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Necessary, Yet Dissociable Contributions of the Insular and Ventromedial Prefrontal Cortices to Norm Adaptation: Computational and Lesion Evidence in Humans

Xiaosi Gu, Xingchao Wang, Andreas Hula, Shiwei Wang, Shuai Xu, Terry M. Lohrenz, Robert T. Knight, Zhixian Gao, Peter Dayan and P. Read Montague
Journal of Neuroscience 14 January 2015, 35 (2) 467-473; https://doi.org/10.1523/JNEUROSCI.2906-14.2015
Xiaosi Gu
1Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom WC1N 3BG,
2Human Neuroimaging Laboratory, Virginia Tech Carilion Research Institute, Roanoke, Virginia 24016,
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Xingchao Wang
3Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, and
4China National Clinical Research Center for Neurological Diseases, Beijing, China 100050,
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Andreas Hula
1Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom WC1N 3BG,
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  • ORCID record for Andreas Hula
Shiwei Wang
3Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, and
4China National Clinical Research Center for Neurological Diseases, Beijing, China 100050,
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Shuai Xu
3Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, and
4China National Clinical Research Center for Neurological Diseases, Beijing, China 100050,
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Terry M. Lohrenz
2Human Neuroimaging Laboratory, Virginia Tech Carilion Research Institute, Roanoke, Virginia 24016,
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Robert T. Knight
5Helen Willis Neuroscience Institute and
6Department of Psychology, University of California, Berkeley, California 94720,
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Zhixian Gao
3Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, and
4China National Clinical Research Center for Neurological Diseases, Beijing, China 100050,
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Peter Dayan
7Gatsby Computational Neuroscience Unit, University College London, London, United Kingdom WC1N 3AR, and
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P. Read Montague
1Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom WC1N 3BG,
2Human Neuroimaging Laboratory, Virginia Tech Carilion Research Institute, Roanoke, Virginia 24016,
8Department of Physics, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2906-14.2015
PubMed 
25589742
Published By 
Society for Neuroscience
History 
  • Received July 15, 2014
  • Revision received November 1, 2014
  • Accepted November 3, 2014
  • First published January 14, 2015.
  • Version of record published January 14, 2015.
Copyright & Usage 
Copyright © 2015 Gu et al. This article is freely available online through the J Neurosci Author Open Choice option.

Author Information

  1. Xiaosi Gu1,2,*,
  2. Xingchao Wang3,4,*,
  3. Andreas Hula1,
  4. Shiwei Wang3,4,
  5. Shuai Xu3,4,
  6. Terry M. Lohrenz2,
  7. Robert T. Knight5,6,
  8. Zhixian Gao3,4,
  9. Peter Dayan7, and
  10. P. Read Montague1,2,8
  1. 1Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom WC1N 3BG,
  2. 2Human Neuroimaging Laboratory, Virginia Tech Carilion Research Institute, Roanoke, Virginia 24016,
  3. 3Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, and
  4. 4China National Clinical Research Center for Neurological Diseases, Beijing, China 100050,
  5. 5Helen Willis Neuroscience Institute and
  6. 6Department of Psychology, University of California, Berkeley, California 94720,
  7. 7Gatsby Computational Neuroscience Unit, University College London, London, United Kingdom WC1N 3AR, and
  8. 8Department of Physics, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061
View Full Text

Author contributions

  1. Author contributions: X.G., Z.G., and P.R.M. designed research; X.G., X.W., S.W., S.X., and Z.G. performed research; X.G., A.H., R.T.K., and P.D. analyzed data; X.G., X.W., A.H., T.L., R.K., P.D., and P.R.M. wrote the paper.

  2. ↵*X.G. and X.W. contributed equally to this work.

Disclosures

    • Received July 15, 2014.
    • Revision received November 1, 2014.
    • Accepted November 3, 2014.
  • This work was funded by a Principal Research Fellowship from The Wellcome Trust (P.R.M.), The Kane Family Foundation (P.R.M.), and NINDS Grant 2R37NS21135 (R.T.K.). X.W. and Z.G. are supported by National Natural Science Foundation of China (Grant No. 81328008). P.D. is funded by the Gatsby Charitable Foundation. We thank Jae Shin for help with preparing the task and IT support, Clay Clayworth for help with lesion reconstruction, Ming Hsu for helpful discussions, and Cathy Price for comments on the paper.

  • The authors declare no competing financial interests.

  • This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

  • Correspondence should be addressed to: Dr P. Read Montague, Virginia Tech Carilion Research Institute, 2 Riverside Circle, Roanoke, VA 24011. read{at}vt.edu

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Total47442541349
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The Journal of Neuroscience: 35 (2)
Journal of Neuroscience
Vol. 35, Issue 2
14 Jan 2015
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Necessary, Yet Dissociable Contributions of the Insular and Ventromedial Prefrontal Cortices to Norm Adaptation: Computational and Lesion Evidence in Humans
Xiaosi Gu, Xingchao Wang, Andreas Hula, Shiwei Wang, Shuai Xu, Terry M. Lohrenz, Robert T. Knight, Zhixian Gao, Peter Dayan, P. Read Montague
Journal of Neuroscience 14 January 2015, 35 (2) 467-473; DOI: 10.1523/JNEUROSCI.2906-14.2015

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Necessary, Yet Dissociable Contributions of the Insular and Ventromedial Prefrontal Cortices to Norm Adaptation: Computational and Lesion Evidence in Humans
Xiaosi Gu, Xingchao Wang, Andreas Hula, Shiwei Wang, Shuai Xu, Terry M. Lohrenz, Robert T. Knight, Zhixian Gao, Peter Dayan, P. Read Montague
Journal of Neuroscience 14 January 2015, 35 (2) 467-473; DOI: 10.1523/JNEUROSCI.2906-14.2015
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Keywords

  • brain lesion
  • computational modeling
  • decision-making
  • insular cortex
  • social norms
  • ventromedial prefrontal cortex

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