Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
  • EDITORIAL BOARD
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
  • SUBSCRIBE

User menu

  • Log in
  • My Cart

Search

  • Advanced search
Journal of Neuroscience
  • Log in
  • My Cart
Journal of Neuroscience

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
  • EDITORIAL BOARD
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
  • SUBSCRIBE
PreviousNext
Featured ArticleArticles, Cellular/Molecular

Orexin–Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine

Gemma Navarro, César Quiroz, David Moreno-Delgado, Adam Sierakowiak, Kimberly McDowell, Estefanía Moreno, William Rea, Ning-Sheng Cai, David Aguinaga, Lesley A. Howell, Felix Hausch, Antonio Cortés, Josefa Mallol, Vicent Casadó, Carme Lluís, Enric I. Canela, Sergi Ferré and Peter J. McCormick
Journal of Neuroscience 29 April 2015, 35 (17) 6639-6653; DOI: https://doi.org/10.1523/JNEUROSCI.4364-14.2015
Gemma Navarro
1Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Center for Biomedical Research in Neurodegenerative Diseases Network and Institute of Biomedicine of the University of Barcelona, 08028 Barcelona, Spain,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
César Quiroz
2Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Moreno-Delgado
1Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Center for Biomedical Research in Neurodegenerative Diseases Network and Institute of Biomedicine of the University of Barcelona, 08028 Barcelona, Spain,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for David Moreno-Delgado
Adam Sierakowiak
2Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kimberly McDowell
2Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Estefanía Moreno
1Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Center for Biomedical Research in Neurodegenerative Diseases Network and Institute of Biomedicine of the University of Barcelona, 08028 Barcelona, Spain,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
William Rea
2Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ning-Sheng Cai
2Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Aguinaga
1Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Center for Biomedical Research in Neurodegenerative Diseases Network and Institute of Biomedicine of the University of Barcelona, 08028 Barcelona, Spain,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lesley A. Howell
3School of Pharmacy, University of East Anglia, Norwich, NR4 7TJ, United Kingdom, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Felix Hausch
4Max Planck Institute of Psychiatry, 80804 Munich, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Antonio Cortés
1Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Center for Biomedical Research in Neurodegenerative Diseases Network and Institute of Biomedicine of the University of Barcelona, 08028 Barcelona, Spain,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Josefa Mallol
1Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Center for Biomedical Research in Neurodegenerative Diseases Network and Institute of Biomedicine of the University of Barcelona, 08028 Barcelona, Spain,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Josefa Mallol
Vicent Casadó
1Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Center for Biomedical Research in Neurodegenerative Diseases Network and Institute of Biomedicine of the University of Barcelona, 08028 Barcelona, Spain,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carme Lluís
1Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Center for Biomedical Research in Neurodegenerative Diseases Network and Institute of Biomedicine of the University of Barcelona, 08028 Barcelona, Spain,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Carme Lluís
Enric I. Canela
1Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Center for Biomedical Research in Neurodegenerative Diseases Network and Institute of Biomedicine of the University of Barcelona, 08028 Barcelona, Spain,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Enric I. Canela
Sergi Ferré
2Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter J. McCormick
1Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Center for Biomedical Research in Neurodegenerative Diseases Network and Institute of Biomedicine of the University of Barcelona, 08028 Barcelona, Spain,
3School of Pharmacy, University of East Anglia, Norwich, NR4 7TJ, United Kingdom, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4364-14.2015
PubMed 
25926444
Published By 
Society for Neuroscience
History 
  • Received October 21, 2014
  • Revision received February 18, 2015
  • Accepted February 23, 2015
  • First published April 29, 2015.
  • Version of record published April 29, 2015.
Copyright & Usage 
Copyright © 2015 the authors 0270-6474/15/356639-15$15.00/0

Author Information

  1. Gemma Navarro1,*,
  2. César Quiroz2,*,
  3. David Moreno-Delgado1,*,
  4. Adam Sierakowiak2,
  5. Kimberly McDowell2,
  6. Estefanía Moreno1,
  7. William Rea2,
  8. Ning-Sheng Cai2,
  9. David Aguinaga1,
  10. Lesley A. Howell3,
  11. Felix Hausch4,
  12. Antonio Cortés1,
  13. Josefa Mallol1,
  14. Vicent Casadó1,
  15. Carme Lluís1,
  16. Enric I. Canela1,†,
  17. Sergi Ferré2,†, and
  18. Peter J. McCormick1,3,†
  1. 1Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Center for Biomedical Research in Neurodegenerative Diseases Network and Institute of Biomedicine of the University of Barcelona, 08028 Barcelona, Spain,
  2. 2Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224,
  3. 3School of Pharmacy, University of East Anglia, Norwich, NR4 7TJ, United Kingdom, and
  4. 4Max Planck Institute of Psychiatry, 80804 Munich, Germany
View Full Text

Author contributions

  1. Author contributions: G.N., D.M.-D., C.Q., W.R., N.-S.C., D.A., L.A.H., F.H., A.C., J.M., V.C., C.L., E.I.C., S.F., and P.J.M. designed research; G.N., D.M.-D., C.Q., A.S., K.M., W.P.R., E.M., and P.J.M. performed research; G.N., D.M.-D., C.Q., W.R., E.M., C.L., S.F., and P.J.M. analyzed data; G.N., D.M.-D., C.Q., C.L., S.F., and P.J.M. wrote the paper.

  2. ↵*G.N., C.Q., and D.M.D. contributed equally to this manuscript.

Disclosures

    • Received October 21, 2014.
    • Revision received February 18, 2015.
    • Accepted February 23, 2015.
  • ↵†E.I.C., S.F., and P.J.M. are senior co-authors.

  • This work was supported by intramural funds of the National Institute on Drug Abuse, from Spanish Ministry of Science and Technology Grants SAF2011-23813 and SAF2009-07276, Government of Catalonia Grant 2009-SGR-12, and Center for Biomedical Research in Neurodegenerative Diseases Network Grant CB06/05/0064. P.J.M. was supported through a Ramón y Cajal Fellowship. We thank Jasmina Jiménez for technical assistance.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to either of the following: Dr. Sergi Ferré, Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, Triad Technology Building, 333 Cassell Drive, Baltimore, MD 21224, sferre{at}intra.nida.nih.gov; or Dr. Peter J. McCormick, School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK. p.mccormick{at}uea.ac.uk

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2022-07-02
to
E.g., 2022-07-02

Article usage: April 2015 to July 2022

AbstractFullPdf
Apr 2015193953168
May 20152810148214
Jun 20153543636
Jul 20151712521
Aug 20151782119
Sep 20151542620
Oct 20151892222
Nov 20151193423
Dec 2015723225
Total 20155986397548
Jan 20161423726
Feb 20161153011
Mar 2016652525
Apr 2016611915
May 2016542118
Jun 2016542311
Jul 2016471919
Aug 2016691814
Sep 20165376
Oct 2016453110
Nov 2016483829
Dec 2016333924
Total 2016786307208
Jan 2017144811
Feb 2017194011
Mar 201729439
Apr 201718518
May 2017136312
Jun 20174455
Jul 201712366
Aug 201763511
Sep 20175388
Oct 20175264
Nov 201714436
Dec 20179405
Total 201714850896
Jan 201810416
Feb 20186359
Mar 2018184139
Apr 20188638
May 20187475
Jun 2018136812
Jul 20185445
Aug 20186349
Sep 20183409
Oct 201810432
Nov 201810477
Dec 20186512
Total 2018102554113
Jan 201915435
Feb 201918256
Mar 201920239
Apr 2019203914
May 201919189
Jun 201920255
Jul 201917267
Aug 201972112
Sep 2019195113
Oct 2019158012
Nov 2019112810
Dec 20199152
Total 2019190394104
Jan 20202121
Feb 20200168
Mar 20202238
Apr 2020545
May 20209207
Jun 202001410
Jul 2020375
Aug 2020246
Sep 20203229
Oct 20205229
Nov 20207208
Dec 202014237
Total 20205218783
Jan 202192212
Feb 202121318
Mar 2021262915
Apr 2021301814
May 202123178
Jun 2021501912
Jul 2021452014
Aug 2021482010
Sep 2021382213
Oct 2021441530
Nov 2021391414
Dec 202142209
Total 2021415247159
Jan 2022472714
Feb 2022512919
Mar 202256368
Apr 202247287
May 2022442319
Jun 2022472012
Jul 2022200
Total 202229416379
Total797327571390
Back to top

In this issue

The Journal of Neuroscience: 35 (17)
Journal of Neuroscience
Vol. 35, Issue 17
29 Apr 2015
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Advertising (PDF)
  • Ed Board (PDF)
Email

Thank you for sharing this Journal of Neuroscience article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Orexin–Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine
(Your Name) has forwarded a page to you from Journal of Neuroscience
(Your Name) thought you would be interested in this article in Journal of Neuroscience.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Orexin–Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine
Gemma Navarro, César Quiroz, David Moreno-Delgado, Adam Sierakowiak, Kimberly McDowell, Estefanía Moreno, William Rea, Ning-Sheng Cai, David Aguinaga, Lesley A. Howell, Felix Hausch, Antonio Cortés, Josefa Mallol, Vicent Casadó, Carme Lluís, Enric I. Canela, Sergi Ferré, Peter J. McCormick
Journal of Neuroscience 29 April 2015, 35 (17) 6639-6653; DOI: 10.1523/JNEUROSCI.4364-14.2015

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Request Permissions
Share
Orexin–Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine
Gemma Navarro, César Quiroz, David Moreno-Delgado, Adam Sierakowiak, Kimberly McDowell, Estefanía Moreno, William Rea, Ning-Sheng Cai, David Aguinaga, Lesley A. Howell, Felix Hausch, Antonio Cortés, Josefa Mallol, Vicent Casadó, Carme Lluís, Enric I. Canela, Sergi Ferré, Peter J. McCormick
Journal of Neuroscience 29 April 2015, 35 (17) 6639-6653; DOI: 10.1523/JNEUROSCI.4364-14.2015
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • cocaine
  • CRF receptor
  • GPCR heteromer
  • orexin receptor
  • sigma receptor

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

Articles

  • Choice Behavior Guided by Learned, But Not Innate, Taste Aversion Recruits the Orbitofrontal Cortex
  • Maturation of Spontaneous Firing Properties after Hearing Onset in Rat Auditory Nerve Fibers: Spontaneous Rates, Refractoriness, and Interfiber Correlations
  • Insulin Treatment Prevents Neuroinflammation and Neuronal Injury with Restored Neurobehavioral Function in Models of HIV/AIDS Neurodegeneration
Show more Articles

Cellular/Molecular

  • Meclizine and metabotropic glutamate receptor agonists attenuate severe pain and Ca2+ activity of primary sensory neurons in chemotherapy-induced peripheral neuropathy
  • Dendritic Inhibition by Shh Signaling-Dependent Stellate Cell Pool Is Critical for Motor Learning
  • Dual leucine zipper kinase regulates Dscam expression through a non-canonical function of the cytoplasmic poly(A)-binding protein
Show more Cellular/Molecular
  • Home
  • Alerts
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Issue Archive
  • Collections

Information

  • For Authors
  • For Advertisers
  • For the Media
  • For Subscribers

About

  • About the Journal
  • Editorial Board
  • Privacy Policy
  • Contact
(JNeurosci logo)
(SfN logo)

Copyright © 2022 by the Society for Neuroscience.
JNeurosci Online ISSN: 1529-2401

The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.