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Brief Communications

The Spinal Muscular Atrophy with Pontocerebellar Hypoplasia Gene VRK1 Regulates Neuronal Migration through an Amyloid-β Precursor Protein-Dependent Mechanism

Hadar Vinograd-Byk, Tamar Sapir, Lara Cantarero, Pedro A. Lazo, Sharon Zeligson, Dorit Lev, Tally Lerman-Sagie, Paul Renbaum, Orly Reiner and Ephrat Levy-Lahad
Journal of Neuroscience 21 January 2015, 35 (3) 936-942; https://doi.org/10.1523/JNEUROSCI.1998-14.2015
Hadar Vinograd-Byk
1Medical Genetics Institute, Shaare Zedek Medical Center, Jerusalem 91031, Israel,
2Hebrew University Medical School, Jerusalem 91120, Israel,
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Tamar Sapir
3Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel,
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Lara Cantarero
4Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas, Universidad de Salamanca, 37007 Salamanca, Spain,
5Instituto de Investigación Biomédica de Salamanca, Hospital Universitario de Salamanca, 37007 Salamanca, Spain, and
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Pedro A. Lazo
4Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas, Universidad de Salamanca, 37007 Salamanca, Spain,
5Instituto de Investigación Biomédica de Salamanca, Hospital Universitario de Salamanca, 37007 Salamanca, Spain, and
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  • ORCID record for Pedro A. Lazo
Sharon Zeligson
1Medical Genetics Institute, Shaare Zedek Medical Center, Jerusalem 91031, Israel,
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Dorit Lev
6Medical Genetics Institute,
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Tally Lerman-Sagie
7Pediatric Neurology Unit, Wolfson Medical Center, Holon 58100, Israel
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Paul Renbaum
1Medical Genetics Institute, Shaare Zedek Medical Center, Jerusalem 91031, Israel,
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Orly Reiner
3Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel,
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Ephrat Levy-Lahad
1Medical Genetics Institute, Shaare Zedek Medical Center, Jerusalem 91031, Israel,
2Hebrew University Medical School, Jerusalem 91120, Israel,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1998-14.2015
PubMed 
25609612
Published By 
Society for Neuroscience
History 
  • Received May 12, 2014
  • Revision received November 16, 2014
  • Accepted November 19, 2014
  • First published January 21, 2015.
  • Version of record published January 21, 2015.
Copyright & Usage 
Copyright © 2015 the authors 0270-6474/15/350936-08$15.00/0

Author Information

  1. Hadar Vinograd-Byk1,2,*,
  2. Tamar Sapir3,*,
  3. Lara Cantarero4,5,
  4. Pedro A. Lazo4,5,
  5. Sharon Zeligson1,
  6. Dorit Lev6,
  7. Tally Lerman-Sagie7,
  8. Paul Renbaum1,#,
  9. Orly Reiner3,#, and
  10. Ephrat Levy-Lahad1,2,#
  1. 1Medical Genetics Institute, Shaare Zedek Medical Center, Jerusalem 91031, Israel,
  2. 2Hebrew University Medical School, Jerusalem 91120, Israel,
  3. 3Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel,
  4. 4Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas, Universidad de Salamanca, 37007 Salamanca, Spain,
  5. 5Instituto de Investigación Biomédica de Salamanca, Hospital Universitario de Salamanca, 37007 Salamanca, Spain, and
  6. 6Medical Genetics Institute,
  7. 7Pediatric Neurology Unit, Wolfson Medical Center, Holon 58100, Israel
View Full Text

Author contributions

  1. Author contributions: H.V.-B., T.S., P.A.L., P.R., O.R., and E.L.-L. designed research; H.V.-B., T.S., L.C., S.Z., D.L., and T.L.-S. performed research; P.A.L. contributed unpublished reagents/analytic tools; H.V.-B., T.S., L.C., P.A.L., S.Z., P.R., O.R., and E.L.-L. analyzed data; H.V.-B., P.R., and E.L.-L. wrote the paper.

  2. ↵*H.V.-B. and T.S. contributed equally to this work.

  3. ↵#P.R., O.R., and E.L.-L. contributed equally to this work.

Disclosures

    • Received May 12, 2014.
    • Revision received November 16, 2014.
    • Accepted November 19, 2014.
  • This study was supported by grants from the Israel Science Foundation (Grant 702/13 to P.R. and E.L.-L., and Grant 47/10 and 322/13 to O.R. and T.S.); by the Minerva Foundation with funding from the Federal German Ministry for Education and Research, the Jérôme Lejeune Foundation, the Benoziyo Center for Neurological diseases, the Kekst Family Center for Medical Genetics, and the David and Fela Shapell Family Center for Genetic Disorders Research (to O.R.); by the JAE (Programa Junta para la Amplición de Estudios) Consejo Superior de Investigaciones Científicas Fondo Social Europeo fellowship (to L.C.); by the Ministerio de Educación, Ciencia e Innovación (SAF2010-14935 and SAF2013-44810R, to P.A.L.); and by Kutxa-Fundación Inbiomed (to P.A.L.). We thank Vennasa Zamor for technical assistance.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to either of the following: Ephrat Levy-Lahad, MD, Medical Genetics Institute, Shaare Zedek Medical Center, P.O. Box 3235, Jerusalem 91031, Israel. lahad{at}szmc.org.il; or Orly Reiner, PhD, Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel. orly.reiner{at}weizmann.ac.il

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The Journal of Neuroscience: 35 (3)
Journal of Neuroscience
Vol. 35, Issue 3
21 Jan 2015
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The Spinal Muscular Atrophy with Pontocerebellar Hypoplasia Gene VRK1 Regulates Neuronal Migration through an Amyloid-β Precursor Protein-Dependent Mechanism
Hadar Vinograd-Byk, Tamar Sapir, Lara Cantarero, Pedro A. Lazo, Sharon Zeligson, Dorit Lev, Tally Lerman-Sagie, Paul Renbaum, Orly Reiner, Ephrat Levy-Lahad
Journal of Neuroscience 21 January 2015, 35 (3) 936-942; DOI: 10.1523/JNEUROSCI.1998-14.2015

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The Spinal Muscular Atrophy with Pontocerebellar Hypoplasia Gene VRK1 Regulates Neuronal Migration through an Amyloid-β Precursor Protein-Dependent Mechanism
Hadar Vinograd-Byk, Tamar Sapir, Lara Cantarero, Pedro A. Lazo, Sharon Zeligson, Dorit Lev, Tally Lerman-Sagie, Paul Renbaum, Orly Reiner, Ephrat Levy-Lahad
Journal of Neuroscience 21 January 2015, 35 (3) 936-942; DOI: 10.1523/JNEUROSCI.1998-14.2015
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Keywords

  • APP
  • neuronal migration
  • SMA-PCH (spinal muscular atrophy pontocerebellar hypoplasia)
  • VRK1

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