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Articles, Neurobiology of Disease

Early and Persistent Abnormal Decoding by Glial Cells at the Neuromuscular Junction in an ALS Model

Danielle Arbour, Elsa Tremblay, Éric Martineau, Jean-Pierre Julien and Richard Robitaille
Journal of Neuroscience 14 January 2015, 35 (2) 688-706; https://doi.org/10.1523/JNEUROSCI.1379-14.2015
Danielle Arbour
1Département de neurosciences, Université de Montréal, Montréal, Québec H3C 3J7, Canada,
2Groupe de recherche sur le système nerveux central, Université de Montréal, Station centre-ville, Montréal, Québec H3C 3J7, Canada, and
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Elsa Tremblay
1Département de neurosciences, Université de Montréal, Montréal, Québec H3C 3J7, Canada,
2Groupe de recherche sur le système nerveux central, Université de Montréal, Station centre-ville, Montréal, Québec H3C 3J7, Canada, and
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Éric Martineau
1Département de neurosciences, Université de Montréal, Montréal, Québec H3C 3J7, Canada,
2Groupe de recherche sur le système nerveux central, Université de Montréal, Station centre-ville, Montréal, Québec H3C 3J7, Canada, and
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Jean-Pierre Julien
3Département de psychiatrie et de neurosciences, Université Laval, Québec G1V 0A6, Canada
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Richard Robitaille
1Département de neurosciences, Université de Montréal, Montréal, Québec H3C 3J7, Canada,
2Groupe de recherche sur le système nerveux central, Université de Montréal, Station centre-ville, Montréal, Québec H3C 3J7, Canada, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1379-14.2015
PubMed 
25589763
Published By 
Society for Neuroscience
History 
  • Received April 2, 2014
  • Revision received November 14, 2014
  • Accepted November 14, 2014
  • First published January 14, 2015.
  • Version of record published January 14, 2015.
Copyright & Usage 
Copyright © 2015 the authors 0270-6474/15/350688-19$15.00/0

Author Information

  1. Danielle Arbour1,2,
  2. Elsa Tremblay1,2,
  3. Éric Martineau1,2,
  4. Jean-Pierre Julien3, and
  5. Richard Robitaille1,2
  1. 1Département de neurosciences, Université de Montréal, Montréal, Québec H3C 3J7, Canada,
  2. 2Groupe de recherche sur le système nerveux central, Université de Montréal, Station centre-ville, Montréal, Québec H3C 3J7, Canada, and
  3. 3Département de psychiatrie et de neurosciences, Université Laval, Québec G1V 0A6, Canada
View Full Text

Author contributions

  1. Author contributions: D.A. and R.R. designed research; D.A., E.T., and É.M. performed research; J.-P.J. contributed unpublished reagents/analytic tools; D.A., E.T., É.M., and R.R. analyzed data; D.A. and R.R. wrote the paper.

Disclosures

    • Received April 2, 2014.
    • Revision received November 14, 2014.
    • Accepted November 14, 2014.
  • This work was supported by Canadian Institutes for Health Research Grants MOP-14137, MOP-111070, a Bernice Ramsay Discovery grant from ALS Society of Canada, Canadian Foundation of Innovation to R.R., and Fonds Recherche Quebec-Santé Leader Opportunity Fund to the Groupe de recherche sur le Système Nerveux Central infrastructure grant. D.A. held a studentship from National Science Engineering Research Council of Canada. E.T. and É.M. each held a Fonds Recherche Quebec-Santé studentship. We thank Dr. Jannic Boehm for comments over the course of this work; Dr. Christine Vande Velde for her constant support, stimulating discussions, and for reading and commenting on the manuscript; and Joanne Vallée and Julie Pépin for technical support.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr. Richard Robitaille, Département de neurosciences, Université de Montréal, Montréal, Québec H3C 3J7, Canada. richard.robitaille{at}umontreal.ca

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Apr 2025125931
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Total 202559250104
Total63852421272
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The Journal of Neuroscience: 35 (2)
Journal of Neuroscience
Vol. 35, Issue 2
14 Jan 2015
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Early and Persistent Abnormal Decoding by Glial Cells at the Neuromuscular Junction in an ALS Model
Danielle Arbour, Elsa Tremblay, Éric Martineau, Jean-Pierre Julien, Richard Robitaille
Journal of Neuroscience 14 January 2015, 35 (2) 688-706; DOI: 10.1523/JNEUROSCI.1379-14.2015

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Early and Persistent Abnormal Decoding by Glial Cells at the Neuromuscular Junction in an ALS Model
Danielle Arbour, Elsa Tremblay, Éric Martineau, Jean-Pierre Julien, Richard Robitaille
Journal of Neuroscience 14 January 2015, 35 (2) 688-706; DOI: 10.1523/JNEUROSCI.1379-14.2015
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Keywords

  • motor unit properties
  • muscarinic receptors
  • perisynaptic Schwann cells
  • SOD1
  • synaptic transmission

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