Cover legend: This image shows a transverse section of mouse lumbar spinal cord taken 7 d after partial sciatic nerve ligation. The section is stained for microglial markers Iba1 (red) and phosphorylated p-38 MAPK (green), as well as the nuclear marker DAPI (blue). The orphan G-protein receptor 84 (GPR84) is markedly induced in macrophages and microglia during inflammation, and it contributes to the development of mechanical and thermal hypersensitivity. For more information, see the article by Nicol et al. (pages 8959–8969).