Article Information
- Received June 13, 2014
- Revision received November 20, 2014
- Accepted November 21, 2014
- First published January 21, 2015.
- Version of record published January 21, 2015.
Author Information
- Ruirui Lu1,2,*,
- Anne E. Bausch3,*,
- Wiebke Kallenborn-Gerhardt2,
- Carsten Stoetzer4,
- Natasja Debruin5,
- Peter Ruth3,
- Gerd Geisslinger2,5,
- Andreas Leffler4,
- Robert Lukowski3,*, and
- Achim Schmidtko1,2,*
- 1Institut für Pharmakologie und Toxikologie, Universität Witten/Herdecke, Zentrum für Biomedizinische Ausbildung und Forschung, 58453 Witten, Germany,
- 2Pharmazentrum Frankfurt/Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit, Institut für Klinische Pharmakologie, Universitätsklinikum Frankfurt, 60590 Frankfurt am Main, Germany,
- 3Pharmakologie, Toxikologie und Klinische Pharmazie, Institut für Pharmazie, 72076 Tübingen, Germany,
- 4Klinik für Anästhesiologie und Intensivmedizin, Medizinische Hochschule Hannover, 30625 Hannover, Germany, and
- 5Fraunhofer Institute for Molecular Biology and Applied Ecology IME, 60590 Frankfurt am Main, Germany
Author contributions
Author contributions: R. Lu, A.E.B., P.R., G.G., A.L., R. Lukowski, and A.S. designed research; R. Lu, A.E.B., W.K.-G., C.S., N.D., and A.L. performed research; A.E.B., P.R., and R. Lukowski contributed unpublished reagents/analytic tools; R. Lu and A.S. analyzed data; R. Lu and A.S. wrote the paper.
↵*R. Lu, A.B., R. Lukowski, and A.S. contributed equally to this work.
Disclosures
- Received June 13, 2014.
- Revision received November 20, 2014.
- Accepted November 21, 2014.
This work was supported by grants from the Doktor Robert Pfleger-Stiftung (to A.S.), the Witten/Herdecke University (to A.S.), the Deutsche Forschungsgemeinschaft (SFB 815-A14; to G.G. and A.S.), and the Landesapothekerkammer Baden-Württemberg (to A.B. and P.R.). We thank Prof. Rohini Kuner (Institute of Pharmacology, Heidelberg) for providing SNS-Cre mice and Natalie Wolfsdorff, Christine Manderscheid, Karin Schilling, and Clement Kabagema-Bilan for excellent technical assistance.
The authors declare no competing financial interests.
- Correspondence should be addressed to either of the following: Prof. Achim Schmidtko, Institut für Pharmakologie und Toxikologie, Universität Witten/Herdecke, Stockumer Str. 10, 58453 Witten, Germany. achim.schmidtko{at}uni-wh.de; or JProf. Dr. Robert Lukowski, LS für Pharmakologie, Toxikologie und Klinische Pharmazie, Institut für Pharmazie, Auf der Morgenstelle 8, 72076 Tübingen, Germany. robert.lukowski{at}uni-tuebingen.de
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