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Articles, Behavioral/Cognitive

Linkage Analysis in a Dutch Population Isolate Shows No Major Gene for Left-Handedness or Atypical Language Lateralization

Metten Somers, Roel A. Ophoff, Maartje F. Aukes, Rita M. Cantor, Marco P. Boks, Meenakshi Dauwan, Kees L. de Visser, René S. Kahn and Iris E. Sommer
Journal of Neuroscience 10 June 2015, 35 (23) 8730-8736; DOI: https://doi.org/10.1523/JNEUROSCI.3287-14.2015
Metten Somers
1Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands,
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  • ORCID record for Metten Somers
Roel A. Ophoff
1Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands,
2Department of Human Genetics David Geffen School of Medicine at University of California, Los Angeles, Gonda (Goldschmied) Neuroscience and Genetics Research Center, Los Angeles, California 90095-7088,
3Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Los Angeles, California 90095-1761, and
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Maartje F. Aukes
1Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands,
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Rita M. Cantor
2Department of Human Genetics David Geffen School of Medicine at University of California, Los Angeles, Gonda (Goldschmied) Neuroscience and Genetics Research Center, Los Angeles, California 90095-7088,
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Marco P. Boks
1Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands,
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Meenakshi Dauwan
1Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands,
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Kees L. de Visser
4Department of General Practice, University Medical Center Groningen, University of Groningen, 9700 AD Groningen, The Netherlands
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René S. Kahn
1Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands,
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Iris E. Sommer
1Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands,
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    Figure 1.

    Linkage results in pruned datasets, showing RS numbers on the x-axis and LOD scores on the y-axis (HLOD for parametric analysis) for left-handedness, parametric analysis, chromosome 22 (A), left-handedness, nonparametric analysis, chromosome 22 (B), atypical lateralization, nonparametric analysis, chromosome 7 (C), hand preference, quantitative trait loci (QTL), nonparametric analysis, chromosome 6 (D), language lateralization, QTL, nonparametric analysis, chromosome 7 (E), and language lateralization, nonparametric analysis, chromosome 9 (F).

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    Table 1.

    Suggestive linkage regions showing trait, type of analysis, the top SNP, chromosomal region, and LOD score (HLOD for parametric analysis)

    TraitAnalysisSNPChromosomeLOD
    Left-handednessMajor gene modelrs72859222q132.18
    Left-handednessModel freers93249722q132.80
    Atypical lateralizationModel freers9408647q342.35
    Strength of language lateralization (QTL)Model freers21804196p222.46
    Strength of language lateralization (QTL)Model freers7293327q321.93
    Strength of language lateralization (QTL)Model freers9146529q332.19
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The Journal of Neuroscience: 35 (23)
Journal of Neuroscience
Vol. 35, Issue 23
10 Jun 2015
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Linkage Analysis in a Dutch Population Isolate Shows No Major Gene for Left-Handedness or Atypical Language Lateralization
Metten Somers, Roel A. Ophoff, Maartje F. Aukes, Rita M. Cantor, Marco P. Boks, Meenakshi Dauwan, Kees L. de Visser, René S. Kahn, Iris E. Sommer
Journal of Neuroscience 10 June 2015, 35 (23) 8730-8736; DOI: 10.1523/JNEUROSCI.3287-14.2015

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Linkage Analysis in a Dutch Population Isolate Shows No Major Gene for Left-Handedness or Atypical Language Lateralization
Metten Somers, Roel A. Ophoff, Maartje F. Aukes, Rita M. Cantor, Marco P. Boks, Meenakshi Dauwan, Kees L. de Visser, René S. Kahn, Iris E. Sommer
Journal of Neuroscience 10 June 2015, 35 (23) 8730-8736; DOI: 10.1523/JNEUROSCI.3287-14.2015
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Keywords

  • asymmetry
  • genetics
  • hand-preference
  • language lateralization
  • left-handedness
  • linkage analysis

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