Article Information
- Received October 8, 2014
- Revision received March 2, 2015
- Accepted April 1, 2015
- First published May 27, 2015.
- Version of record published May 27, 2015.
Author Information
- Maria Praggastis1,
- Brett Tortelli1,
- Jessie Zhang1,
- Hideji Fujiwara1,
- Rohini Sidhu1,
- Anita Chacko1,
- Zhouji Chen1,
- Chan Chung2,
- Andrew P. Lieberman2,
- Jakub Sikora3,
- Cristin Davidson3,
- Steven U. Walkley3,
- Nina H. Pipalia4,
- Frederick R. Maxfield4,
- Jean E. Schaffer1, and
- Daniel S. Ory1
- 1Diabetic Cardiovascular Disease Center and Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110,
- 2Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109,
- 3Dominick P. Purpura Department of Neuroscience, Rose F. Kennedy Intellectual and Developmental Disabilities Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, and
- 4Department of Biochemistry, Weill Cornell Medical College, New York, New York 10065
Author contributions
Author contributions: M.P., J.E.S., and D.S.O. designed research; M.P., B.T., J.Z., H.F., R.S., A.C., Z.C., C.C., J.S., C.D., and N.H.P. performed research; A.P.L. and D.S.O. contributed unpublished reagents/analytic tools; M.P., B.T., J.Z., H.F., R.S., J.S., C.D., S.U.W., N.H.P., F.R.M., J.E.S., and D.S.O. analyzed data; M.P., J.S., C.D., S.U.W., F.R.M., J.E.S., and D.S.O. wrote the paper.
Disclosures
- Received October 8, 2014.
- Revision received March 2, 2015.
- Accepted April 1, 2015.
This work was supported by grants from the Hide & Seek Foundation (D.S.O.), Dana's Angels Research Trust (D.S.O., C.D., and S.U.W.), and the Ara Parseghian Medical Research Foundation (F.R.M.) and by NIH Grants R01 NS081985 (D.S.O. and J.E.S.), R37 DK27083 (F.R.M.), R01 NS063967 (A.P.L.), R01 NS053677 (S.U.W.), R01 HD045561 (S.U.W.), and P30 HD071593 (S.U.W.), and F05 NS074790 (J.S.). This work was performed in the Metabolomics Facility at Washington University (NIH Grant P30 DK020579) and was supported in part by the Hope Center Transgenic Vectors Core at Washington University School of Medicine. We are grateful to Renate Lewis for assistance with generation of the knock-in mouse line. The LAMP1 antibody 1D4B was obtained from the Developmental Studies Hybridoma Bank, created by the NICHD of the NIH, and maintained at The University of Iowa.
The authors declare no competing financial interests.
- Correspondence should be addressed to Dr. Daniel S. Ory, Diabetic Cardiovascular Disease Center, Washington University School of Medicine, Box 8086, 660 S. Euclid Avenue, St. Louis, MO 63110. dory{at}wustl.edu
Online Impact