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Articles, Behavioral/Cognitive

Longitudinal Changes in Prefrontal Cortex Activation Underlie Declines in Adolescent Risk Taking

Yang Qu, Adriana Galvan, Andrew J. Fuligni, Matthew D. Lieberman and Eva H. Telzer
Journal of Neuroscience 12 August 2015, 35 (32) 11308-11314; DOI: https://doi.org/10.1523/JNEUROSCI.1553-15.2015
Yang Qu
1Department of Psychology,
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Adriana Galvan
3Department of Psychology,
4Brain Research Institute,
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Andrew J. Fuligni
3Department of Psychology,
5Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095
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Matthew D. Lieberman
3Department of Psychology,
5Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095
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Eva H. Telzer
1Department of Psychology,
2Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Illinois 61820, and
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Figures

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  • Figure 1.
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    Figure 1.

    Longitudinal change in behavioral performance on the BART is associated with longitudinal change in self-reported risk-taking behavior.

  • Figure 2.
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    Figure 2.

    A, Longitudinal declines in VLPFC activation during risk taking from T1 to T2. B, BOLD response in the VLPFC during risk taking (means and SEM) relative to the implicit baseline at T1 and T2.

  • Figure 3.
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    Figure 3.

    A, B, Longitudinal changes in (A) VLPFC and (B) VS during risk taking correlate with longitudinal changes in self-reported risk-taking behavior. The scatterplots are not independent analyses and are presented for illustration purposes.

  • Figure 4.
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    Figure 4.

    Longitudinal changes in neural coupling between VS and MPFC correlate with longitudinal changes in self-reported risk-taking behavior. The scatterplot is not an independent analysis and is presented for illustration purposes.

  • Figure 5.
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    Figure 5.

    Neural coupling between VS and MPFC at T1 correlate with risk-taking behavior at T1.

Tables

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    Table 1.

    Brain activity during risk-taking behavior

    Anatomical regionBrodmann's areasMontreal Neurological Institute coordinatestakb
    xyz
    Time 1
        Left VLPFC10−2759−85.58142
        Right VLPFC103056105.58278
        Left dorsolateral PFC9−3341287.09233
        Right dorsolateral PFC9/463338315.84357
        Left VS−98−28.6776
        Right VS1511−87.94110
        Left insula13/45−361118.36206
        Right insula13/45332048.31149
        ACC24/32−68286.99237
    Time 2
        Left VLPFC10−335943.3254
        Right VLPFC10396213.87158
        Left dorsolateral PFC9−4247285.83143
        Right dorsolateral PFC9/463350258.76270
        Left VS−158−28.0471
        Right VS158−27.14136
        Left insula13/45−332378.65252
        Right insula13/45332318.64203
        ACC24/32320227.43169
    • ↵at score at those coordinates (local maxima).

    • ↵bNumber of voxels in each significant cluster.

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The Journal of Neuroscience: 35 (32)
Journal of Neuroscience
Vol. 35, Issue 32
12 Aug 2015
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Longitudinal Changes in Prefrontal Cortex Activation Underlie Declines in Adolescent Risk Taking
Yang Qu, Adriana Galvan, Andrew J. Fuligni, Matthew D. Lieberman, Eva H. Telzer
Journal of Neuroscience 12 August 2015, 35 (32) 11308-11314; DOI: 10.1523/JNEUROSCI.1553-15.2015

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Longitudinal Changes in Prefrontal Cortex Activation Underlie Declines in Adolescent Risk Taking
Yang Qu, Adriana Galvan, Andrew J. Fuligni, Matthew D. Lieberman, Eva H. Telzer
Journal of Neuroscience 12 August 2015, 35 (32) 11308-11314; DOI: 10.1523/JNEUROSCI.1553-15.2015
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Keywords

  • adolescence
  • fMRI
  • prefrontal cortex
  • risk taking

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