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Articles, Cellular/Molecular

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

Fu-Lei Tang, Joanna R. Erion, Yun Tian, Wei Liu, Dong-Min Yin, Jian Ye, Baisha Tang, Lin Mei and Wen-Cheng Xiong
Journal of Neuroscience 22 July 2015, 35 (29) 10613-10628; DOI: https://doi.org/10.1523/JNEUROSCI.0042-15.2015
Fu-Lei Tang
1Departments of Neuroscience and Regenerative Medicine and Neurology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia 30912,
2Charlie Norwood VA Medical Center, Augusta, Georgia 30912,
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Joanna R. Erion
1Departments of Neuroscience and Regenerative Medicine and Neurology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia 30912,
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Yun Tian
1Departments of Neuroscience and Regenerative Medicine and Neurology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia 30912,
3Department of Neurology, Xiang-Ya Hospital, Central South University, Changsha, Hunan, P.R. China 410083, and
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Wei Liu
1Departments of Neuroscience and Regenerative Medicine and Neurology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia 30912,
4Department of Ophthalmology and Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, P.R. China 400042
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Dong-Min Yin
1Departments of Neuroscience and Regenerative Medicine and Neurology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia 30912,
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Jian Ye
4Department of Ophthalmology and Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, P.R. China 400042
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Baisha Tang
3Department of Neurology, Xiang-Ya Hospital, Central South University, Changsha, Hunan, P.R. China 410083, and
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Lin Mei
1Departments of Neuroscience and Regenerative Medicine and Neurology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia 30912,
2Charlie Norwood VA Medical Center, Augusta, Georgia 30912,
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Wen-Cheng Xiong
1Departments of Neuroscience and Regenerative Medicine and Neurology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia 30912,
2Charlie Norwood VA Medical Center, Augusta, Georgia 30912,
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The Journal of Neuroscience: 35 (29)
Journal of Neuroscience
Vol. 35, Issue 29
22 Jul 2015
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VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease
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VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease
Fu-Lei Tang, Joanna R. Erion, Yun Tian, Wei Liu, Dong-Min Yin, Jian Ye, Baisha Tang, Lin Mei, Wen-Cheng Xiong
Journal of Neuroscience 22 July 2015, 35 (29) 10613-10628; DOI: 10.1523/JNEUROSCI.0042-15.2015

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VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease
Fu-Lei Tang, Joanna R. Erion, Yun Tian, Wei Liu, Dong-Min Yin, Jian Ye, Baisha Tang, Lin Mei, Wen-Cheng Xiong
Journal of Neuroscience 22 July 2015, 35 (29) 10613-10628; DOI: 10.1523/JNEUROSCI.0042-15.2015
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Keywords

  • α-synuclein
  • autophagy
  • LAMP2a
  • Parkinson's disease
  • VPS35

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