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Articles, Behavioral/Cognitive

Linkage Analysis in a Dutch Population Isolate Shows No Major Gene for Left-Handedness or Atypical Language Lateralization

Metten Somers, Roel A. Ophoff, Maartje F. Aukes, Rita M. Cantor, Marco P. Boks, Meenakshi Dauwan, Kees L. de Visser, René S. Kahn and Iris E. Sommer
Journal of Neuroscience 10 June 2015, 35 (23) 8730-8736; DOI: https://doi.org/10.1523/JNEUROSCI.3287-14.2015
Metten Somers
1Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands,
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  • ORCID record for Metten Somers
Roel A. Ophoff
1Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands,
2Department of Human Genetics David Geffen School of Medicine at University of California, Los Angeles, Gonda (Goldschmied) Neuroscience and Genetics Research Center, Los Angeles, California 90095-7088,
3Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Los Angeles, California 90095-1761, and
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Maartje F. Aukes
1Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands,
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Rita M. Cantor
2Department of Human Genetics David Geffen School of Medicine at University of California, Los Angeles, Gonda (Goldschmied) Neuroscience and Genetics Research Center, Los Angeles, California 90095-7088,
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Marco P. Boks
1Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands,
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Meenakshi Dauwan
1Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands,
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Kees L. de Visser
4Department of General Practice, University Medical Center Groningen, University of Groningen, 9700 AD Groningen, The Netherlands
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René S. Kahn
1Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands,
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Iris E. Sommer
1Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.3287-14.2015
PubMed 
26063907
Published By 
Society for Neuroscience
History 
  • Received August 1, 2014
  • Revision received April 4, 2015
  • Accepted April 10, 2015
  • First published June 10, 2015.
  • Version of record published June 10, 2015.
Copyright & Usage 
Copyright © 2015 the authors 0270-6474/15/358730-07$15.00/0

Author Information

  1. Metten Somers1,
  2. Roel A. Ophoff1,2,3,
  3. Maartje F. Aukes1,
  4. Rita M. Cantor2,
  5. Marco P. Boks1,
  6. Meenakshi Dauwan1,
  7. Kees L. de Visser4,
  8. René S. Kahn1, and
  9. Iris E. Sommer1
  1. 1Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands,
  2. 2Department of Human Genetics David Geffen School of Medicine at University of California, Los Angeles, Gonda (Goldschmied) Neuroscience and Genetics Research Center, Los Angeles, California 90095-7088,
  3. 3Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Los Angeles, California 90095-1761, and
  4. 4Department of General Practice, University Medical Center Groningen, University of Groningen, 9700 AD Groningen, The Netherlands
View Full Text

Author contributions

  1. Author contributions: M.S., R.A.O., M.F.A., M.P.B., K.C.L.d.V., R.S.K., and I.E.S. designed research; M.S. and M.D. performed research; M.S., R.M.C., and M.P.B. analyzed data; M.S., M.F.A., and I.E.S. wrote the paper.

Disclosures

    • Received August 1, 2014.
    • Revision received April 4, 2015.
    • Accepted April 10, 2015.
  • This study was supported by MD Clinical Research Trainee Grant ZonMw 40-00703-98-8571 and a National Alliance for Research on Schizophrenia and Depression Independent investigator grant (I.S.). Statistical analyses were performed on the Genetic Cluster Computer (www.geneticcluster.org), which is financially supported by Netherlands Scientific Organization Grant 480-05-003. Some of the results were obtained by using the software package S.A.G.E., which was supported by U.S. Public Health Service Resource Grant RR03655 from the National Center for Research Resources. We thank E. Strengman and R. van 't Slot for their assistance in the genotyping procedures, Dr K. R. van Eijk for her advice on formatting raw data, and A. Bos-Korf, M. Essed, W. Fleer, C. van de Moosdijk, F. M. van Nieuwenhuijze, A. Oost-Korf, and E. Schrijver for their role in the data collection.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Metten Somers, Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, A01.4.68, P.O. Box 85500, 3508 GA Utrecht, The Netherlands. M.Somers{at}umcutrecht.nl

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The Journal of Neuroscience: 35 (23)
Journal of Neuroscience
Vol. 35, Issue 23
10 Jun 2015
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Linkage Analysis in a Dutch Population Isolate Shows No Major Gene for Left-Handedness or Atypical Language Lateralization
Metten Somers, Roel A. Ophoff, Maartje F. Aukes, Rita M. Cantor, Marco P. Boks, Meenakshi Dauwan, Kees L. de Visser, René S. Kahn, Iris E. Sommer
Journal of Neuroscience 10 June 2015, 35 (23) 8730-8736; DOI: 10.1523/JNEUROSCI.3287-14.2015

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Linkage Analysis in a Dutch Population Isolate Shows No Major Gene for Left-Handedness or Atypical Language Lateralization
Metten Somers, Roel A. Ophoff, Maartje F. Aukes, Rita M. Cantor, Marco P. Boks, Meenakshi Dauwan, Kees L. de Visser, René S. Kahn, Iris E. Sommer
Journal of Neuroscience 10 June 2015, 35 (23) 8730-8736; DOI: 10.1523/JNEUROSCI.3287-14.2015
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Keywords

  • asymmetry
  • genetics
  • hand-preference
  • language lateralization
  • left-handedness
  • linkage analysis

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