Cover legend: This hippocampal neuron, 14 d in vitro, lacks NMDA receptor subunit GluN2B. It was immunostained for the AMPA receptor subunit GluA1 (green), the vesicular glutamate transporter VGLUT1 (red), and the microtubule-associated protein MAP2 (blue). An edge-detect filter was used to enhance color and cluster contour. In the absence of the GluN2B subunit, synaptic clustering of AMPA receptors is increased as a result of impaired anchoring of the synaptic proteasome. For more information, see the article by Ferreira et al. (pages 8462–8479).