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Brief Communications

Motor Cortex Layer V Pyramidal Neurons Exhibit Dendritic Regression, Spine Loss, and Increased Synaptic Excitation in the Presymptomatic hSOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

Matthew J. Fogarty, Peter G. Noakes and Mark C. Bellingham
Journal of Neuroscience 14 January 2015, 35 (2) 643-647; https://doi.org/10.1523/JNEUROSCI.3483-14.2015
Matthew J. Fogarty
1School of Biomedical Sciences,
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Peter G. Noakes
1School of Biomedical Sciences,
2Queensland Brain Institute, University of Queensland, St. Lucia, Queensland 4072, Australia
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Mark C. Bellingham
1School of Biomedical Sciences,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.3483-14.2015
PubMed 
25589758
Published By 
Society for Neuroscience
History 
  • Received August 20, 2014
  • Revision received October 21, 2014
  • Accepted November 10, 2014
  • First published January 14, 2015.
  • Version of record published January 14, 2015.
Copyright & Usage 
Copyright © 2015 the authors 0270-6474/15/350643-05$15.00/0

Author Information

  1. Matthew J. Fogarty1,
  2. Peter G. Noakes1,2,*, and
  3. Mark C. Bellingham1,*
  1. 1School of Biomedical Sciences,
  2. 2Queensland Brain Institute, University of Queensland, St. Lucia, Queensland 4072, Australia
View Full Text

Author contributions

  1. Author contributions: M.J.F., P.G.N., and M.C.B. designed research; M.J.F. performed research; M.J.F. and M.C.B. analyzed data; M.J.F., P.G.N., and M.C.B. wrote the paper.

  2. ↵*P.G.N. and M.C.B. contributed equally to this study.

Disclosures

    • Received August 20, 2014.
    • Revision received October 21, 2014.
    • Accepted November 10, 2014.
  • The work was supported by grants to M.C.B. and P.G.N. (National Health and Medical Research Council Project Grant 1065884 and Motor Neuron Disease Research Institute Australia). We thank Dr. S. Ngo for providing experimental animals, M. Shayegh and M. White for genotyping, and L. Hammond and Dr. D. Matthews for microscopy assistance (Australia Research Council Linkage Infrastructure, Equipment and Facilities Grant LE100100074).

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Mark C. Bellingham, School of Biomedical Sciences, University of Queensland, St. Lucia, Queensland 4072, Australia. mark.bellingham{at}uq.edu.au

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Aug 202584619
Sep 2025116328
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Total 202590574221
Total77645751598
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The Journal of Neuroscience: 35 (2)
Journal of Neuroscience
Vol. 35, Issue 2
14 Jan 2015
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Motor Cortex Layer V Pyramidal Neurons Exhibit Dendritic Regression, Spine Loss, and Increased Synaptic Excitation in the Presymptomatic hSOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis
Matthew J. Fogarty, Peter G. Noakes, Mark C. Bellingham
Journal of Neuroscience 14 January 2015, 35 (2) 643-647; DOI: 10.1523/JNEUROSCI.3483-14.2015

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Motor Cortex Layer V Pyramidal Neurons Exhibit Dendritic Regression, Spine Loss, and Increased Synaptic Excitation in the Presymptomatic hSOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis
Matthew J. Fogarty, Peter G. Noakes, Mark C. Bellingham
Journal of Neuroscience 14 January 2015, 35 (2) 643-647; DOI: 10.1523/JNEUROSCI.3483-14.2015
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