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Articles, Cellular/Molecular

Inactivation of Protein Tyrosine Phosphatase Receptor Type Z by Pleiotrophin Promotes Remyelination through Activation of Differentiation of Oligodendrocyte Precursor Cells

Kazuya Kuboyama, Akihiro Fujikawa, Ryoko Suzuki and Masaharu Noda
Journal of Neuroscience 2 September 2015, 35 (35) 12162-12171; https://doi.org/10.1523/JNEUROSCI.2127-15.2015
Kazuya Kuboyama
1Division of Molecular Neurobiology, National Institute for Basic Biology, and
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Akihiro Fujikawa
1Division of Molecular Neurobiology, National Institute for Basic Biology, and
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Ryoko Suzuki
1Division of Molecular Neurobiology, National Institute for Basic Biology, and
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Masaharu Noda
1Division of Molecular Neurobiology, National Institute for Basic Biology, and
2School of Life Science, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, Aichi 444-8787, Japan
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2127-15.2015
PubMed 
26338327
Published By 
Society for Neuroscience
History 
  • Received June 1, 2015
  • Revision received July 6, 2015
  • Accepted July 23, 2015
  • First published September 2, 2015.
  • Version of record published September 2, 2015.
Copyright & Usage 
Copyright © 2015 the authors 0270-6474/15/3512163-10$15.00/0

Author Information

  1. Kazuya Kuboyama1,
  2. Akihiro Fujikawa1,
  3. Ryoko Suzuki1, and
  4. Masaharu Noda1,2
  1. 1Division of Molecular Neurobiology, National Institute for Basic Biology, and
  2. 2School of Life Science, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, Aichi 444-8787, Japan
View Full Text

Author contributions

  1. Author contributions: K.K., A.F., and M.N. designed research; K.K., A.F., and R.S. performed research; K.K., A.F., and M.N. analyzed data; K.K., A.F., and M.N. wrote the paper.

Disclosures

    • Received June 1, 2015.
    • Revision received July 6, 2015.
    • Accepted July 23, 2015.
  • This work was supported by Adaptable and Seamless Technology Transfer Program through Target-driven R&D (A-STEP), Japan Science and Technology Agency (M.N.); Imaging Science Project of the Center for Novel Science Initiatives; National Institutes of Natural Sciences (A.F.); and the Japan Society for the Promotion of Science (KAKENHI Grants 24700387 and 26830050 to K.K.). Micro-CT analyses were performed at the Model Animal Research Facility of the National Institute for Basic Biology (NIBB). Immunofluorescence photomicrograph images were acquired at the Spectrography and Bioimaging Facility, NIBB Core Research Facilities. We thank M. Katsuki for providing us with p53-deficient mice, Y. Isoshima and N. Nakanishi for technical assistance, and A. Kodama for secretarial assistance.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr. Masaharu Noda, Division of Molecular Neurobiology, National Institute for Basic Biology, 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi 444-8787, Japan. madon{at}nibb.ac.jp

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The Journal of Neuroscience: 35 (35)
Journal of Neuroscience
Vol. 35, Issue 35
2 Sep 2015
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Inactivation of Protein Tyrosine Phosphatase Receptor Type Z by Pleiotrophin Promotes Remyelination through Activation of Differentiation of Oligodendrocyte Precursor Cells
Kazuya Kuboyama, Akihiro Fujikawa, Ryoko Suzuki, Masaharu Noda
Journal of Neuroscience 2 September 2015, 35 (35) 12162-12171; DOI: 10.1523/JNEUROSCI.2127-15.2015

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Inactivation of Protein Tyrosine Phosphatase Receptor Type Z by Pleiotrophin Promotes Remyelination through Activation of Differentiation of Oligodendrocyte Precursor Cells
Kazuya Kuboyama, Akihiro Fujikawa, Ryoko Suzuki, Masaharu Noda
Journal of Neuroscience 2 September 2015, 35 (35) 12162-12171; DOI: 10.1523/JNEUROSCI.2127-15.2015
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Keywords

  • multiple sclerosis
  • oligodendrocyte
  • pleiotrophin
  • PTPRZ
  • remyelination
  • tyrosine phosphorylation

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