacob Raber, Rebecca A. Darling, Travis E. Brown, Barbara A. Sorg
Journal of Neuroscience 11 March 2015, 35 (10) 4190-4202; DOI: 10.1523/JNEUROSCI.3592-14.2015

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Removal of Perineuronal Nets in the Medial Prefrontal Cortex Impairs the Acquisition and Reconsolidation of a Cocaine-Induced Conditioned Place Preference Memory
Megan Slaker, Lynn Churchill, Ryan P. Todd, Jordan M. Blacktop, Damian G. Zuloaga, Jacob Raber, Rebecca A. Darling, Travis E. Brown, Barbara A. Sorg
Journal of Neuroscience 11 March 2015, 35 (10) 4190-4202; DOI: 10.1523/JNEUROSCI.3592-14.2015
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Keywords

  • cocaine
  • conditioned place preference
  • memory
  • perineuronal net

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