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Articles, Neurobiology of Disease

Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease

Nikhil Panicker, Hariharan Saminathan, Huajun Jin, Matthew Neal, Dilshan S. Harischandra, Richard Gordon, Kavin Kanthasamy, Vivek Lawana, Souvarish Sarkar, Jie Luo, Vellareddy Anantharam, Anumantha G. Kanthasamy and Arthi Kanthasamy
Journal of Neuroscience 8 July 2015, 35 (27) 10058-10077; DOI: https://doi.org/10.1523/JNEUROSCI.0302-15.2015
Nikhil Panicker
Parkinson Disorders Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011
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Hariharan Saminathan
Parkinson Disorders Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011
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Huajun Jin
Parkinson Disorders Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011
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Matthew Neal
Parkinson Disorders Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011
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Dilshan S. Harischandra
Parkinson Disorders Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011
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  • ORCID record for Dilshan S. Harischandra
Richard Gordon
Parkinson Disorders Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011
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Kavin Kanthasamy
Parkinson Disorders Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011
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Vivek Lawana
Parkinson Disorders Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011
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Souvarish Sarkar
Parkinson Disorders Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011
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Jie Luo
Parkinson Disorders Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011
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Vellareddy Anantharam
Parkinson Disorders Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011
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Anumantha G. Kanthasamy
Parkinson Disorders Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011
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Arthi Kanthasamy
Parkinson Disorders Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0302-15.2015
PubMed 
26157004
Published By 
Society for Neuroscience
History 
  • Received January 22, 2015
  • Revision received May 14, 2015
  • Accepted June 3, 2015
  • First published July 8, 2015.
  • Version of record published July 8, 2015.
Copyright & Usage 
Copyright © 2015 the authors 0270-6474/15/3510058-20$15.00/0

Author Information

  1. Nikhil Panicker,
  2. Hariharan Saminathan,
  3. Huajun Jin,
  4. Matthew Neal,
  5. Dilshan S. Harischandra,
  6. Richard Gordon,
  7. Kavin Kanthasamy,
  8. Vivek Lawana,
  9. Souvarish Sarkar,
  10. Jie Luo,
  11. Vellareddy Anantharam,
  12. Anumantha G. Kanthasamy, and
  13. Arthi Kanthasamy
  1. Parkinson Disorders Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011
  • K. Kanthasamy's present address: Baylor College of Medicine, Houston, TX 77005.

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Author contributions

  1. Author contributions: N.P., A.G.K., and A.K. designed research; N.P., H.S., H.J., M.N., D.S.H., R.G., K.K., V.L., S.S., and J.L. performed research; N.P., H.J., and A.K. analyzed data; N.P., H.J., V.A., A.G.K., and A.K. wrote the paper.

  • K. Kanthasamy's present address: Baylor College of Medicine, Houston, TX 77005.

Disclosures

    • Received January 22, 2015.
    • Revision received May 14, 2015.
    • Accepted June 3, 2015.
  • This work was supported by National Institutes of Health Grants NS088206, ES10586, and NS78247, the W. Eugene and Linda Lloyd Endowed Chair to A.G.K., and the Dean Endowed Professorship to A.K. We thank Gary Zenitsky for assistance in preparing the manuscript.

  • A.G.K. and V.A. are shareholders of PK Biosciences Corporation (Ames, Iowa), which is interested in translating mechanistic studies into therapies targeting kinases, including Fyn. The remaining authors have no conflicts of interest.

  • Correspondence should be addressed to Dr. Arthi Kanthasamy, Parkinson Disorders Research Laboratory, Department of Biomedical Sciences, 2016 Veterinary Medicine Building, Iowa State University, Ames, IA 50011. arthik{at}iastate.edu

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The Journal of Neuroscience: 35 (27)
Journal of Neuroscience
Vol. 35, Issue 27
8 Jul 2015
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Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease
Nikhil Panicker, Hariharan Saminathan, Huajun Jin, Matthew Neal, Dilshan S. Harischandra, Richard Gordon, Kavin Kanthasamy, Vivek Lawana, Souvarish Sarkar, Jie Luo, Vellareddy Anantharam, Anumantha G. Kanthasamy, Arthi Kanthasamy
Journal of Neuroscience 8 July 2015, 35 (27) 10058-10077; DOI: 10.1523/JNEUROSCI.0302-15.2015

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Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease
Nikhil Panicker, Hariharan Saminathan, Huajun Jin, Matthew Neal, Dilshan S. Harischandra, Richard Gordon, Kavin Kanthasamy, Vivek Lawana, Souvarish Sarkar, Jie Luo, Vellareddy Anantharam, Anumantha G. Kanthasamy, Arthi Kanthasamy
Journal of Neuroscience 8 July 2015, 35 (27) 10058-10077; DOI: 10.1523/JNEUROSCI.0302-15.2015
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Keywords

  • Fyn
  • kinase
  • microglia
  • neuroinflammation
  • Parkinson's disease
  • phosphorylation

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