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Articles, Cellular/Molecular

Potent KCNQ2/3-Specific Channel Activator Suppresses In Vivo Epileptic Activity and Prevents the Development of Tinnitus

Bopanna I. Kalappa, Heun Soh, Kevin M. Duignan, Takeru Furuya, Scott Edwards, Anastasios V. Tzingounis and Thanos Tzounopoulos
Journal of Neuroscience 10 June 2015, 35 (23) 8829-8842; https://doi.org/10.1523/JNEUROSCI.5176-14.2015
Bopanna I. Kalappa
1Department of Otolaryngology and Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261,
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Heun Soh
2Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269, and
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Kevin M. Duignan
2Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269, and
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Takeru Furuya
3SciFluor Life Sciences, Inc., Cambridge, Massachusetts 02139
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Scott Edwards
3SciFluor Life Sciences, Inc., Cambridge, Massachusetts 02139
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Anastasios V. Tzingounis
2Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269, and
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Thanos Tzounopoulos
1Department of Otolaryngology and Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.5176-14.2015
PubMed 
26063916
Published By 
Society for Neuroscience
History 
  • Received December 19, 2014
  • Revision received April 4, 2015
  • Accepted April 27, 2015
  • First published June 10, 2015.
  • Version of record published June 10, 2015.
Copyright & Usage 
Copyright © 2015 the authors 0270-6474/15/358829-14$15.00/0

Author Information

  1. Bopanna I. Kalappa1,*,
  2. Heun Soh2,*,
  3. Kevin M. Duignan2,
  4. Takeru Furuya3,
  5. Scott Edwards3,
  6. Anastasios V. Tzingounis2, and
  7. Thanos Tzounopoulos1
  1. 1Department of Otolaryngology and Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261,
  2. 2Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269, and
  3. 3SciFluor Life Sciences, Inc., Cambridge, Massachusetts 02139
View Full Text

Author contributions

  1. Author contributions: B.I.K., S.E., A.V.T., and T.T. designed research; B.I.K., H.S., K.M.D., and T.F. performed research; S.E. contributed unpublished reagents/analytic tools; B.I.K., T.F., S.E., A.V.T., and T.T. analyzed data; B.I.K., S.E., A.V.T., and T.T. wrote the paper.

  2. ↵*B.I.K. and H.S. contributed equally to this work.

Disclosures

    • Received December 19, 2014.
    • Revision received April 4, 2015.
    • Accepted April 27, 2015.
  • This work was supported by the Department of Defense (Peer Reviewed Medical Research Program Grant PR093405 to T.T.), the Joint Warfighter Medical Research Program (Grant W81XWH-14-1-0117 to T.T.), and the National Institutes of Health (Grant NS073981 to A.V.T.). We thank the National Institute of Neurological Disorders and Stroke–National Institutes of Health anticonvulsant screening program at the University of Utah for performing the anticonvulsant and toxicity studies; Adam Whiteley and Inga Kristaponyte for helping with experiments assessing the behavioral evidence of tinnitus; and Cindy Ling for help in making the figures.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to either of the following: Thanos Tzounopoulos, Department of Otolaryngology and Neurobiology, Bio-Medical Science Tower 3, Room 3, 3501 Fifth Ave., 10021 BST 3, University of Pittsburgh, Pittsburgh, PA 15261, thanos{at}pitt.edu; or Anastasios V. Tzingounis, Department of Physiology and Neurobiology, 75 North Eagleville Road, University of Connecticut, Storrs, CT 06269, anastasios.tzingounis{at}uconn.edu

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Jan 2018115717
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Jan 2025105524
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Total 202550516100
Total232869641704
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The Journal of Neuroscience: 35 (23)
Journal of Neuroscience
Vol. 35, Issue 23
10 Jun 2015
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Potent KCNQ2/3-Specific Channel Activator Suppresses In Vivo Epileptic Activity and Prevents the Development of Tinnitus
Bopanna I. Kalappa, Heun Soh, Kevin M. Duignan, Takeru Furuya, Scott Edwards, Anastasios V. Tzingounis, Thanos Tzounopoulos
Journal of Neuroscience 10 June 2015, 35 (23) 8829-8842; DOI: 10.1523/JNEUROSCI.5176-14.2015

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Potent KCNQ2/3-Specific Channel Activator Suppresses In Vivo Epileptic Activity and Prevents the Development of Tinnitus
Bopanna I. Kalappa, Heun Soh, Kevin M. Duignan, Takeru Furuya, Scott Edwards, Anastasios V. Tzingounis, Thanos Tzounopoulos
Journal of Neuroscience 10 June 2015, 35 (23) 8829-8842; DOI: 10.1523/JNEUROSCI.5176-14.2015
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Keywords

  • KCNQ channels
  • epilepsy
  • tinnitus

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