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Brief Communications

Autocrine Boost of NMDAR Current in Hippocampal CA1 Pyramidal Neurons by a PMCA-Dependent, Perisynaptic, Extracellular pH Shift

Huei-Ying Chen and Mitchell Chesler
Journal of Neuroscience 21 January 2015, 35 (3) 873-877; https://doi.org/10.1523/JNEUROSCI.2293-14.2015
Huei-Ying Chen
1Department of Neuroscience and Physiology and
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Mitchell Chesler
1Department of Neuroscience and Physiology and
2Department of Neurosurgery, New York University School of Medicine, New York, New York 10016
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2293-14.2015
PubMed 
25609607
Published By 
Society for Neuroscience
History 
  • Received June 4, 2014
  • Revision received October 31, 2014
  • Accepted November 17, 2014
  • First published January 21, 2015.
  • Version of record published January 21, 2015.
Copyright & Usage 
Copyright © 2015 the authors 0270-6474/15/350873-05$15.00/0

Author Information

  1. Huei-Ying Chen1 and
  2. Mitchell Chesler1,2
  1. 1Department of Neuroscience and Physiology and
  2. 2Department of Neurosurgery, New York University School of Medicine, New York, New York 10016
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Author contributions

  1. Author contributions: H.-Y.C. and M.C. designed research; H.-Y.C. performed research; H.-Y.C. and M.C. analyzed data; H.-Y.C. and M.C. wrote the paper.

Disclosures

    • Received June 4, 2014.
    • Revision received October 31, 2014.
    • Accepted November 17, 2014.
  • This work was supported by the National Institutes of Health, National Institute of Neurological Disorders and Stroke (Grant NS032123) and the Attilio and Olympia Ricciardi Fund. We thank N. Galifianakis, A. Paulson, S. Makani, W. Sly, and A. Waheed for critical feedback.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr. Mitchell Chesler, Department of Neuroscience and Physiology and Department of Neurosurgery, New York University School of Medicine, 550 First Avenue, New York, NY 10016. Mitchell.Chesler{at}nyumc.org

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Jan 20184181
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The Journal of Neuroscience: 35 (3)
Journal of Neuroscience
Vol. 35, Issue 3
21 Jan 2015
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Autocrine Boost of NMDAR Current in Hippocampal CA1 Pyramidal Neurons by a PMCA-Dependent, Perisynaptic, Extracellular pH Shift
Huei-Ying Chen, Mitchell Chesler
Journal of Neuroscience 21 January 2015, 35 (3) 873-877; DOI: 10.1523/JNEUROSCI.2293-14.2015

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Autocrine Boost of NMDAR Current in Hippocampal CA1 Pyramidal Neurons by a PMCA-Dependent, Perisynaptic, Extracellular pH Shift
Huei-Ying Chen, Mitchell Chesler
Journal of Neuroscience 21 January 2015, 35 (3) 873-877; DOI: 10.1523/JNEUROSCI.2293-14.2015
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Keywords

  • benzolamide
  • CA1
  • Ca2+ ATPase
  • carbonic anhydrase
  • carboxyeosin
  • hippocampus

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