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Articles, Neurobiology of Disease

The Effect of Body Posture on Brain Glymphatic Transport

Hedok Lee, Lulu Xie, Mei Yu, Hongyi Kang, Tian Feng, Rashid Deane, Jean Logan, Maiken Nedergaard and Helene Benveniste
Journal of Neuroscience 5 August 2015, 35 (31) 11034-11044; DOI: https://doi.org/10.1523/JNEUROSCI.1625-15.2015
Hedok Lee
1Department of Anesthesiology,
2Department of Radiology, and
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Lulu Xie
5Center for Translational Neuromedicine, University of Rochester, Rochester, New York 14627
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Mei Yu
1Department of Anesthesiology,
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Hongyi Kang
5Center for Translational Neuromedicine, University of Rochester, Rochester, New York 14627
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Tian Feng
3Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York 11794,
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Rashid Deane
5Center for Translational Neuromedicine, University of Rochester, Rochester, New York 14627
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Jean Logan
4Department of Radiology, New York University Langone Medical Center, New York, New York 10016, and
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Maiken Nedergaard
5Center for Translational Neuromedicine, University of Rochester, Rochester, New York 14627
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Helene Benveniste
1Department of Anesthesiology,
2Department of Radiology, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1625-15.2015
PubMed 
26245965
Published By 
Society for Neuroscience
History 
  • Received April 27, 2015
  • Revision received June 4, 2015
  • Accepted June 29, 2015
  • First published August 5, 2015.
  • Version of record published August 5, 2015.
Copyright & Usage 
Copyright © 2015 the authors 0270-6474/15/3511034-11$15.00/0

Author Information

  1. Hedok Lee1,2,*,
  2. Lulu Xie5,*,
  3. Mei Yu1,
  4. Hongyi Kang5,
  5. Tian Feng3,
  6. Rashid Deane5,
  7. Jean Logan4,
  8. Maiken Nedergaard5, and
  9. Helene Benveniste1,2
  1. 1Department of Anesthesiology,
  2. 2Department of Radiology, and
  3. 3Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York 11794,
  4. 4Department of Radiology, New York University Langone Medical Center, New York, New York 10016, and
  5. 5Center for Translational Neuromedicine, University of Rochester, Rochester, New York 14627
View Full Text

Author contributions

  1. Author contributions: H.L., L.X., M.N., and H.B. designed research; H.L., L.X., M.Y., H.K., R.D., M.N., and H.B. performed research; H.L., L.X., M.Y., R.D., J.L., and H.B. contributed unpublished reagents/analytic tools; H.L., L.X., H.K., T.F., R.D., J.L., and H.B. analyzed data; H.L., M.N., and H.B. wrote the paper.

  2. ↵*H.L. and L.X. contributed equally to this work.

View Abstract

Disclosures

    • Received April 27, 2015.
    • Revision received June 4, 2015.
    • Accepted June 29, 2015.
  • This work was supported by “FBRI” and the National Institutes of Health (Grant R01 AG048769 to H.B. and M.N.) and the Department of Anesthesiology, Stony Brook Medicine. We thank Gina DiCarlo from Department of Anesthesiology, Stony Brook Medicine, for editorial assistance.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Helene Benveniste, MD, PhD, Department of Anesthesiology, Stony Brook Medicine, Stony Brook, NY 11794. Helene.Benveniste{at}stonybrookmedicine.edu

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Article usage: August 2015 to June 2022

AbstractFullPdf
Aug 201516929975753
Sep 20153213129143
Oct 201513207199
Nov 20159049594
Dec 20159664957
Total 20152333213191146
Jan 201612463953
Feb 2016745108107
Mar 2016965304160
Apr 2016635187106
May 2016543160102
Jun 2016609158119
Jul 2016894152146
Aug 2016881311165
Sep 20161234253138
Oct 2016564301115
Nov 2016275584167
Dec 201622842275
Total 2016881929791453
Jan 2017328754116
Feb 2017244133698
Mar 20173241280122
Apr 2017282160481
May 201726163870
Jun 201725079140
Jul 2017288131882
Aug 201721053848
Sep 201719370255
Oct 201726182693
Nov 2017235106479
Dec 2017303115672
Total 2017317912007956
Jan 201825494742
Feb 2018364125067
Mar 201836660558
Apr 201827442487
May 201833351952
Jun 201829766754
Jul 201828963762
Aug 201826970267
Sep 201823957452
Oct 2018351648131
Nov 201832179557
Dec 201830551346
Total 201836628281775
Jan 201931947949
Feb 201929352785
Mar 201928688389
Apr 2019285126171
May 201923495371
Jun 201920886764
Jul 201930259873
Aug 201922071962
Sep 201922780378
Oct 2019302101673
Nov 2019448753110
Dec 201923469558
Total 201933589554883
Jan 20201622873169
Feb 202034662376
Mar 202021382993
Apr 2020296737259
May 2020234742494
Jun 2020209686116
Jul 202026868984
Aug 202033588694
Sep 20202721072103
Oct 202052181094
Nov 2020263782105
Dec 202041877855
Total 2020499795071742
Jan 2021266794114
Feb 2021325837119
Mar 202128096491
Apr 2021387832112
May 202133885889
Jun 202130982868
Jul 2021210112083
Aug 202129993571
Sep 202133097386
Oct 20212611069100
Nov 2021275153294
Dec 202128768072
Total 20213567114221099
Jan 202227760999
Feb 202238164380
Mar 202230358781
Apr 202225759482
May 2022308671123
Jun 2022319714133
Total 202218453818598
Total52759588878652
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The Journal of Neuroscience: 35 (31)
Journal of Neuroscience
Vol. 35, Issue 31
5 Aug 2015
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The Effect of Body Posture on Brain Glymphatic Transport
Hedok Lee, Lulu Xie, Mei Yu, Hongyi Kang, Tian Feng, Rashid Deane, Jean Logan, Maiken Nedergaard, Helene Benveniste
Journal of Neuroscience 5 August 2015, 35 (31) 11034-11044; DOI: 10.1523/JNEUROSCI.1625-15.2015

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The Effect of Body Posture on Brain Glymphatic Transport
Hedok Lee, Lulu Xie, Mei Yu, Hongyi Kang, Tian Feng, Rashid Deane, Jean Logan, Maiken Nedergaard, Helene Benveniste
Journal of Neuroscience 5 August 2015, 35 (31) 11034-11044; DOI: 10.1523/JNEUROSCI.1625-15.2015
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Keywords

  • brain
  • CSF
  • posture
  • sleep
  • unconsciousness
  • waste removal

Responses to this article

Respond to this article

Jump to comment:

  • Does side matter?
    Nour Noor
    Published on: 16 August 2015
  • Published on: (16 August 2015)
    Page navigation anchor for Does side matter?
    Does side matter?
    • Nour Noor, student

    Hello,

    I am very interested in this rather unique and enlightening study. I would really appreciate it if the following question was looked into:

    Is there any difference as to the effects of sleep on the human body while sleeping on the right side or left side in the lateral position?

    Conflict of Interest:

    None declared

    Competing Interests: None declared.

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